Sequence of KLK8_HUMAN
EC Number:3.4.21.118
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys
Other sequences found for EC No. 3.4.21.118
General information:
Sequence
0 MGRPRPRAAK TWMFLLLLGG AWAGHSRAQE DKVLGGHECQ PHSQPWQAAL FQGQQLLCGG
60 VLVGGNWVLT AAHCKKPKYT VRLGDHSLQN KDGPEQEIPV VQSIPHPCYN SSDVEDHNHD
120 LMLLQLRDQA SLGSKVKPIS LADHCTQPGQ KCTVSGWGTV TSPRENFPDT LNCAEVKIFP
180 QKKCEDAYPG QITDGMVCAG SSKGADTCQG DSGGPLVCDG ALQGITSWGS DPCGRSDKPG
240 VYTNICRYLD WIKKIIGSKG
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
310853
Yoshida S.,Taniguchi M.,Hirata A.,Shiosaka S.
Sequence analysis and expression of human neuropsin cDNA and gene.
Gene
213
9-16
1998
310854
Underwood L.J.,Tanimoto H.,Wang Y.,Shigemasa K.,Parmley T.H.,O'Brien T.J.
Cloning of tumor-associated differentially expressed gene-14, a novel serine protease overexpressed by ovarian carcinoma.
Cancer Res.
59
4435-4439
1999
310855
Mitsui S.,Tsuruoka N.,Yamashiro K.,Nakazato H.,Yamaguchi N.
A novel form of human neuropsin, a brain-related serine protease, is generated by alternative splicing and is expressed preferentially in human adult brain.
Eur. J. Biochem.
260
627-634
1999
310856
Gan L.,Lee I.,Smith R.,Argonza-Barrett R.,Lei H.,McCuaig J.,Moss P.,Paeper B.,Wang K.
Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region.
Gene
257
119-130
2000
310857
Magklara A.,Scorilas A.,Katsaros D.,Massobrio M.,Yousef G.M.,Fracchioli S.,Danese S.,Diamandis E.P.
The human KLK8 (neuropsin/ovasin) gene: identification of two novel splice variants and its prognostic value in ovarian cancer.
Clin. Cancer Res.
7
806-811
2001
310860
Clark H.F.,Gurney A.L.,Abaya E.,Baker K.,Baldwin D.T.,Brush J.,Chen J.,Chow B.,Chui C.,Crowley C.,Currell B.,Deuel B.,Dowd P.,Eaton D.,Foster J.S.,Grimaldi C.,Gu Q.,Hass P.E.,Heldens S.,Huang A.,Kim H.S.,Klimowski L.,Jin Y.,Johnson S.,Lee J.,Lewis L.,Liao D.,Mark M.R.,Robbie E.,Sanchez C.,Schoenfeld J.,Seshagiri S.,Simmons L.,Singh J.,Smith V.,Stinson J.,Vagts A.,Vandlen R.L.,Watanabe C.,Wieand D.,Woods K.,Xie M.-H.,Yansura D.G.,Yi S.,Yu G.,Yuan J.,Zhang M.,Zhang Z.,Goddard A.D.,Wood W.I.,Godowski P.J.,Gray A.M.
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
Genome Res.
13
2265-2270
2003
310861
Grimwood J.,Gordon L.A.,Olsen A.S.,Terry A.,Schmutz J.,Lamerdin J.E.,Hellsten U.,Goodstein D.,Couronne O.,Tran-Gyamfi M.,Aerts A.,Altherr M.,Ashworth L.,Bajorek E.,Black S.,Branscomb E.,Caenepeel S.,Carrano A.V.,Caoile C.,Chan Y.M.,Christensen M.,Cleland C.A.,Copeland A.,Dalin E.,Dehal P.,Denys M.,Detter J.C.,Escobar J.,Flowers D.,Fotopulos D.,Garcia C.,Georgescu A.M.,Glavina T.,Gomez M.,Gonzales E.,Groza M.,Hammon N.,Hawkins T.,Haydu L.,Ho I.,Huang W.,Israni S.,Jett J.,Kadner K.,Kimball H.,Kobayashi A.,Larionov V.,Leem S.-H.,Lopez F.,Lou Y.,Lowry S.,Malfatti S.,Martinez D.,McCready P.M.,Medina C.,Morgan J.,Nelson K.,Nolan M.,Ovcharenko I.,Pitluck S.,Pollard M.,Popkie A.P.,Predki P.,Quan G.,Ramirez L.,Rash S.,Retterer J.,Rodriguez A.,Rogers S.,Salamov A.,Salazar A.,She X.,Smith D.,Slezak T.,Solovyev V.,Thayer N.,Tice H.,Tsai M.,Ustaszewska A.,Vo N.,Wagner M.,Wheeler J.,Wu K.,Xie G.,Yang J.,Dubchak I.,Furey T.S.,DeJong P.,Dickson M.,Gordon D.,Eichler E.E.,Pennacchio L.A.,Richardson P.,Stubbs L.,Rokhsar D.S.,Myers R.M.,Rubin E.M.,Lucas S.M.
The DNA sequence and biology of human chromosome 19.
Nature
428
529-535
2004
310863
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
310864
Li Y.,Qian Y.-P.,Yu X.-J.,Wang Y.-Q.,Dong D.-G.,Sun W.,Ma R.-M.,Su B.
Recent origin of a hominoid-specific splice form of neuropsin, a gene involved in learning and memory.
Mol. Biol. Evol.
21
2111-2115
2004
310865
Shimizu-Okabe C.,Yousef G.M.,Diamandis E.P.,Yoshida S.,Shiosaka S.,Fahnestock M.
Expression of the kallikrein gene family in normal and Alzheimer's disease brain.
NeuroReport
12
2747-2751
2001
310866
Kuwae K.,Matsumoto-Miyai K.,Yoshida S.,Sadayama T.,Yoshikawa K.,Hosokawa K.,Shiosaka S.
Epidermal expression of serine protease, neuropsin (KLK8) in normal and pathological skin samples.
Mol. Pathol.
55
235-241
2002
310867
Kishi T.,Grass L.,Soosaipillai A.,Scorilas A.,Harbeck N.,Schmalfeldt B.,Dorn J.,Mysliwiec M.,Schmitt M.,Diamandis E.P.
Human kallikrein 8, a novel biomarker for ovarian carcinoma.
Cancer Res.
63
2771-2774
2003
310868
Rajapakse S.,Ogiwara K.,Takano N.,Moriyama A.,Takahashi T.
Biochemical characterization of human kallikrein 8 and its possible involvement in the degradation of extracellular matrix proteins.
FEBS Lett.
579
6879-6884
2005
310869
Lu Z.-X.,Peng J.,Su B.
A human-specific mutation leads to the origin of a novel splice form of neuropsin (KLK8), a gene involved in learning and memory.
Hum. Mutat.
28
978-984
2007
310870
Scott F.L.,Sun J.,Whisstock J.C.,Kato K.,Bird P.I.
SerpinB6 is an inhibitor of kallikrein-8 in keratinocytes.
J. Biochem.
142
435-442
2007
310871
Brattsand M.,Stefansson K.,Hubiche T.,Nilsson S.K.,Egelrud T.
SPINK9: a selective, skin-specific Kazal-type serine protease inhibitor.
J. Invest. Dermatol.
129
1656-1665
2009
