Sequence of PRTN3_HUMAN

Myeloblastin

P24158

256

27807

338014

Labbaye C.,Musette P.,Cayre Y.E.

Wegener autoantigen and myeloblastin are encoded by a single mRNA.

Proc. Natl. Acad. Sci. U.S.A.

88

9253-9256

1991

338015

Grimwood J.,Gordon L.A.,Olsen A.S.,Terry A.,Schmutz J.,Lamerdin J.E.,Hellsten U.,Goodstein D.,Couronne O.,Tran-Gyamfi M.,Aerts A.,Altherr M.,Ashworth L.,Bajorek E.,Black S.,Branscomb E.,Caenepeel S.,Carrano A.V.,Caoile C.,Chan Y.M.,Christensen M.,Cleland C.A.,Copeland A.,Dalin E.,Dehal P.,Denys M.,Detter J.C.,Escobar J.,Flowers D.,Fotopulos D.,Garcia C.,Georgescu A.M.,Glavina T.,Gomez M.,Gonzales E.,Groza M.,Hammon N.,Hawkins T.,Haydu L.,Ho I.,Huang W.,Israni S.,Jett J.,Kadner K.,Kimball H.,Kobayashi A.,Larionov V.,Leem S.-H.,Lopez F.,Lou Y.,Lowry S.,Malfatti S.,Martinez D.,McCready P.M.,Medina C.,Morgan J.,Nelson K.,Nolan M.,Ovcharenko I.,Pitluck S.,Pollard M.,Popkie A.P.,Predki P.,Quan G.,Ramirez L.,Rash S.,Retterer J.,Rodriguez A.,Rogers S.,Salamov A.,Salazar A.,She X.,Smith D.,Slezak T.,Solovyev V.,Thayer N.,Tice H.,Tsai M.,Ustaszewska A.,Vo N.,Wagner M.,Wheeler J.,Wu K.,Xie G.,Yang J.,Dubchak I.,Furey T.S.,DeJong P.,Dickson M.,Gordon D.,Eichler E.E.,Pennacchio L.A.,Richardson P.,Stubbs L.,Rokhsar D.S.,Myers R.M.,Rubin E.M.,Lucas S.M.

The DNA sequence and biology of human chromosome 19.

Nature

428

529-535

2004

338017

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Genome Res.

14

2121-2127

2004

338018

Zimmer M.,Medcalf R.L.,Fink T.M.,Mattmann C.,Lichter P.,Jenne D.E.

Three human elastase-like genes coordinately expressed in the myelomonocyte lineage are organized as a single genetic locus on 19pter.

Proc. Natl. Acad. Sci. U.S.A.

89

8215-8219

1992

338019

Sturrock A.B.,Franklin K.F.,Rao G.,Marshall B.C.,Rebentisch M.B.,Lemons R.S.,Hoidal J.R.

Structure, chromosomal assignment, and expression of the gene for proteinase-3. The Wegener's granulomatosis autoantigen.

J. Biol. Chem.

267

21193-21199

1992

338020

Clave E.,Molldrem J.,Hensel N.,Raptis A.,Barrett A.J.

Donor-recipient polymorphism of the proteinase 3 gene: a potential target for T-cell alloresponses to myeloid leukemia.

J. Immunother.

22

1-6

1999

338021

Musette P.,Labbaye C.,Dorner M.H.,Cayre Y.E.,Casanova J.-L.,Kourilsky P.

Wegener's autoantigen and leukemia.

Blood

77

1398-1399

1991

338022

Campanelli D.,Melchior M.,Fu Y.,Nakata M.,Shuman H.,Nathan C.,Gabay J.E.

Cloning of cDNA for proteinase 3: a serine protease, antibiotic, and autoantigen from human neutrophils.

J. Exp. Med.

172

1709-1715

1990

338023

Bories D.,Raynal M.-C.,Solomon D.H.,Darzynkiewicz Z.,Cayre Y.E.

Down-regulation of a serine protease, myeloblastin, causes growth arrest and differentiation of promyelocytic leukemia cells.

Cell

59

959-968

1989

338024

Jenne D.E.,Tschopp J.,Luedemann J.,Utecht B.,Gross W.L.

Wegener's autoantigen decoded.

Nature

346

520-520

1990

338025

Rao N.V.,Wehner N.G.,Marshall B.C.,Gray W.R.,Gray B.H.,Hoidal J.R.

Characterization of proteinase-3 (PR-3), a neutrophil serine proteinase. Structural and functional properties.

J. Biol. Chem.

266

9540-9548

1991

338026

Wilde C.G.,Snable J.L.,Griffith J.E.,Scott R.W.

Characterization of two azurphil granule proteases with active-site homology to neutrophil elastase.

J. Biol. Chem.

265

2038-2041

1990

338027

Ohlsson K.,Linder C.,Rosengren M.

Monoclonal antibodies specific for neutrophil proteinase 4. Production and use for isolation of the enzyme.

