Any feedback?
Please rate this page
(sequences.php)
(0/150)

BRENDA support

Sequence of ENPP2_HUMAN

EC Number:3.1.4.39

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
alkylglycerophosphoethanolamine phosphodiesterase
Q13822
Homo sapiens
863
98994
Reaction
1-alkyl-sn-glycero-3-phosphoethanolamine + H2O = 1-alkyl-sn-glycerol 3-phosphate + ethanolamine
Other sequences found for EC No. 3.1.4.39

General information:

Sequence
show sequence in fasta format
  0 MARRSSFQSC QIISLFTFAV GVNICLGFTA HRIKRAEGWE EGPPTVLSDS PWTNISGSCK
 60 GRCFELQEAG PPDCRCDNLC KSYTSCCHDF DELCLKTARG WECTKDRCGE VRNEENACHC
120 SEDCLARGDC CTNYQVVCKG ESHWVDDDCE EIKAAECPAG FVRPPLIIFS VDGFRASYMK
180 KGSKVMPNIE KLRSCGTHSP YMRPVYPTKT FPNLYTLATG LYPESHGIVG NSMYDPVFDA
240 TFHLRGREKF NHRWWGGQPL WITATKQGVK AGTFFWSVVI PHERRILTIL QWLTLPDHER
300 PSVYAFYSEQ PDFSGHKYGP FGPEMTNPLR EIDKIVGQLM DGLKQLKLHR CVNVIFVGDH
360 GMEDVTCDRT EFLSNYLTNV DDITLVPGTL GRIRSKFSNN AKYDPKAIIA NLTCKKPDQH
420 FKPYLKQHLP KRLHYANNRR IEDIHLLVER RWHVARKPLD VYKKPSGKCF FQGDHGFDNK
480 VNSMQTVFVG YGSTFKYKTK VPPFENIELY NVMCDLLGLK PAPNNGTHGS LNHLLRTNTF
540 RPTMPEEVTR PNYPGIMYLQ SDFDLGCTCD DKVEPKNKLD ELNKRLHTKG STEERHLLYG
600 RPAVLYRTRY DILYHTDFES GYSEIFLMPL WTSYTVSKQA EVSSVPDHLT SCVRPDVRVS
660 PSFSQNCLAY KNDKQMSYGF LFPPYLSSSP EAKYDAFLVT NMVPMYPAFK RVWNYFQRVL
720 VKKYASERNG VNVISGPIFD YDYDGLHDTE DKIKQYVEGS SIPVPTHYYS IITSCLDFTQ
780 PADKCDGPLS VSSFILPHRP DNEESCNSSE DESKWVEELM KMHTARVRDI EHLTSLDFFR
840 KTSRSYPEIL TLKTYLHTYE SEI
Download this sequence
in fasta format
Download all sequences for 3.1.4.39
in fasta format
in csv (Excel, OpenOffice) format
Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
414300
Murata J.,Lee H.Y.,Clair T.,Krutzsch H.C.,Arestad A.A.,Sobel M.E.,Liotta L.A.,Stracke M.L.
cDNA cloning of the human tumor motility-stimulating protein, autotaxin, reveals a homology with phosphodiesterases.
J. Biol. Chem.
269
30479-30484
1994
414301
Kawagoe H.,Soma O.,Goji J.,Nishimura N.,Narita M.,Inazawa J.,Nakamura H.,Sano K.
Molecular cloning and chromosomal assignment of the human brain-type phosphodiesterase I/nucleotide pyrophosphatase gene (PDNP2).
Genomics
30
380-384
1995
414302
Lee H.Y.,Murata J.,Clair T.,Polymeropoulos M.H.,Torres R.,Manrow R.E.,Liotta L.A.,Stracke M.L.
Cloning, chromosomal localization, and tissue expression of autotaxin from human teratocarcinoma cells.
Biochem. Biophys. Res. Commun.
218
714-719
1996
414303
van Meeteren L.A.,Ruurs P.,Christodoulou E.,Goding J.W.,Takakusa H.,Kikuchi K.,Perrakis A.,Nagano T.,Moolenaar W.H.
Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate.
J. Biol. Chem.
280
21155-21161
2005
414304
Giganti A.,Rodriguez M.,Fould B.,Moulharat N.,Coge F.,Chomarat P.,Galizzi J.-P.,Valet P.,Saulnier-Blache J.-S.,Boutin J.A.,Ferry G.
Murine and human autotaxin alpha, beta, and gamma isoforms: gene organization, tissue distribution, and biochemical characterization.
J. Biol. Chem.
283
7776-7789
2008
414305
Nusbaum C.,Mikkelsen T.S.,Zody M.C.,Asakawa S.,Taudien S.,Garber M.,Kodira C.D.,Schueler M.G.,Shimizu A.,Whittaker C.A.,Chang J.L.,Cuomo C.A.,Dewar K.,FitzGerald M.G.,Yang X.,Allen N.R.,Anderson S.,Asakawa T.,Blechschmidt K.,Bloom T.,Borowsky M.L.,Butler J.,Cook A.,Corum B.,DeArellano K.,DeCaprio D.,Dooley K.T.,Dorris L. III,Engels R.,Gloeckner G.,Hafez N.,Hagopian D.S.,Hall J.L.,Ishikawa S.K.,Jaffe D.B.,Kamat A.,Kudoh J.,Lehmann R.,Lokitsang T.,Macdonald P.,Major J.E.,Matthews C.D.,Mauceli E.,Menzel U.,Mihalev A.H.,Minoshima S.,Murayama Y.,Naylor J.W.,Nicol R.,Nguyen C.,O'Leary S.B.,O'Neill K.,Parker S.C.J.,Polley A.,Raymond C.K.,Reichwald K.,Rodriguez J.,Sasaki T.,Schilhabel M.,Siddiqui R.,Smith C.L.,Sneddon T.P.,Talamas J.A.,Tenzin P.,Topham K.,Venkataraman V.,Wen G.,Yamazaki S.,Young S.K.,Zeng Q.,Zimmer A.R.,Rosenthal A.,Birren B.W.,Platzer M.,Shimizu N.,Lander E.S.
