Sequence of CARB_PECCC
EC Number:2.3.1.226
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
malonyl-CoA + (S)-1-pyrroline-5-carboxylate + H2O = CoA + (2S,5S)-5-carboxymethylproline + CO2
Other sequences found for EC No. 2.3.1.226
General information:
Sequence
0 MVFEENSDEV RVITLDHPNK HNPFSRTLET SVKDALARAN ADDSVRAVVV YGGAERSFSA
60 GGDFNEVKQL SRSEDIEEWI DRVIDLYQAV LNVNKPTIAA VDGYAIGMGF QFALMFDQRL
120 MASTANFVMP ELKHGIGCSV GAAILGFTHG FSTMQEIIYQ CQSLDAPRCV DYRLVNQVVE
180 SSALLDAAIT QAHVMASYPA SAFINTKRAV NKPFIHLLEQ TRDASKAVHK AAFQARDAQG
240 HFKNVLGKKY
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in csv (Excel, OpenOffice) formatSequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
398117
McGowan S.J.,Sebaihia M.,O'Leary S.,Hardie K.R.,Williams P.,Stewart G.S.,Bycroft B.W.,Salmond G.P.
Analysis of the carbapenem gene cluster of Erwinia carotovora: definition of the antibiotic biosynthetic genes and evidence for a novel beta-lactam resistance mechanism.
Mol. Microbiol.
26
545-556
1997
398118
Gerratana B.,Arnett S.O.,Stapon A.,Townsend C.A.
Carboxymethylproline synthase from Pectobacterium carotorova: a multifaceted member of the crotonase superfamily.
Biochemistry
43
15936-15945
2004
398119
Sorensen J.L.,Sleeman M.C.,Schofield C.J.
Synthesis of deuterium labelled L- and D-glutamate semialdehydes and their evaluation as substrates for carboxymethylproline synthase (CarB)--implications for carbapenem biosynthesis.
Chem. Commun. (Camb.)
9
1155-1157
2005
398120
Sleeman M.C.,Schofield C.J.
Carboxymethylproline synthase (CarB), an unusual carbon-carbon bond-forming enzyme of the crotonase superfamily involved in carbapenem biosynthesis.
J. Biol. Chem.
279
6730-6736
2004
398121
Batchelar E.T.,Hamed R.B.,Ducho C.,Claridge T.D.,Edelmann M.J.,Kessler B.,Schofield C.J.
Thioester hydrolysis and C-C bond formation by carboxymethylproline synthase from the crotonase superfamily.
Angew. Chem. Int. Ed. Engl.
47
9322-9325
2008
398122
Hamed R.B.,Gomez-Castellanos J.R.,Thalhammer A.,Harding D.,Ducho C.,Claridge T.D.,Schofield C.J.
Stereoselective C-C bond formation catalysed by engineered carboxymethylproline synthases.
Nat. Chem.
3
365-371
2011
398123
Sleeman M.C.,Sorensen J.L.,Batchelar E.T.,McDonough M.A.,Schofield C.J.
Structural and mechanistic studies on carboxymethylproline synthase (CarB), a unique member of the crotonase superfamily catalyzing the first step in carbapenem biosynthesis.
J. Biol. Chem.
280
34956-34965
2005
