Sequence of FES_HUMAN
EC Number:2.7.10.2
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Other sequences found for EC No. 2.7.10.2
General information:
Sequence
0 MGFSSELCSP QGHGVLQQMQ EAELRLLEGM RKWMAQRVKS DREYAGLLHH MSLQDSGGQS
60 RAISPDSPIS QSWAEITSQT EGLSRLLRQH AEDLNSGPLS KLSLLIRERQ QLRKTYSEQW
120 QQLQQELTKT HSQDIEKLKS QYRALARDSA QAKRKYQEAS KDKDRDKAKD KYVRSLWKLF
180 AHHNRYVLGV RAAQLHHQHH HQLLLPGLLR SLQDLHEEMA CILKEILQEY LEISSLVQDE
240 VVAIHREMAA AAARIQPEAE YQGFLRQYGS APDVPPCVTF DESLLEEGEP LEPGELQLNE
300 LTVESVQHTL TSVTDELAVA TEMVFRRQEM VTQLQQELRN EEENTHPRER VQLLGKRQVL
360 QEALQGLQVA LCSQAKLQAQ QELLQTKLEH LGPGEPPPVL LLQDDRHSTS SSEQEREGGR
420 TPTLEILKSH ISGIFRPKFS LPPPLQLIPE VQKPLHEQLW YHGAIPRAEV AELLVHSGDF
480 LVRESQGKQE YVLSVLWDGL PRHFIIQSLD NLYRLEGEGF PSIPLLIDHL LSTQQPLTKK
540 SGVVLHRAVP KDKWVLNHED LVLGEQIGRG NFGEVFSGRL RADNTLVAVK SCRETLPPDL
600 KAKFLQEARI LKQYSHPNIV RLIGVCTQKQ PIYIVMELVQ GGDFLTFLRT EGARLRVKTL
660 LQMVGDAAAG MEYLESKCCI HRDLAARNCL VTEKNVLKIS DFGMSREEAD GVYAASGGLR
720 QVPVKWTAPE ALNYGRYSSE SDVWSFGILL WETFSLGASP YPNLSNQQTR EFVEKGGRLP
780 CPELCPDAVF RLMEQCWAYE PGQRPSFSTI YQELQSIRKR HR
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
33523
Alcalay M.,Antolini F.,van de Ven W.J.M.,Lanfrancone L.,Grignani F.,Pelicci P.G.
Characterization of human and mouse c-fes cDNA clones and identification of the 5' end of the gene.
Oncogene
5
267-275
1990
33524
Roebroek A.J.M.,Schalken J.A.,Verbeek J.S.,van den Ouweland A.M.W.,Onnekink C.,Bloemers H.P.J.,van de Ven W.J.M.
The structure of the human c-fes/fps proto-oncogene.
EMBO J.
4
2897-2903
1985
33526
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
33527
Zody M.C.,Garber M.,Sharpe T.,Young S.K.,Rowen L.,O'Neill K.,Whittaker C.A.,Kamal M.,Chang J.L.,Cuomo C.A.,Dewar K.,FitzGerald M.G.,Kodira C.D.,Madan A.,Qin S.,Yang X.,Abbasi N.,Abouelleil A.,Arachchi H.M.,Baradarani L.,Birditt B.,Bloom S.,Bloom T.,Borowsky M.L.,Burke J.,Butler J.,Cook A.,DeArellano K.,DeCaprio D.,Dorris L. III,Dors M.,Eichler E.E.,Engels R.,Fahey J.,Fleetwood P.,Friedman C.,Gearin G.,Hall J.L.,Hensley G.,Johnson E.,Jones C.,Kamat A.,Kaur A.,Locke D.P.,Madan A.,Munson G.,Jaffe D.B.,Lui A.,Macdonald P.,Mauceli E.,Naylor J.W.,Nesbitt R.,Nicol R.,O'Leary S.B.,Ratcliffe A.,Rounsley S.,She X.,Sneddon K.M.B.,Stewart S.,Sougnez C.,Stone S.M.,Topham K.,Vincent D.,Wang S.,Zimmer A.R.,Birren B.W.,Hood L.,Lander E.S.,Nusbaum C.