DNA sequence and analysis of human chromosome 8.
Nature
439
331-335
2006
414306
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
414307
Tokumura A.,Majima E.,Kariya Y.,Tominaga K.,Kogure K.,Yasuda K.,Fukuzawa K.
Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase.
J. Biol. Chem.
277
39436-39442
2002
414308
Stracke M.L.,Krutzsch H.C.,Unsworth E.J.,Aarestad A.,Cioce V.,Schiffmann E.,Liotta L.A.
Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein.
J. Biol. Chem.
267
2524-2529
1992
414309
Nam S.W.,Clair T.,Kim Y.S.,McMarlin A.,Schiffmann E.,Liotta L.A.,Stracke M.L.
Autotaxin (NPP-2), a metastasis-enhancing mitogen, is an angiogenic factor.
Cancer Res.
61
6938-6944
2001
414310
Aoki J.,Taira A.,Takanezawa Y.,Kishi Y.,Hama K.,Kishimoto T.,Mizuno K.,Saku K.,Taguchi R.,Arai H.
Serum lysophosphatidic acid is produced through diverse phospholipase pathways.
J. Biol. Chem.
277
48737-48744
2002
414311
Clair T.,Aoki J.,Koh E.,Bandle R.W.,Nam S.W.,Ptaszynska M.M.,Mills G.B.,Schiffmann E.,Liotta L.A.,Stracke M.L.
Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate.
Cancer Res.
63
5446-5453
2003
414312
Boucher J.,Quilliot D.,Pradere J.P.,Simon M.F.,Gres S.,Guigne C.,Prevot D.,Ferry G.,Boutin J.A.,Carpene C.,Valet P.,Saulnier-Blache J.S.
Potential involvement of adipocyte insulin resistance in obesity-associated up-regulation of adipocyte lysophospholipase D/autotaxin expression.
Diabetologia
48
569-577
2005
414313
Bolen A.L.,Naren A.P.,Yarlagadda S.,Beranova-Giorgianni S.,Chen L.,Norman D.,Baker D.L.,Rowland M.M.,Best M.D.,Sano T.,Tsukahara T.,Liliom K.,Igarashi Y.,Tigyi G.
The phospholipase A1 activity of lysophospholipase A-I links platelet activation to LPA production during blood coagulation.
J. Lipid Res.
52
958-970
2011
414314
Hausmann J.,Kamtekar S.,Christodoulou E.,Day J.E.,Wu T.,Fulkerson Z.,Albers H.M.,van Meeteren L.A.,Houben A.J.,van Zeijl L.,Jansen S.,Andries M.,Hall T.,Pegg L.E.,Benson T.E.,Kasiem M.,Harlos K.,Kooi C.W.,Smyth S.S.,Ovaa H.,Bollen M.,Morris A.J.,Moolenaar W.H.,Perrakis A.
Structural basis of substrate discrimination and integrin binding by autotaxin.
Nat. Struct. Mol. Biol.
18
198-204
2011
414315
Stein A.J.,Bain G.,Prodanovich P.,Santini A.M.,Darlington J.,Stelzer N.M.,Sidhu R.S.,Schaub J.,Goulet L.,Lonergan D.,Calderon I.,Evans J.F.,Hutchinson J.H.
Structural Basis for Inhibition of Human Autotaxin by Four Potent Compounds with Distinct Modes of Binding.
Mol. Pharmacol.
88
982-992
2015
414316
Desroy N.,Housseman C.,Bock X.,Joncour A.,Bienvenu N.,Cherel L.,Labeguere V.,Rondet E.,Peixoto C.,Grassot J.M.,Picolet O.,Annoot D.,Triballeau N.,Monjardet A.,Wakselman E.,Roncoroni V.,Le Tallec S.,Blanque R.,Cottereaux C.,Vandervoort N.,Christophe T.,Mollat P.,Lamers M.,Auberval M.,Hrvacic B.,Ralic J.,Oste L.,van der Aar E.,Brys R.,Heckmann B.
Discovery of 2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary Fibrosis.
J. Med. Chem.
60
3580-3590
2017
414317
Bain G.,Shannon K.E.,Huang F.,Darlington J.,Goulet L.,Prodanovich P.,Ma G.L.,Santini A.M.,Stein A.J.,Lonergan D.,King C.D.,Calderon I.,Lai A.,Hutchinson J.H.,Evans J.F.
Selective Inhibition of Autotaxin Is Efficacious in Mouse Models of Liver Fibrosis.
J. Pharmacol. Exp. Ther.
360
1-13
2017