Sequence of BIRA_MYCTU
EC Number:6.3.4.15
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
biotin-[biotin carboxyl-carrier protein] ligase
I6YFP0
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
266
28121
Reaction
ATP + biotin + [biotin carboxyl-carrier protein]-L-lysine = AMP + diphosphate + [biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine
Other sequences found for EC No. 6.3.4.15
General information:
Sequence
0 MTDRDRLRPP LDERSLRDQL IGAGSGWRQL DVVAQTGSTN ADLLARAASG ADIDGVVLIA
60 EHQTAGRGRH GRGWAATARA QIILSVGVRV VDVPVQAWGW LSLAAGLAVL DSVAPLIAVP
120 PAETGLKWPN DVLARGGKLA GILAEVAQPF VVLGVGLNVT QAPEEVDPDA TSLLDLGVAA
180 PDRNRIASRL LRELEARIIQ WRNANPQLAA DYRARSLTIG SRVRVELPGG QDVVGIARDI
240 DDQGRLCLDV GGRTVVVSAG DVVHLR
Download this sequence
in fasta formatDownload all sequences for 6.3.4.15
in fasta format
in csv (Excel, OpenOffice) formatSequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
395435
Cole S.T.,Brosch R.,Parkhill J.,Garnier T.,Churcher C.M.,Harris D.E.,Gordon S.V.,Eiglmeier K.,Gas S.,Barry C.E. III,Tekaia F.,Badcock K.,Basham D.,Brown D.,Chillingworth T.,Connor R.,Davies R.M.,Devlin K.,Feltwell T.,Gentles S.,Hamlin N.,Holroyd S.,Hornsby T.,Jagels K.,Krogh A.,McLean J.,Moule S.,Murphy L.D.,Oliver S.,Osborne J.,Quail M.A.,Rajandream M.A.,Rogers J.,Rutter S.,Seeger K.,Skelton S.,Squares S.,Squares R.,Sulston J.E.,Taylor K.,Whitehead S.,Barrell B.G.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
Nature
393
537-544
1998
395436
Purushothaman S.,Gupta G.,Srivastava R.,Ramu V.G.,Surolia A.
Ligand specificity of group I biotin protein ligase of Mycobacterium tuberculosis.
PLoS ONE
3
0-0
2008
395437
Gupta V.,Gupta R.K.,Khare G.,Surolia A.,Salunke D.M.,Tyagi A.K.
Crystallization and preliminary X-ray diffraction analysis of biotin acetyl-CoA carboxylase ligase (BirA) from Mycobacterium tuberculosis.
Acta Crystallogr. F
64
524-527
2008
395438
Kelkar D.S.,Kumar D.,Kumar P.,Balakrishnan L.,Muthusamy B.,Yadav A.K.,Shrivastava P.,Marimuthu A.,Anand S.,Sundaram H.,Kingsbury R.,Harsha H.C.,Nair B.,Prasad T.S.,Chauhan D.S.,Katoch K.,Katoch V.M.,Kumar P.,Chaerkady R.,Ramachandran S.,Dash D.,Pandey A.
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
Mol. Cell. Proteomics
10
0-0
2011
395439
Bond T.E.H.,Sorenson A.E.,Schaeffer P.M.
A green fluorescent protein-based assay for high-throughput ligand-binding studies of a mycobacterial biotin protein ligase.
Microbiol. Res.
205
35-39
2017
395440
Gupta V.,Gupta R.K.,Khare G.,Salunke D.M.,Surolia A.,Tyagi A.K.
Structural ordering of disordered ligand-binding loops of biotin protein ligase into active conformations as a consequence of dehydration.
PLoS ONE
5
0-0
2010
395441
Duckworth B.P.,Geders T.W.,Tiwari D.,Boshoff H.I.,Sibbald P.A.,Barry C.E.,Schnappinger D.,Finzel B.C.,Aldrich C.C.
Bisubstrate adenylation inhibitors of biotin protein ligase from Mycobacterium tuberculosis.
Chem. Biol.
18
1432-1441
2011
395442
Ma Q.,Akhter Y.,Wilmanns M.,Ehebauer M.T.
Active site conformational changes upon reaction intermediate biotinyl-5'-AMP binding in biotin protein ligase from Mycobacterium tuberculosis.
Protein Sci.
23
932-939
2014
395443
Bockman M.R.,Kalinda A.S.,Petrelli R.,De la Mora-Rey T.,Tiwari D.,Liu F.,Dawadi S.,Nandakumar M.,Rhee K.Y.,Schnappinger D.,Finzel B.C.,Aldrich C.C.
Targeting Mycobacterium tuberculosis biotin protein ligase (MtBPL) with nucleoside-based bisubstrate adenylation inhibitors.
J. Med. Chem.
58
7349-7369
2015