Analysis of the DNA sequence and duplication history of human chromosome 15.
Nature
440
671-675
2006
33529
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
33530
Yu G.,Smithgall T.E.,Glazer R.I.
K562 leukemia cells transfected with the human c-fes gene acquire the ability to undergo myeloid differentiation.
J. Biol. Chem.
264
10276-10281
1989
33531
Hjermstad S.J.,Peters K.L.,Briggs S.D.,Glazer R.I.,Smithgall T.E.
Regulation of the human c-fes protein tyrosine kinase (p93c-fes) by its src homology 2 domain and major autophosphorylation site (Tyr-713).
Oncogene
8
2283-2292
1993
33532
Li J.,Smithgall T.E.
Co-expression with BCR induces activation of the FES tyrosine kinase and phosphorylation of specific N-terminal BCR tyrosine residues.
J. Biol. Chem.
271
32930-32936
1996
33533
Zirngibl R.,Schulze D.,Mirski S.E.,Cole S.P.,Greer P.A.
Subcellular localization analysis of the closely related Fps/Fes and Fer protein-tyrosine kinases suggests a distinct role for Fps/Fes in vesicular trafficking.
Exp. Cell Res.
266
87-94
2001
33534
Cheng H.Y.,Schiavone A.P.,Smithgall T.E.
A point mutation in the N-terminal coiled-coil domain releases c-Fes tyrosine kinase activity and survival signaling in myeloid leukemia cells.
Mol. Cell. Biol.
21
6170-6180
2001
33535
Greer P.
Closing in on the biological functions of Fps/Fes and Fer.
Nat. Rev. Mol. Cell Biol.
3
278-289
2002
33536
Laurent C.E.,Smithgall T.E.
The c-Fes tyrosine kinase cooperates with the breakpoint cluster region protein (Bcr) to induce neurite extension in a Rac- and Cdc42-dependent manner.
Exp. Cell Res.
299
188-198
2004
33537
Laurent C.E.,Delfino F.J.,Cheng H.Y.,Smithgall T.E.
The human c-Fes tyrosine kinase binds tubulin and microtubules through separate domains and promotes microtubule assembly.
Mol. Cell. Biol.
24
9351-9358
2004
33538
Sangrar W.,Zirgnibl R.A.,Gao Y.,Muller W.J.,Jia Z.,Greer P.A.
An identity crisis for fps/fes: oncogene or tumor suppressor?
Cancer Res.
65
3518-3522
2005
33539
Carlson A.,Berkowitz J.M.,Browning D.,Slamon D.J.,Gasson J.C.,Yates K.E.
Expression of c-Fes protein isoforms correlates with differentiation in myeloid leukemias.
DNA Cell Biol.
24
311-316
2005
33540
Delfino F.J.,Shaffer J.M.,Smithgall T.E.
The KRAB-associated co-repressor KAP-1 is a coiled-coil binding partner, substrate and activator of the c-Fes protein tyrosine kinase.
Biochem. J.
399
141-150
2006
33541
Delfino F.J.,Stevenson H.,Smithgall T.E.
A growth-suppressive function for the c-fes protein-tyrosine kinase in colorectal cancer.
J. Biol. Chem.
281
8829-8835
2006
33542
Voisset E.,Lopez S.,Dubreuil P.,De Sepulveda P.
The tyrosine kinase FES is an essential effector of KITD816V proliferation signal.
Blood
110
2593-2599
2007
33543
Naba A.,Reverdy C.,Louvard D.,Arpin M.
Spatial recruitment and activation of the Fes kinase by ezrin promotes HGF-induced cell scattering.
EMBO J.
27
38-50
2008
33544
Shaffer J.M.,Hellwig S.,Smithgall T.E.
Bimolecular fluorescence complementation demonstrates that the c-Fes protein-tyrosine kinase forms constitutive oligomers in living cells.
Biochemistry
48
4780-4788
2009
33545
Shaffer J.M.,Smithgall T.E.
Promoter methylation blocks FES protein-tyrosine kinase gene expression in colorectal cancer.
Genes Chromosomes Cancer
48
272-284
2009
33546
Kanda S.,Miyata Y.,Kanetake H.,Smithgall T.E.
