Sequence of DPP4_RAT
EC Number:3.4.14.5
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
release of an N-terminal dipeptide, Xaa-Yaa-/-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline
Other sequences found for EC No. 3.4.14.5
General information:
Sequence
0 MKTPWKVLLG LLGVAALVTI ITVPVVLLNK DEAAADSRRT YTLADYLKNT FRVKSYSLRW
60 VSDSEYLYKQ ENNILLFNAE HGNSSIFLEN STFEIFGDSI SDYSVSPDRL FVLLEYNYVK
120 QWRHSYTASY SIYDLNKRQL ITEEKIPNNT QWITWSQEGH KLAYVWKNDI YVKIEPHLPS
180 HRITSTGKEN VIFNGINDWV YEEEIFGAYS ALWWSPNGTF LAYAQFNDTG VPLIEYSFYS
240 DESLQYPKTV WIPYPKAGAV NPTVKFFIVN TDSLSSTTTT IPMQITAPAS VTTGDHYLCD
300 VAWVSEDRIS LQWLRRIQNY SVMAICDYDK TTLVWNCPTT QEHIETSATG WCGRFRPAEP
360 HFTSDGSSFY KIVSDKDGYK HICQFQKDRK PEQVCTFITK GAWEVISIEA LTSDYLYYIS
420 NEYKEMPGGR NLYKIQLTDH TNKKCLSCDL NPERCQYYSV SLSKEAKYYQ LGCRGPGLPL
480 YTLHRSTDQK ELRVLEDNSA LDKMLQDVQM PSKKLDFIVL NETRFWYQMI LPPHFDKSKK
540 YPLLIDVYAG PCSQKADAAF RLNWATYLAS TENIIVASFD GRGSGYQGDK IMHAINKRLG
600 TLEVEDQIEA ARQFLKMGFV DSKRVAIWGW SYGGYVTSMV LGSGSGVFKC GIAVAPVSRW
660 EYYDSVYTER YMGLPTPEDN LDHYRNSTVM SRAENFKQVE YLLIHGTADD NVHFQQSAQI
720 SKALVDAGVD FQAMWYTDED HGIASSTAHQ HIYSHMSHFL QQCFSLR
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
286100
Ogata S.,Misumi Y.,Ikehara Y.
Primary structure of rat liver dipeptidyl peptidase IV deduced from its cDNA and identification of the NH2-terminal signal sequence as the membrane-anchoring domain.
J. Biol. Chem.
264
3596-3601
1989
286101
Hong W.,Doyle D.
cDNA cloning for a bile canaliculus domain-specific membrane glycoprotein of rat hepatocytes.
Proc. Natl. Acad. Sci. U.S.A.
84
7962-7966
1987
286102
Hong W.J.,Doyle D.
Membrane orientation of rat gp110 as studied by in vitro translation.
J. Biol. Chem.
263
16892-16898
1988
286103
McCaughan G.W.,Wickson J.E.,Creswick P.F.,Gorrell M.D.
Identification of the bile canalicular cell surface molecule GP110 as the ectopeptidase dipeptidyl peptidase IV: an analysis by tissue distribution, purification and N-terminal amino acid sequence.
Hepatology
11
534-544
1990
286104
Iwaki-Egawa S.,Watanabe Y.,Fujimoto Y.
N-terminal amino acid sequence of the 60-kDa protein of rat kidney dipeptidyl peptidase IV.
Biol. Chem. Hoppe-Seyler
374
973-975
1993
286105
Ogata S.,Misumi Y.,Tsuji E.,Takami N.,Oda K.,Ikehara Y.
Identification of the active site residues in dipeptidyl peptidase IV by affinity labeling and site-directed mutagenesis.
Biochemistry
31
2582-2587
1992
286106
Hong W.,Doyle D.
Molecular dissection of the NH2-terminal signal/anchor sequence of rat dipeptidyl peptidase IV.
J. Cell Biol.
111
323-328
1990
286107
Longenecker K.L.,Stewart K.D.,Madar D.J.,Jakob C.G.,Fry E.H.,Wilk S.,Lin C.W.,Ballaron S.J.,Stashko M.A.,Lubben T.H.,Yong H.,Pireh D.,Pei Z.,Basha F.,Wiedeman P.E.,von Geldern T.W.,Trevillyan J.M.,Stoll V.S.
Crystal structures of DPP-IV (CD26) from rat kidney exhibit flexible accommodation of peptidase-selective inhibitors.
Biochemistry
45
7474-7482
2006
