Sequence of ADCY8_RAT
EC Number:4.6.1.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP = 3',5'-cyclic AMP + diphosphate
Other sequences found for EC No. 4.6.1.1
General information:
Sequence
0 MELSDVHCLS GSEELYTIHP TPPAADGGSG SRPQRLLWQT AVRHITEQRF IHGHRGGGGG
60 GSRKASNPAG SGPNHHAPQL SSDSVLPLYS LGSGERAHNT GGTKVFPERS GSGSASGSGG
120 GGDLGFLHLD CAPSNSDFFL NGGYSYRGVI FPTLRNSFKS RDLERLYQRY FLGQRRKSEV
180 VMNVLDVLTK LTLLVLHLSL ASAPMDPLKG ILLGFFTGIE VVICALVVVR KDTTSHTYLQ
240 YSGVVTWVAM TTQILAAGLG YGLLGDGIGY VLFTLFATYS MLPLPLTWAI LAGLGTSLLQ
300 VTLQVLIPRL AVFSINQVLA QVVLFMCMNT AGIFISYLSD RAQRQAFLET RRCVEARLRL
360 ETENQRQERL VLSVLPRFVV LEMINDMTNV EDEHLQHQFH RIYIHRYENV SILFADVKGF
420 TNLSTTLSAQ ELVRMLNELF ARFDRLAHEH HCLRIKILGD CYYCVSGLPE PRQDHAHCCV
480 EMGLSMIKTI RFVRSRTKHD VDMRIGIHSG SVLCGVLGLR KWQFDVWSWD VDIANKLESG
540 GIPGRIHISK ATLDCLSGDY NVEEGHGKER NEFLRKHNIE TYLIKQPEES LLSLPEDIVK
600 ESVSCSDRRN SGATFTEGSW SPELPFDNIV GKQNTLAALT RNSINLLPNH LAQALHVQSG
660 PEEINKRIEH TIDLRSGDKL RREHIKPFSL MFKDSSLEHK YSQMRDEVFK SNLVCAFIVL
720 LFITAIQSLL PSSRLMPMTI QFSILIMLHS ALVLITTAED YKCLPLILRK TCCWINETYL
780 ARNVIIFASI LINFLGAVIN ILWCDFDKSI PLKNLTFNSS AVFTDICSYP EYFVFTGVLA
840 MVTCAVFLRL NSVLKLAVLL IMIAIYALLT ETIYAGLFLS YDNLNHSGED FLGTKEASLL
900 LMAMFLLAVF YHGQQLEYTA RLDFLWRVQA KEEINEMKDL REHNENMLRN ILPGHVARHF
960 LEKDRDNEEL YSQSYDAVGV MFASIPGFAD FYSQTEMNNQ GVECLRLLNE IIADFDELLG
1020 EDRFQDIEKI KTIGSTYMAV SGLSPEKQQC EDKWGHLCAL ADFSLALTES IQEINKHSFN
1080 NFELRIGISH GSVVAGVIGA KKPQYDIWGK TVNLASRMDS TGVSGRIQVP EETYLILKDQ
1140 GFAFDYRGEI YVKGISEQEG KIKTYFLLGR VQPNPFILPP RRLPGQYSLA AVVLGLVQSL
1200 NRQRQKQLLN ENSNSGIIKS HYNRRTLLTP SGPEPGAQAE GTDKSDLP
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
2508
Cali J.J.,Zwaagstra J.C.,Mons N.,Cooper D.M.,Krupinski J.
Type VIII adenylyl cyclase. A Ca2+/calmodulin-stimulated enzyme expressed in discrete regions of rat brain.
J. Biol. Chem.
269
12190-12195
1994
2509
Cali J.J.,Parekh R.S.,Krupinski J.
Splice variants of type VIII adenylyl cyclase. Differences in glycosylation and regulation by Ca2+/calmodulin.
J. Biol. Chem.
271
1089-1095
1996
2510
Gu C.,Cali J.J.,Cooper D.M.
Dimerization of mammalian adenylate cyclases.
Eur. J. Biochem.
269
413-421
2002
2511
Smith K.E.,Gu C.,Fagan K.A.,Hu B.,Cooper D.M.
Residence of adenylyl cyclase type 8 in caveolae is necessary but not sufficient for regulation by capacitative Ca(2+) entry.
J. Biol. Chem.
277
6025-6031
2002
2512
Delmeire D.,Flamez D.,Hinke S.A.,Cali J.J.,Pipeleers D.,Schuit F.
Type VIII adenylyl cyclase in rat beta cells: coincidence signal detector/generator for glucose and GLP-1.
Diabetologia
46
1383-1393
2003
2513
Steiner D.,Avidor-Reiss T.,Schallmach E.,Saya D.,Vogel Z.
Inhibition and superactivation of the calcium-stimulated isoforms of adenylyl cyclase: role of Gbetagamma dimers.
