Sequence of ESA1_YEAST
EC Number:2.3.1.48
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
histone acetyltransferase
Q08649
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
445
52613
Reaction
acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine
Other sequences found for EC No. 2.3.1.48
General information:
Sequence
0 MSHDGKEEPG IAKKINSVDD IIIKCQCWVQ KNDEERLAEI LSINTRKAPP KFYVHYVNYN
60 KRLDEWITTD RINLDKEVLY PKLKATDEDN KKQKKKKATN TSETPQDSLQ DGVDGFSREN
120 TDVMDLDNLN VQGIKDENIS HEDEIKKLRT SGSMTQNPHE VARVRNLNRI IMGKYEIEPW
180 YFSPYPIELT DEDFIYIDDF TLQYFGSKKQ YERYRKKCTL RHPPGNEIYR DDYVSFFEID
240 GRKQRTWCRN LCLLSKLFLD HKTLYYDVDP FLFYCMTRRD ELGHHLVGYF SKEKESADGY
300 NVACILTLPQ YQRMGYGKLL IEFSYELSKK ENKVGSPEKP LSDLGLLSYR AYWSDTLITL
360 LVEHQKEITI DEISSMTSMT TTDILHTAKT LNILRYYKGQ HIIFLNEDIL DRYNRLKAKK
420 RRTIDPNRLI WKPPVFTASQ LRFAW
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
31223
Boyer J.,Michaux G.,Fairhead C.,Gaillon L.,Dujon B.
Sequence and analysis of a 26.9 kb fragment from chromosome XV of the yeast Saccharomyces cerevisiae.
Yeast
12
1575-1586
1996
31224
Dujon B.,Albermann K.,Aldea M.,Alexandraki D.,Ansorge W.,Arino J.,Benes V.,Bohn C.,Bolotin-Fukuhara M.,Bordonne R.,Boyer J.,Camasses A.,Casamayor A.,Casas C.,Cheret G.,Cziepluch C.,Daignan-Fornier B.,Dang V.-D.,de Haan M.,Delius H.,Durand P.,Fairhead C.,Feldmann H.,Gaillon L.,Galisson F.,Gamo F.-J.,Gancedo C.,Goffeau A.,Goulding S.E.,Grivell L.A.,Habbig B.,Hand N.J.,Hani J.,Hattenhorst U.,Hebling U.,Hernando Y.,Herrero E.,Heumann K.,Hiesel R.,Hilger F.,Hofmann B.,Hollenberg C.P.,Hughes B.,Jauniaux J.-C.,Kalogeropoulos A.,Katsoulou C.,Kordes E.,Lafuente M.J.,Landt O.,Louis E.J.,Maarse A.C.,Madania A.,Mannhaupt G.,Marck C.,Martin R.P.,Mewes H.-W.,Michaux G.,Paces V.,Parle-McDermott A.G.,Pearson B.M.,Perrin A.,Pettersson B.,Poch O.,Pohl T.M.,Poirey R.,Portetelle D.,Pujol A.,Purnelle B.,Ramezani Rad M.,Rechmann S.,Schwager C.,Schweizer M.,Sor F.,Sterky F.,Tarassov I.A.,Teodoru C.,Tettelin H.,Thierry A.,Tobiasch E.,Tzermia M.,Uhlen M.,Unseld M.,Valens M.,Vandenbol M.,Vetter I.,Vlcek C.,Voet M.,Volckaert G.,Voss H.,Wambutt R.,Wedler H.,Wiemann S.,Winsor B.,Wolfe K.H.,Zollner A.,Zumstein E.,Kleine K.
The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.
Nature
387
98-102
1997
31225
Engel S.R.,Dietrich F.S.,Fisk D.G.,Binkley G.,Balakrishnan R.,Costanzo M.C.,Dwight S.S.,Hitz B.C.,Karra K.,Nash R.S.,Weng S.,Wong E.D.,Lloyd P.,Skrzypek M.S.,Miyasato S.R.,Simison M.,Cherry J.M.
The reference genome sequence of Saccharomyces cerevisiae: Then and now.
G3 (Bethesda)
4
389-398
2014
31226
Smith E.R.,Eisen A.,Gu W.,Sattah M.,Pannuti A.,Zhou J.,Cook R.G.,Lucchesi J.C.,Allis C.D.
ESA1 is a histone acetyltransferase that is essential for growth in yeast.
Proc. Natl. Acad. Sci. U.S.A.
