Sequence of GLCE_MOUSE
EC Number:5.1.3.17
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
heparosan-N-sulfate D-glucuronate = heparosan-N-sulfate L-iduronate
Other sequences found for EC No. 5.1.3.17
General information:
Sequence
0 MRCLAARVNY KTLIIICALF TLVTVLLWNK CSSDKAIQFP RHLSSGFRVD GLEKRSAASE
60 SNHYANHIAK QQSEEAFPQE QQKAPPVVGG FNSNGGSKVL GLKYEEIDCL INDEHTIKGR
120 REGNEVFLPF TWVEKYFDVY GKVVQYDGYD RFEFSHSYSK VYAQRSPYHP DGVFMSFEGY
180 NVEVRDRVKC ISGVEGVPLS TQWGPQGYFY PIQIAQYGLS HYSKNLTEKP PHIEVYETAE
240 DRDRNIRPNE WTVPKGCFMA SVADKSRSTN VKQFIAPETS EGVSLQLGNT KDFIISFDLK
300 LLTNGSVSVV LETTEKNQLF TVHYVSNTQL IAFRDRDIYY GIGPRTSWST VTRDLVTDLR
360 KGVGLSNTKA VKPTKIMPKK VVRLIAKGKG FLDNITISTT AHMAAFFAAS DWLVRNQDEK
420 GGWPIMVTRK LGEGFKSLEP GWYSAMAQGQ AISTLVRAYL LTKDYVFLSS ALRATAPYKF
480 PSEQHGVKAV FMNKHDWYEE YPTTPSSFVL NGFMYSLIGL YDLKETAGET LGKEARSLYE
540 RGMESLKAML PLYDTGSGTI YDLRHFMLGI APNLARWDYH TTHINQLQLL STIDESPIFK
600 EFVKRWKSYL KGSRAKHN
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
296857
Li J.-P.,Gong F.,El Darwish K.,Jalkanen M.,Lindahl U.
Characterization of the D-glucuronyl C5-epimerase involved in the biosynthesis of heparin and heparan sulfate.
J. Biol. Chem.
276
20069-20077
2001
296858
Crawford B.E.,Olson S.K.,Esko J.D.,Pinhal M.A.S.
Cloning, Golgi localization, and enzyme activity of the full-length heparin/heparan sulfate-glucuronic acid C5-epimerase.
J. Biol. Chem.
276
21538-21543
2001
296860
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
296861
Pinhal M.A.S.,Smith B.,Olson S.,Aikawa J.,Kimata K.,Esko J.D.
Enzyme interactions in heparan sulfate biosynthesis: uronosyl 5-epimerase and 2-O-sulfotransferase interact in vivo.
Proc. Natl. Acad. Sci. U.S.A.
98
12984-12989
2001
296862
Li J.P.,Gong F.,Hagner-McWhirter A.,Forsberg E.,Abrink M.,Kisilevsky R.,Zhang X.,Lindahl U.
Targeted disruption of a murine glucuronyl C5-epimerase gene results in heparan sulfate lacking L-iduronic acid and in neonatal lethality.
J. Biol. Chem.
278
28363-28366
2003
296863
Feyerabend T.B.,Li J.P.,Lindahl U.,Rodewald H.R.
Heparan sulfate C5-epimerase is essential for heparin biosynthesis in mast cells.
Nat. Chem. Biol.
2
195-196
2006
296864
Reijmers R.M.,Vondenhoff M.F.,Roozendaal R.,Kuil A.,Li J.P.,Spaargaren M.,Pals S.T.,Mebius R.E.
Impaired lymphoid organ development in mice lacking the heparan sulfate modifying enzyme glucuronyl C5-epimerase.
J. Immunol.
184
3656-3664
2010