Downregulation of the c-Fes protein-tyrosine kinase inhibits the proliferation of human renal carcinoma cells.
Int. J. Oncol.
34
89-96
2009
33547
McPherson V.A.,Everingham S.,Karisch R.,Smith J.A.,Udell C.M.,Zheng J.,Jia Z.,Craig A.W.
Contributions of F-BAR and SH2 domains of Fes protein tyrosine kinase for coupling to the FcepsilonRI pathway in mast cells.
Mol. Cell. Biol.
29
389-401
2009
33548
Oppermann F.S.,Gnad F.,Olsen J.V.,Hornberger R.,Greff Z.,Keri G.,Mann M.,Daub H.
Large-scale proteomics analysis of the human kinome.
Mol. Cell. Proteomics
8
1751-1764
2009
33549
Voisset E.,Lopez S.,Chaix A.,Georges C.,Hanssens K.,Prebet T.,Dubreuil P.,De Sepulveda P.
FES kinases are required for oncogenic FLT3 signaling.
Leukemia
24
721-728
2010
33550
Hellwig S.,Smithgall T.E.
Structure and regulation of the c-Fes protein-tyrosine kinase.
Front. Biosci.
16
3146-3155
2011
33551
Miyata Y.,Watanabe S.I.,Matsuo T.,Hayashi T.,Sakai H.,Xuan J.W.,Greer P.A.,Kanda S.
Pathological significance and predictive value for biochemical recurrence of c-Fes expression in prostate cancer.
Prostate
72
201-208
2012
33552
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
33553
Olvedy M.,Tisserand J.C.,Luciani F.,Boeckx B.,Wouters J.,Lopez S.,Rambow F.,Aibar S.,Thienpont B.,Barra J.,Koehler C.,Radaelli E.,Tartare-Deckert S.,Aerts S.,Dubreuil P.,van den Oord J.J.,Lambrechts D.,De Sepulveda P.,Marine J.C.
Comparative oncogenomics identifies tyrosine kinase FES as a tumor suppressor in melanoma.
J. Clin. Invest.
127
2310-2325
2017
33554
Scott A.,Pantoja-Uceda D.,Koshiba S.,Inoue M.,Kigawa T.,Terada T.,Shirouzu M.,Tanaka A.,Sugano S.,Yokoyama S.,Guentert P.
Solution structure of the Src homology 2 domain from the human feline sarcoma oncogene Fes.
J. Biomol. NMR
31
357-361
2005
33555
Filippakopoulos P.,Kofler M.,Hantschel O.,Gish G.D.,Grebien F.,Salah E.,Neudecker P.,Kay L.E.,Turk B.E.,Superti-Furga G.,Pawson T.,Knapp S.
Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation.
Cell
134
793-803
2008
33556
Greenman C.,Stephens P.,Smith R.,Dalgliesh G.L.,Hunter C.,Bignell G.,Davies H.,Teague J.,Butler A.,Stevens C.,Edkins S.,O'Meara S.,Vastrik I.,Schmidt E.E.,Avis T.,Barthorpe S.,Bhamra G.,Buck G.,Choudhury B.,Clements J.,Cole J.,Dicks E.,Forbes S.,Gray K.,Halliday K.,Harrison R.,Hills K.,Hinton J.,Jenkinson A.,Jones D.,Menzies A.,Mironenko T.,Perry J.,Raine K.,Richardson D.,Shepherd R.,Small A.,Tofts C.,Varian J.,Webb T.,West S.,Widaa S.,Yates A.,Cahill D.P.,Louis D.N.,Goldstraw P.,Nicholson A.G.,Brasseur F.,Looijenga L.,Weber B.L.,Chiew Y.-E.,DeFazio A.,Greaves M.F.,Green A.R.,Campbell P.,Birney E.,Easton D.F.,Chenevix-Trench G.,Tan M.-H.,Khoo S.K.,Teh B.T.,Yuen S.T.,Leung S.Y.,Wooster R.,Futreal P.A.,Stratton M.R.
Patterns of somatic mutation in human cancer genomes.
Nature
446
153-158
2007