95
3561-3565
1998
31227
Allard S.,Utley R.T.,Savard J.,Clarke A.S.,Grant P.A.,Brandl C.J.,Pillus L.,Workman J.L.,Cote J.
NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esa1p and the ATM-related cofactor Tra1p.
EMBO J.
18
5108-5119
1999
31228
Ikeda K.,Steger D.J.,Eberharter A.,Workman J.L.
Activation domain-specific and general transcription stimulation by native histone acetyltransferase complexes.
Mol. Cell. Biol.
19
855-863
1999
31229
Clarke A.S.,Lowell J.E.,Jacobson S.J.,Pillus L.
Esa1p is an essential histone acetyltransferase required for cell cycle progression.
Mol. Cell. Biol.
19
2515-2526
1999
31230
Vignali M.,Steger D.J.,Neely K.E.,Workman J.L.
Distribution of acetylated histones resulting from Gal4-VP16 recruitment of SAGA and NuA4 complexes.
EMBO J.
19
2629-2640
2000
31231
Galarneau L.,Nourani A.,Boudreault A.A.,Zhang Y.,Heliot L.,Allard S.,Savard J.,Lane W.S.,Stillman D.J.,Cote J.
Multiple links between the NuA4 histone acetyltransferase complex and epigenetic control of transcription.
Mol. Cell
5
927-937
2000
31232
Vogelauer M.,Wu J.,Suka N.,Grunstein M.
Global histone acetylation and deacetylation in yeast.
Nature
408
495-498
2000
31233
Suka N.,Suka Y.,Carmen A.A.,Wu J.,Grunstein M.
Highly specific antibodies determine histone acetylation site usage in yeast heterochromatin and euchromatin.
Mol. Cell
8
473-479
2001
31234
Adachi N.,Kimura A.,Horikoshi M.
A conserved motif common to the histone acetyltransferase Esa1 and the histone deacetylase Rpd3.
J. Biol. Chem.
277
35688-35695
2002
31235
Bird A.W.,Yu D.Y.,Pray-Grant M.G.,Qiu Q.,Harmon K.E.,Megee P.C.,Grant P.A.,Smith M.M.,Christman M.F.
Acetylation of histone H4 by Esa1 is required for DNA double-strand break repair.
Nature
419
411-415
2002
31236
Suka N.,Luo K.,Grunstein M.
Sir2p and Sas2p opposingly regulate acetylation of yeast histone H4 lysine 16 and spreading of heterochromatin.
Nat. Genet.
32
378-383
2002
31237
Hazbun T.R.,Malmstroem L.,Anderson S.,Graczyk B.J.,Fox B.,Riffle M.,Sundin B.A.,Aranda J.D.,McDonald W.H.,Chiu C.-H.,Snydsman B.E.,Bradley P.,Muller E.G.D.,Fields S.,Baker D.,Yates J.R. III,Davis T.N.
Assigning function to yeast proteins by integration of technologies.
Mol. Cell
12
1353-1365
2003
31238
Ghaemmaghami S.,Huh W.-K.,Bower K.,Howson R.W.,Belle A.,Dephoure N.,O'Shea E.K.,Weissman J.S.
Global analysis of protein expression in yeast.
Nature
425
737-741
2003
31239
Nourani A.,Utley R.T.,Allard S.,Cote J.
Recruitment of the NuA4 complex poises the PHO5 promoter for chromatin remodeling and activation.
EMBO J.
23
2597-2607
2004
31240
Robert F.,Pokholok D.K.,Hannett N.M.,Rinaldi N.J.,Chandy M.,Rolfe A.,Workman J.L.,Gifford D.K.,Young R.A.
Global position and recruitment of HATs and HDACs in the yeast genome.
Mol. Cell
16
199-209
2004
31241
Kobor M.S.,Venkatasubrahmanyam S.,Meneghini M.D.,Gin J.W.,Jennings J.L.,Link A.J.,Madhani H.D.,Rine J.
A protein complex containing the conserved Swi2/Snf2-related ATPase Swr1p deposits histone variant H2A.Z into euchromatin.
PLoS Biol.
2
587-599
2004
31242
Krogan N.J.,Baetz K.,Keogh M.-C.,Datta N.,Sawa C.,Kwok T.C.Y.,Thompson N.J.,Davey M.G.,Pootoolal J.,Hughes T.R.,Emili A.,Buratowski S.,Hieter P.,Greenblatt J.F.
