Sequence of KIME_RAT
EC Number:2.7.1.36
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + (R)-mevalonate = ADP + (R)-5-phosphomevalonate
Other sequences found for EC No. 2.7.1.36
General information:
Sequence
0 MLSEVLLVSA PGKVILHGEH AVVHGKVALA VALNLRTFLV LRPQSNGKVS LNLPNVGIKQ
60 VWDVATLQLL DTGFLEQGDV PAPTLEQLEK LKKVAGLPRD CVGNEGLSLL AFLYLYLAIC
120 RKQRTLPSLD IMVWSELPPG AGLGSSAAYS VCVAAALLTA CEEVTNPLKD RGSIGSWPEE
180 DLKSINKWAY EGERVIHGNP SGVDNSVSTW GGALRYQQGK MSSLKRLPAL QILLTNTKVP
240 RSTKALVAGV RSRLIKFPEI MAPLLTSIDA ISLECERVLG EMAAAPVPEQ YLVLEELMDM
300 NQHHLNALGV GHASLDQLCQ VTAAHGLHSK LTGAGGGGCG ITLLKPGLER AKVEAAKQAL
360 TGCGFDCWET SIGAPGVSMH SATSIEDPVR QALGL
Download this sequence
in fasta formatDownload all sequences for 2.7.1.36
in fasta format
in csv (Excel, OpenOffice) formatSequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
310457
Tanaka R.D.,Lee L.Y.,Schafer B.L.,Kratunis V.J.,Mohler W.A.,Robinson G.W.,Mosley S.T.
Molecular cloning of mevalonate kinase and regulation of its mRNA levels in rat liver.
Proc. Natl. Acad. Sci. U.S.A.
87
2872-2876
1990
310458
Hogenboom S.,Tuyp J.J.,Espeel M.,Koster J.,Wanders R.J.,Waterham H.R.
Mevalonate kinase is a cytosolic enzyme in humans.
J. Cell Sci.
117
631-639
2004
310459
Stamellos K.D.,Shackelford J.E.,Tanaka R.D.,Krisans S.K.
Mevalonate kinase is localized in rat liver peroxisomes.
J. Biol. Chem.
267
5560-5568
1992
310460
Chu X.,Li D.
Expression, purification, and characterization of His20 mutants of rat mevalonate kinase.
Protein Expr. Purif.
32
75-82
2003
310461
Fu Z.,Wang M.,Potter D.,Miziorko H.M.,Kim J.-J.
The structure of a binary complex between a mammalian mevalonate kinase and ATP: insights into the reaction mechanism and human inherited disease.
J. Biol. Chem.
277
18134-18142
2002
310462
Fu Z.,Voynova N.E.,Herdendorf T.J.,Miziorko H.M.,Kim J.J.
Biochemical and structural basis for feedback inhibition of mevalonate kinase and isoprenoid metabolism.
Biochemistry
47
3715-3724
2008
