Sequence of TYSY_HUMAN
EC Number:2.1.1.45
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP
Other sequences found for EC No. 2.1.1.45
General information:
Sequence
0 MPVAGSELPR RPLPPAAQER DAEPRPPHGE LQYLGQIQHI LRCGVRKDDR TGTGTLSVFG
60 MQARYSLRDE FPLLTTKRVF WKGVLEELLW FIKGSTNAKE LSSKGVKIWD ANGSRDFLDS
120 LGFSTREEGD LGPVYGFQWR HFGAEYRDME SDYSGQGVDQ LQRVIDTIKT NPDDRRIIMC
180 AWNPRDLPLM ALPPCHALCQ FYVVNSELSC QLYQRSGDMG LGVPFNIASY ALLTYMIAHI
240 TGLKPGDFIH TLGDAHIYLN HIEPLKIQLQ REPRPFPKLR ILRKVEKIDD FKAEDFQIEG
300 YNPHPTIKME MAV
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
246015
Takeishi K.,Kaneda S.,Ayusawa D.,Shimizu K.,Gotoh O.,Seno T.
Nucleotide sequence of a functional cDNA for human thymidylate synthase.
Nucleic Acids Res.
13
2035-2043
1985
246016
Kaneda S.,Nalbantoglu J.,Takeishi K.,Shimizu K.,Gotoh O.,Seno T.,Ayusawa D.
Structural and functional analysis of the human thymidylate synthase gene.
J. Biol. Chem.
265
20277-20284
1990
246017
Hisatomi H.,Tanemura H.,Iizuka T.,Katsumata K.,Nagao K.,Sumida H.,Udagawa H.,Hikiji K.
Differential alternative splicing expressions of thymidylate synthase isoforms.
Cancer Lett.
193
127-131
2003
246019
Nusbaum C.,Zody M.C.,Borowsky M.L.,Kamal M.,Kodira C.D.,Taylor T.D.,Whittaker C.A.,Chang J.L.,Cuomo C.A.,Dewar K.,FitzGerald M.G.,Yang X.,Abouelleil A.,Allen N.R.,Anderson S.,Bloom T.,Bugalter B.,Butler J.,Cook A.,DeCaprio D.,Engels R.,Garber M.,Gnirke A.,Hafez N.,Hall J.L.,Norman C.H.,Itoh T.,Jaffe D.B.,Kuroki Y.,Lehoczky J.,Lui A.,Macdonald P.,Mauceli E.,Mikkelsen T.S.,Naylor J.W.,Nicol R.,Nguyen C.,Noguchi H.,O'Leary S.B.,Piqani B.,Smith C.L.,Talamas J.A.,Topham K.,Totoki Y.,Toyoda A.,Wain H.M.,Young S.K.,Zeng Q.,Zimmer A.R.,Fujiyama A.,Hattori M.,Birren B.W.,Sakaki Y.,Lander E.S.
DNA sequence and analysis of human chromosome 18.
Nature
437
551-555
2005
246021
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
246022
Takeishi K.,Kaneda S.,Ayusawa D.,Shimizu K.,Gotoh O.,Seno T.
Human thymidylate synthase gene: isolation of phage clones which cover a functionally active gene and structural analysis of the region upstream from the translation initiation codon.
J. Biochem.
106
575-583
1989
246023
Shimizu K.,Ayusawa D.,Takeishi K.,Seno T.
Purification and NH2-terminal amino acid sequence of human thymidylate synthase in an overproducing transformant of mouse FM3A cells.
J. Biochem.
97
845-850
1985
246024
Davisson V.J.,Sirawaraporn W.,Santi D.V.
Expression of human thymidylate synthase in Escherichia coli.
J. Biol. Chem.
264
9145-9148
1989
246025
Mayya V.,Lundgren D.H.,Hwang S.-I.,Rezaul K.,Wu L.,Eng J.K.,Rodionov V.,Han D.K.
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Sci. Signal.
2
0-0
2009
246026
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
246027
Anderson D.D.,Quintero C.M.,Stover P.J.
Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria.
Proc. Natl. Acad. Sci. U.S.A.
108
15163-15168
2011
246028
Van Damme P.,Lasa M.,Polevoda B.,Gazquez C.,Elosegui-Artola A.,Kim D.S.,De Juan-Pardo E.,Demeyer K.,Hole K.,Larrea E.,Timmerman E.,Prieto J.,Arnesen T.,Sherman F.,Gevaert K.,Aldabe R.
N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
Proc. Natl. Acad. Sci. U.S.A.
109
12449-12454
2012
246029
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
J. Proteome Res.
12
260-271
2013
246030
Hendriks I.A.,Lyon D.,Young C.,Jensen L.J.,Vertegaal A.C.,Nielsen M.L.
Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
Nat. Struct. Mol. Biol.
24
325-336
2017
246031
Schiffer C.A.,Clifton I.J.,Davisson V.J.,Santi D.V.,Stroud R.M.
Crystal structure of human thymidylate synthase: a structural mechanism for guiding substrates into the active site.
Biochemistry
34
16279-16287
1995
246032
Phan J.,Koli S.,Minor W.,Dunlap R.B.,Berger S.H.,Lebioda L.
Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug.
Biochemistry
40
1897-1902
2001
246033
Phan J.,Steadman D.J.,Koli S.,Ding W.C.,Minor W.,Dunlap R.B.,Berger S.H.,Lebioda L.
Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors.
J. Biol. Chem.
276
14170-14177
2001
