Sequence of G0QSR3_ICHMG
EC Number:3.4.24.86
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-/-Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNFalpha). Similarly cleaves other membrane-anchored, cell-surface proteins to "shed" the extracellular domains
Other sequences found for EC No. 3.4.24.86
General information:
Sequence
0 MSNYLSYQKF FKNTINNTCQ PCHNSCMECF GSQYDKCISC DLGFFKLDQQ CLINVLLKNI
60 TKILQIINAY LVILPAFLQW SFRNNCTRCS ERQYLSNNTC INCTDGCNTC FSDICIQCNT
120 QLYNLNVSCV GSCPIDYYFP DQETFQCSQC YFKCKRCTGS SDKQCTACFQ NTYLYNGECL
180 STCNDITTYK NNDDNTCTKC HSSCLSCNGP LINNCTLCPQ SYYLHNSICI QACPSGFFSN
240 KNTFQCIACP SGCLQCTSYQ QCQKQTYQCL SCFHGCSKCF AQAQNECTSY QTDFICKKCP
300 ENCEQCTSLQ NCVLCKNAAF FLQNQTCLPC NYKCLTCTGP LDTQCTQSTC DQCDISCQTC
360 EQNPFKCTSC PLQNPFLLDN ECLNQCPLKD GYYQQGTQCL KCHFSCSQCI GPSQNQCTLC
420 PQNTFLSTTN QCVFNCPFGH FNDSKNNMCI ICDSQCLSCI DNPLNCTECP NNRPFLYQNT
480 CLLDCPDTFY KENTTKTCNK CSSLCLKCTE NPKKCTQCPN NLFFIPSLNA CESQCPPENY
540 YILNNTCLSC HISCKICNGP SQNECSSCCI NCDFSYLFFL SQCVSECPNQ KYYTEGSTCK
600 ECDISCLSCT GPLENQCLTC PQGRFFLNSQ CLLKCPLFNF YPDTKSNICV SCNKRCLTCV
660 EEKPLQCASQ NQCIFECPAE RFFQKNNQCI KCHFNCLKCT ESTEQNCTKC EQGMYLFQQQ
720 CLAGCPIKNF FEDKLNVQCI PCNSLCLSCR ANTPDECTQC YQGKYLLNKA CVENCPLKYF
780 IDLNEIICRP CSENCNICLQ LKNCQECIPP YRLLNGQCIN ECPQPGFYHI TKEKGQIECL
840 PCDSSCKTCN GSNQTQCTSC DNQSFLLLNK CVQKCNVGYF TNLEQRTCMQ CPEFCILCES
900 DIQNSTLKCT KCQTNYFLMN NLCSSSCSDG TYVSPTQALC LSCHSSCATC TGPFDYQCTQ
960 CPKAYYLYKN SCLTSCPEGY FISPLKKQTC EMCDQKCTLC FGANENNCLA CKNNFFFLNQ
1020 SCLLTCPSSY FKDQETLTCQ KCSQGCSKCE NNQNTACLSC EANYFYLNKQ CLINCPTKYF
1080 NDISTQQCLP CFTTCSSCTG TNRNQCFMCE KAYFLHQSQC ITSCPSGFYI NNMKQTCDQC
1140 SRKCFTCKNS SDFDCLSCSG ELFLFENTCR DQCPDRLFAN VQTQKCEQCS KGCLKCFNIE
1200 SFSCTECENG FFLYQGSCLD KCPDGQYIDQ IQKQCLPCDF SCLTCTGPQE NQCIFCKSNS
1260 LYRHPISQKC TLDCGKNFFP DISTGSCAPC DSSCKTCTSK HYNSCLSCQN NFFLINFQCV
1320 FQCPQDLVGD TQRQICIQKC PAGYFKNTLT NICDPCNNTC KTCSNIQTCE TCPNLQFLLN
1380 GKCLENCPEG FYTNQLTSIC IQCHFSCLNS CSGPNDFQCL NCQTGTFLYE GKCNKICPLG
1440 FFPDVLSSKC ANCNPTCLSC DGFSEKNCLS CSLQFYFLEN SCFRRCPPTF YEDIYQNKCL
1500 KCANGCRACF NSQSVSCTQC MNGFYLRNNE CNKECPNGFF TNKINLICET CHPSCLECNG
1560 PFYNSCLQCK EPNFLEQNTC QATCQAGYFP QISTKKCIKC NIECLTCFGG EKNECNQCKQ
1620 GSILETNQCS ACHQNCKKCT GPQLSDCQQC TQGFFLYCDS SCLNCSGPLP NQCLNCPPNR
1680 FFYDNLCVIT CLNSFFGDTQ KSKCISCNQD CKTCDGPLNN NCLSCNMFTY LLNNQCLLNC
1740 PLAYYKSDVF QQCIKCDPKC LTCNGRSPQS CLSCEYPLFL MYTECVYNCP QRRFGNPQNR
1800 KCDPCHPVCF NCFGQSNKQC TSCENGLYFF SYQCHLECPI GSYLNMIEDN CFSCHPSCES
1860 CTGPKQNQCR SCYIETYLNL ITNTCVQICP QSYFAQKETG KCSLCDSQCS QCTHSSKNCT
1920 QCSQNRINTP QCECPPLTVF DSQNPFCESC FYRCQRCSKI PYNCIECAPS RNQDPPQCSC
1980 TEGTFDNGQT SQCQLCDFKC LTCVQMKHLC LKCRGDRITN DCVCPKGKFD DQINSYCQDC
2040 SIQCQECERE NQNCKICRGN RINPPFCDCP IGFFEDYKSV NCPKCANQCL ECTLRSTNCT
2100 KCSTTTDRIG VPLCSCRDGL YDDGINPICK NCHFHCSTCE SEFYCSKCAG NRLGTDNGIC
2160 ICPQNSTDMS HLNTAFCATC QVAVLQSYLS DNLEQIIVDF GQEIFFQGVN ASSDTFSIEN
2220 CFYLLDISTI IKLGRDAPSC KLTKTEIIIE LQSMSNIQIG DDIILLTNKF LMFSSCNQNG
2280 GNTSQFFQQI ENKKLSAPQN YLIPIVKLIG PQENVSVCAE IVIKIASTQN TGKRPLEKIT
2340 WFLMNKSEIS NNQVLHFLEN IIQETNKQQR LYLQIPALNL DEFTVYIFKV SFQNYLGQEG
2400 YSIYQFKTSS TESPFIQIDQ DSPLTVITRN PINIVAKVAH LKCDAGKIIE IKDEMKVIWL
2460 QTTGKPQIIK QIEQIKSPEN IIIVQEIPHF TLLPEQIYNI QAIAQIVVNG NTLQSISTLQ
2520 IVALPSKLIS YIEGGNRISG FANTLIVQGY GKDPDIFNEE DSLKDLNYIW NCINLNTGEQ
2580 CNITLVNQKQ IIVPPKILLP YNAYEFKLTI TKGQRSESSK VTILISELDL PKLDLDIPLH
2640 LMNKKLNLDE EIKLDLKYKN ASPDNLYYAG VLIYDFNNVA TIRFDYLTFK FRIWNYFNKF
2700 TKSNTISFRA SLNSLTDFRT LQNFQSVLPP GKLEQFPSSL LDKDMPLDFD NIDKQNYIMI
2760 VFSIIDGLGG IRNITKVIHV NENKDFNEKN LLDIWDKQKG TIESEIFQMI KVKNMNPKNL
2820 LVILFLQHLK
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