Regulation of chromosome stability by the histone H2A variant Htz1, the Swr1 chromatin remodeling complex, and the histone acetyltransferase NuA4.
Proc. Natl. Acad. Sci. U.S.A.
101
13513-13518
2004
31243
Morillon A.,Karabetsou N.,Nair A.,Mellor J.
Dynamic lysine methylation on histone H3 defines the regulatory phase of gene transcription.
Mol. Cell
18
723-734
2005
31244
Tamburini B.A.,Tyler J.K.
Localized histone acetylation and deacetylation triggered by the homologous recombination pathway of double-strand DNA repair.
Mol. Cell. Biol.
25
4903-4913
2005
31245
Selleck W.,Fortin I.,Sermwittayawong D.,Cote J.,Tan S.
The Saccharomyces cerevisiae Piccolo NuA4 histone acetyltransferase complex requires the Enhancer of Polycomb A domain and chromodomain to acetylate nucleosomes.
Mol. Cell. Biol.
25
5535-5542
2005
31246
Albuquerque C.P.,Smolka M.B.,Payne S.H.,Bafna V.,Eng J.,Zhou H.
A multidimensional chromatography technology for in-depth phosphoproteome analysis.
Mol. Cell. Proteomics
7
1389-1396
2008
31247
Millar C.B.,Xu F.,Zhang K.,Grunstein M.
Acetylation of H2AZ Lys 14 is associated with genome-wide gene activity in yeast.
Genes Dev.
20
711-722
2006
31248
Berndsen C.E.,Albaugh B.N.,Tan S.,Denu J.M.
Catalytic mechanism of a MYST family histone acetyltransferase.
Biochemistry
46
623-629
2007
31249
Decker P.V.,Yu D.Y.,Iizuka M.,Qiu Q.,Smith M.M.
Catalytic-site mutations in the MYST family histone Acetyltransferase Esa1.
Genetics
178
1209-1220
2008
31250
Ginsburg D.S.,Govind C.K.,Hinnebusch A.G.
NuA4 lysine acetyltransferase Esa1 is targeted to coding regions and stimulates transcription elongation with Gcn5.
Mol. Cell. Biol.
29
6473-6487
2009
31251
Yi C.,Ma M.,Ran L.,Zheng J.,Tong J.,Zhu J.,Ma C.,Sun Y.,Zhang S.,Feng W.,Zhu L.,Le Y.,Gong X.,Yan X.,Hong B.,Jiang F.J.,Xie Z.,Miao D.,Deng H.,Yu L.
Function and molecular mechanism of acetylation in autophagy regulation.
Science
336
474-477
2012
31252
Li T.Y.,Song L.,Sun Y.,Li J.,Yi C.,Lam S.M.,Xu D.,Zhou L.,Li X.,Yang Y.,Zhang C.S.,Xie C.,Huang X.,Shui G.,Lin S.Y.,Reue K.,Lin S.C.
Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate.
Nat. Commun.
9
1916-1916
2018
31253
Kollenstart L.,de Groot A.J.L.,Janssen G.M.C.,Cheng X.,Vreeken K.,Martino F.,Cote J.,van Veelen P.A.,van Attikum H.
Gcn5 and Esa1 function as histone crotonyltransferases to regulate crotonylation-dependent transcription.
J. Biol. Chem.
294
20122-20134
2019
31254
Yan Y.,Barlev N.A.,Haley R.H.,Berger S.L.,Marmorstein R.
Crystal structure of yeast Esa1 suggests a unified mechanism for catalysis and substrate binding by histone acetyltransferases.
Mol. Cell
6
1195-1205
2000
31255
Yan Y.,Harper S.,Speicher D.W.,Marmorstein R.
The catalytic mechanism of the ESA1 histone acetyltransferase involves a self-acetylated intermediate.
Nat. Struct. Biol.
9
862-869
2002
31256
Yuan H.,Rossetto D.,Mellert H.,Dang W.,Srinivasan M.,Johnson J.,Hodawadekar S.,Ding E.C.,Speicher K.,Abshiru N.,Perry R.,Wu J.,Yang C.,Zheng Y.G.,Speicher D.W.,Thibault P.,Verreault A.,Johnson F.B.,Berger S.L.,Sternglanz R.,McMahon S.B.,Cote J.,Marmorstein R.
MYST protein acetyltransferase activity requires active site lysine autoacetylation.
EMBO J.
31
58-70
2012