Biol. Chem. Hoppe-Seyler

371

549-555

1990

338028

Goldschmeding R.,Dolman K.M.,van den Ende M.E.,van der Meer-Gerritsen C.H.,Sonnenberg A.,von dem Borne A.E.

The relation of 29 kD C-ANCA antigen to proteinase 3.

APMIS Suppl.

19

26-27

1990

338029

Niles J.L.,McCluskey R.T.,Ahmad M.F.,Arnaout M.A.

Wegener's granulomatosis autoantigen is a novel neutrophil serine proteinase.

Blood

74

1888-1893

1989

338030

Gabay J.E.,Scott R.W.,Campanelli D.,Griffith J.,Wilde C.,Marra M.N.,Seeger M.,Nathan C.F.

Antibiotic proteins of human polymorphonuclear leukocytes.

Proc. Natl. Acad. Sci. U.S.A.

86

5610-5614

1989

338031

Gaskin G.,Kendal H.,Coulthart A.,Turner N.,Pusey C.D.

Use of proteinase 3 purified by reverse phase HPLC to detect autoantibodies in systemic vasculitis.

J. Immunol. Methods

180

25-33

1995

338032

Ludemann J.,Utecht B.,Gross W.L.

Anti-neutrophil cytoplasm antibodies in Wegener's granulomatosis recognize an elastinolytic enzyme.

J. Exp. Med.

171

357-362

1990

338033

Duke-Cohan J.S.,Morimoto C.,Rocker J.A.,Schlossman S.F.

A novel form of dipeptidylpeptidase IV found in human serum. Isolation, characterization, and comparison with T lymphocyte membrane dipeptidylpeptidase IV (CD26).

J. Biol. Chem.

270

14107-14114

1995

338034

Kao R.C.,Wehner N.G.,Skubitz K.M.,Gray B.H.,Hoidal J.R.

Proteinase 3. A distinct human polymorphonuclear leukocyte proteinase that produces emphysema in hamsters.

J. Clin. Invest.

82

1963-1973

1988

338035

Gupta S.K.,Niles J.L.,McCluskey R.T.,Arnaout M.A.

Identity of Wegener's autoantigen (p29) with proteinase 3 and myeloblastin.

Blood

76

2162-2162

1990

338036

von Vietinghoff S.,Tunnemann G.,Eulenberg C.,Wellner M.,Cristina Cardoso M.,Luft F.C.,Kettritz R.

NB1 mediates surface expression of the ANCA antigen proteinase 3 on human neutrophils.

Blood

109

4487-4493

2007

338037

von Vietinghoff S.,Eulenberg C.,Wellner M.,Luft F.C.,Kettritz R.

Neutrophil surface presentation of the anti-neutrophil cytoplasmic antibody-antigen proteinase 3 depends on N-terminal processing.

Clin. Exp. Immunol.

152

508-516

2008

338038

Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.

Initial characterization of the human central proteome.

BMC Syst. Biol.

5

17-17

2011

338039

Jerke U.,Rolle S.,Dittmar G.,Bayat B.,Santoso S.,Sporbert A.,Luft F.,Kettritz R.

Complement receptor Mac-1 is an adaptor for NB1 (CD177)-mediated PR3-ANCA neutrophil activation.

J. Biol. Chem.

286

7070-7081

2011

338040

Kuckleburg C.J.,Tilkens S.B.,Santoso S.,Newman P.J.

Proteinase 3 contributes to transendothelial migration of NB1-positive neutrophils.

J. Immunol.

188

2419-2426

2012

338041

Kuckleburg C.J.,Newman P.J.

Neutrophil proteinase 3 acts on protease-activated receptor-2 to enhance vascular endothelial cell barrier function.

Arterioscler. Thromb. Vasc. Biol.

33

275-284

2013

338042

Vaca Jacome A.S.,Rabilloud T.,Schaeffer-Reiss C.,Rompais M.,Ayoub D.,Lane L.,Bairoch A.,Van Dorsselaer A.,Carapito C.

N-terminome analysis of the human mitochondrial proteome.

Proteomics

15

2519-2524

2015

338043

Jerke U.,Marino S.F.,Daumke O.,Kettritz R.

Characterization of the CD177 interaction with the ANCA antigen proteinase 3.

Sci. Rep.

7

43328-43328

2017

338044

Choi Y.J.,Kim S.,Choi Y.,Nielsen T.B.,Yan J.,Lu A.,Ruan J.,Lee H.R.,Wu H.,Spellberg B.,Jung J.U.

SERPINB1-mediated checkpoint of inflammatory caspase activation.

Nat. Immunol.

20

276-287

2019

338045

Fujinaga M.,Charnaia M.M.,Halenbeck R.,Koths K.,James M.N.G.

The crystal structure of PR3, a neutrophil serine proteinase antigen of Wegener's granulomatosis antibodies.

J. Mol. Biol.

261

267-278

1996