J. Mol. Neurosci.
27
195-203
2005
2514
Clement N.,Glorian M.,Raymondjean M.,Andreani M.,Limon I.
PGE2 amplifies the effects of IL-1beta on vascular smooth muscle cell de-differentiation: a consequence of the versatility of PGE2 receptors 3 due to the emerging expression of adenylyl cyclase 8.
J. Cell. Physiol.
208
495-505
2006
2515
Crossthwaite A.J.,Ciruela A.,Rayner T.F.,Cooper D.M.
A direct interaction between the N terminus of adenylyl cyclase AC8 and the catalytic subunit of protein phosphatase 2A.
Mol. Pharmacol.
69
608-617
2006
2516
Pagano M.,Clynes M.A.,Masada N.,Ciruela A.,Ayling L.J.,Wachten S.,Cooper D.M.
Insights into the residence in lipid rafts of adenylyl cyclase AC8 and its regulation by capacitative calcium entry.
Am. J. Physiol.
296
0-0
2009
2517
Macdougall D.A.,Wachten S.,Ciruela A.,Sinz A.,Cooper D.M.
Separate elements within a single IQ-like motif in adenylyl cyclase type 8 impart ca2+/calmodulin binding and autoinhibition.
J. Biol. Chem.
284
15573-15588
2009
2518
Martin A.C.,Willoughby D.,Ciruela A.,Ayling L.J.,Pagano M.,Wachten S.,Tengholm A.,Cooper D.M.
Capacitative Ca2+ entry via Orai1 and stromal interacting molecule 1 (STIM1) regulates adenylyl cyclase type 8.
Mol. Pharmacol.
75
830-842
2009
2519
Willoughby D.,Masada N.,Wachten S.,Pagano M.,Halls M.L.,Everett K.L.,Ciruela A.,Cooper D.M.
AKAP79/150 interacts with AC8 and regulates Ca2+-dependent cAMP synthesis in pancreatic and neuronal systems.
J. Biol. Chem.
285
20328-20342
2010
2520
Roger B.,Papin J.,Vacher P.,Raoux M.,Mulot A.,Dubois M.,Kerr-Conte J.,Voy B.H.,Pattou F.,Charpentier G.,Jonas J.C.,Moustaid-Moussa N.,Lang J.
Adenylyl cyclase 8 is central to glucagon-like peptide 1 signalling and effects of chronically elevated glucose in rat and human pancreatic beta cells.
Diabetologia
54
390-402
2011
2521
Delint-Ramirez I.,Willoughby D.,Hammond G.V.,Ayling L.J.,Cooper D.M.
Palmitoylation targets AKAP79 protein to lipid rafts and promotes its regulation of calcium-sensitive adenylyl cyclase type 8.
J. Biol. Chem.
286
32962-32975
2011
2522
Ayling L.J.,Briddon S.J.,Halls M.L.,Hammond G.R.,Vaca L.,Pacheco J.,Hill S.J.,Cooper D.M.
Adenylyl cyclase AC8 directly controls its micro-environment by recruiting the actin cytoskeleton in a cholesterol-rich milieu.
J. Cell Sci.
125
869-886
2012
2523
Willoughby D.,Halls M.L.,Everett K.L.,Ciruela A.,Skroblin P.,Klussmann E.,Cooper D.M.
A key phosphorylation site in AC8 mediates regulation of Ca(2+)-dependent cAMP dynamics by an AC8-AKAP79-PKA signalling complex.
J. Cell Sci.
125
5850-5859
2012
2524
Lundby A.,Secher A.,Lage K.,Nordsborg N.B.,Dmytriyev A.,Lundby C.,Olsen J.V.
Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.
Nat. Commun.
3
876-876
2012
2525
Willoughby D.,Everett K.L.,Halls M.L.,Pacheco J.,Skroblin P.,Vaca L.,Klussmann E.,Cooper D.M.
Direct binding between Orai1 and AC8 mediates dynamic interplay between Ca2+ and cAMP signaling.
Sci. Signal.
5
0-0
2012
2526
Everett K.L.,Cooper D.M.
An improved targeted cAMP sensor to study the regulation of adenylyl cyclase 8 by Ca2+ entry through voltage-gated channels.
PLoS ONE
8
0-0
2013
2527
Dou H.,Wang C.,Wu X.,Yao L.,Zhang X.,Teng S.,Xu H.,Liu B.,Wu Q.,Zhang Q.,Hu M.,Wang Y.,Wang L.,Wu Y.,Shang S.,Kang X.,Zheng L.,Zhang J.,Raoux M.,Lang J.,Li Q.,Su J.,Yu X.,Chen L.,Zhou Z.
Calcium influx activates adenylyl cyclase 8 for sustained insulin secretion in rat pancreatic beta cells.
Diabetologia
58
324-333
2015
