Sequence of C7A21_PAPSO
EC Number:1.14.19.68
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
(S)-tetrahydrocolumbamine + [reduced NADPH-hemoprotein reductase] + O2 = (S)-canadine + [oxidized NADPH-hemoprotein reductase] + 2 H2O
Other sequences found for EC No. 1.14.19.68
General information:
Sequence
0 MIMSNLWILT LISTILAVFA AVLIIFRRRI SASTTEWPVG PKTLPIIGNL HILGGTALHV
60 VLHKLAEVYG SVMTIWIGSW KPVIIVSDFD RAWEVLVNKS SDYSAREMPE ITKIGTANWR
120 TISSSDSGPF WATLRKGLQS VALSPQHLAS QTAHQERDII KLIKNLKDEA ALNSGMVKPL
180 DHLKKATVRL ISRLIYGQDF DDDKYVEDMH DVIEFLIRIS GYAQLAEVFY YAKYLPSHKR
240 AVTGAEEAKR RVIALVRPFL QSNPATNTYL HFLKSQLYPE EVIIFAIFEA YLLGVDSTSS
300 TTAWALAFLI REPSVQEKLY QELKNFTANN NRTMLKVEDV NKLPYLQAVV KETMRMKPIA
360 PLAIPHKACK DTSLMGKKVD KGTKVMVNIH ALHHTEKVWK EPYKFMPERF LQKHDKAMEQ
420 SLLPFSAGMR ICAGMELGKL QFSFSLANLV NAFKWSCVSD GVLPDMSDLL GFVLFMKTPL
480 EARIVPRL
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
271840
Desgagne-Penix I.,Farrow S.C.,Cram D.,Nowak J.,Facchini P.J.
Integration of deep transcript and targeted metabolite profiles for eight cultivars of opium poppy.
Plant Mol. Biol.
79
295-313
2012
271841
Winzer T.,Gazda V.,He Z.,Kaminski F.,Kern M.,Larson T.R.,Li Y.,Meade F.,Teodor R.,Vaistij F.E.,Walker C.,Bowser T.A.,Graham I.A.
A Papaver somniferum 10-gene cluster for synthesis of the anticancer alkaloid noscapine.
Science
336
1704-1708
2012
271842
Dang T.T.,Facchini P.J.
Cloning and characterization of canadine synthase involved in noscapine biosynthesis in opium poppy.
FEBS Lett.
588
198-204
2014
271843
Li Y.,Smolke C.D.
Engineering biosynthesis of the anticancer alkaloid noscapine in yeast.
Nat. Commun.
7
12137-12137
2016
271844
Li Y.,Li S.,Thodey K.,Trenchard I.,Cravens A.,Smolke C.D.
Complete biosynthesis of noscapine and halogenated alkaloids in yeast.
Proc. Natl. Acad. Sci. U.S.A.
115
0-0
2018
