Sequence of BIRA_ECOLI
EC Number:6.3.4.15
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
biotin-[biotin carboxyl-carrier protein] ligase
P06709
Escherichia coli (strain K12)
321
35312
Reaction
ATP + biotin + [biotin carboxyl-carrier protein]-L-lysine = AMP + diphosphate + [biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine
Other sequences found for EC No. 6.3.4.15
General information:
Sequence
0 MKDNTVPLKL IALLANGEFH SGEQLGETLG MSRAAINKHI QTLRDWGVDV FTVPGKGYSL
60 PEPIQLLNAK QILGQLDGGS VAVLPVIDST NQYLLDRIGE LKSGDACIAE YQQAGRGRRG
120 RKWFSPFGAN LYLSMFWRLE QGPAAAIGLS LVIGIVMAEV LRKLGADKVR VKWPNDLYLQ
180 DRKLAGILVE LTGKTGDAAQ IVIGAGINMA MRRVEESVVN QGWITLQEAG INLDRNTLAA
240 MLIRELRAAL ELFEQEGLAP YLSRWEKLDN FINRPVKLII GDKEIFGISR GIDKQGALLL
300 EQDGIIKPWM GGEISLRSAE K
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
270516
Howard P.K.,Shaw J.,Otsuka A.J.
Nucleotide sequence of the birA gene encoding the biotin operon repressor and biotin holoenzyme synthetase functions of Escherichia coli.
Gene
35
321-331
1985
270517
Buoncristiani M.R.,Howard P.K.,Otsuka A.J.
DNA-binding and enzymatic domains of the bifunctional biotin operon repressor (BirA) of Escherichia coli.
Gene
44
255-261
1986
270518
Blattner F.R.,Burland V.D.,Plunkett G. III,Sofia H.J.,Daniels D.L.
Analysis of the Escherichia coli genome. IV. DNA sequence of the region from 89.2 to 92.8 minutes.
Nucleic Acids Res.
21
5408-5417
1993
270519
Blattner F.R.,Plunkett G. III,Bloch C.A.,Perna N.T.,Burland V.,Riley M.,Collado-Vides J.,Glasner J.D.,Rode C.K.,Mayhew G.F.,Gregor J.,Davis N.W.,Kirkpatrick H.A.,Goeden M.A.,Rose D.J.,Mau B.,Shao Y.
The complete genome sequence of Escherichia coli K-12.
Science
277
1453-1462
1997
270520
Hayashi K.,Morooka N.,Yamamoto Y.,Fujita K.,Isono K.,Choi S.,Ohtsubo E.,Baba T.,Wanner B.L.,Mori H.,Horiuchi T.
Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.
Mol. Syst. Biol.
2
0-0
2006
270521
Pucci M.J.,Discotto L.F.,Dougherty T.J.
Cloning and identification of the Escherichia coli murB DNA sequence, which encodes UDP-N-acetylenolpyruvoylglucosamine reductase.
J. Bacteriol.
174
1690-1693
1992
270522
Song W.-J.,Jackowski S.
Cloning, sequencing, and expression of the pantothenate kinase (coaA) gene of Escherichia coli.
J. Bacteriol.
174
6411-6417
1992
270523
Eisenberg M.A.,Prakash O.,Hsiung S.C.
Purification and properties of the biotin repressor. A bifunctional protein.
J. Biol. Chem.
257
15167-15173
1982
270524
Cronan J.E. Jr.
The E. coli bio operon: transcriptional repression by an essential protein modification enzyme.
Cell
58
427-429
1989
270525
Xu Y.,Beckett D.
Kinetics of biotinyl-5'-adenylate synthesis catalyzed by the Escherichia coli repressor of biotin biosynthesis and the stability of the enzyme-product complex.
Biochemistry
33
7354-7360
1994
270526
Streaker E.D.,Beckett D.
Coupling of protein assembly and DNA binding: biotin repressor dimerization precedes biotin operator binding.
J. Mol. Biol.
325
937-948
2003
270527
Chakravartty V.,Cronan J.E.
The wing of a winged helix-turn-helix transcription factor organizes the active site of BirA, a bifunctional repressor/ligase.
J. Biol. Chem.
288
36029-36039
2013
270528
Adikaram P.R.,Beckett D.
Protein:protein interactions in control of a transcriptional switch.
J. Mol. Biol.
425
4584-4594
2013
270529
Wilson K.P.,Shewchuk L.M.,Brennan R.G.,Otsuka A.J.,Matthews B.W.
Escherichia coli biotin holoenzyme synthetase/bio repressor crystal structure delineates the biotin- and DNA-binding domains.
Proc. Natl. Acad. Sci. U.S.A.
89
9257-9261
1992
270530
Weaver L.H.,Kwon K.,Beckett D.,Matthews B.W.
Corepressor-induced organization and assembly of the biotin repressor: a model for allosteric activation of a transcriptional regulator.
Proc. Natl. Acad. Sci. U.S.A.
98
6045-6050
2001
270531
Wood Z.A.,Weaver L.H.,Brown P.H.,Beckett D.,Matthews B.W.
Co-repressor induced order and biotin repressor dimerization: a case for divergent followed by convergent evolution.
J. Mol. Biol.
357
509-523
2006
