Sequence of VKOR1_RAT
EC Number:1.17.4.4
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
phylloquinol + a protein with a disulfide bond = phylloquinone + a protein with reduced L-cysteine residues
Other sequences found for EC No. 1.17.4.4
General information:
Sequence
0 MGTTWRSPGR LRLALCLAGL ALSLYALHVK AARARNEDYR ALCDVGTAIS CSRVFSSRWG
60 RGFGLVEHVL GADSILNQSN SIFGCMFYTI QLLLGCLRGR WASILLILSS LVSVAGSLYL
120 AWILFFVLYD FCIVCITTYA INAGLMLLSF QKVPEHKVKK P
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
375244
Rost S.,Fregin A.,Ivaskevicius V.,Conzelmann E.,Hoertnagel K.,Pelz H.-J.,Lappegard K.,Seifried E.,Scharrer I.,Tuddenham E.G.D.,Mueller C.R.,Strom T.M.,Oldenburg J.
Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2.
Nature
427
537-541
2004
375245
Li T.,Chang C.-Y.,Jin D.-Y.,Lin P.-J.,Khvorova A.,Stafford D.W.
Identification of the gene for vitamin K epoxide reductase.
Nature
427
541-544
2004
375246
Wajih N.,Sane D.C.,Hutson S.M.,Wallin R.
Engineering of a recombinant vitamin K-dependent (gamma)-carboxylation system with enhanced (gamma)-carboxyglutamic acid forming capacity: evidence for a functional CxxC redox center in the system.
J. Biol. Chem.
280
10540-10547
2005
375247
Matagrin B.,Hodroge A.,Montagut-Romans A.,Andru J.,Fourel I.,Besse S.,Benoit E.,Lattard V.
New insights into the catalytic mechanism of vitamin K epoxide reductase (VKORC1) - The catalytic properties of the major mutations of rVKORC1 explain the biological cost associated to mutations.
FEBS Open Bio
3
144-150
2013
375248
Hammed A.,Matagrin B.,Spohn G.,Prouillac C.,Benoit E.,Lattard V.
VKORC1L1, an enzyme rescuing the vitamin K 2,3-epoxide reductase activity in some extrahepatic tissues during anticoagulation therapy.
J. Biol. Chem.
288
28733-28742
2013
375249
Pelz H.J.,Rost S.,Hunerberg M.,Fregin A.,Heiberg A.C.,Baert K.,MacNicoll A.D.,Prescott C.V.,Walker A.S.,Oldenburg J.,Muller C.R.
The genetic basis of resistance to anticoagulants in rodents.
Genetics
170
1839-1847
2005
