Sequence of TOM1_YEAST
EC Number:2.3.2.26
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
HECT-type E3 ubiquitin transferase
Q03280
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
3268
374185
Reaction
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine
Other sequences found for EC No. 2.3.2.26
General information:
Sequence
0 MVLFTRCEKA RKEKLAAGYK PLVDYLIDCD TPTFLERIEA IQEWDRSRDD LYVWIPILDR
60 MDGLLLKVAE KYKYKQDPKK ECEVKLVEME AHDVDYCLKM LKFTRRLLLN TENRFVYSSG
120 DVLMYLLNCP NFTIKLAVMR ILAILGERFV IAREKIVAHN IFGDHNLRKK TLKLALSLSS
180 SVMDEDGEHF SLVDLYFDKK KVPQKWRKLR FTHYTSNDFK KSSQQKNNIN ETQTSIKKVT
240 MTTQELCEHS LQQIFDKGMA LLPAESWFDF SIKASVAKAF SDDSGENIDL RNIIIETKLN
300 AIAFVNTIFS PPQVSSKLFE LDPYAFNSLT DLISLSETKI PKELRTDALF TLECISLKHV
360 WCSDIIRNLG GNISHGLLFQ ILRYIAKTLR EATDEIDEEY NVRFFYLISN LADVKPLHES
420 LFAAGLIPTL LEIVSIRNCP YKRTLASATH LLETFIDNSE TTTEFIENDG FTMLITSVAN
480 EIDFTLAHPE TWQPPKYSVV YYSISFRELA YIRSLLKLVL KLLSTDSGDR IRNLIDSPIL
540 VSLKKILENK LVFGLTLITY TLDVVQKVIN SEPTIYPVLV EAGLIPYVID NFPKLIGPSA
600 ELLSLLPDVV SAICLNPEGL KQVKEKGLIN NLFDFLLDAD HARILTGGDR STEYGTDIDE
660 LARHYPDLKA NIVEALCNVI RKMPSTFRNE REFLFTSPKD QKYFFHRKNE EILTDKEEHE
720 PAYWELLDKG TMLDTFTSVL FGMSLGNGSF SQVPQHLEAR DFLAIIFMEN PPYEYFTSVA
780 ISNVTEVLQY LDEKYEDYAF MDVMKVLNDQ LENLNDFLNS PNDRSFFLER DGENSVRSCH
840 SKLCRLAAIL NIVTNVYIDL TTLSCKRIMQ IYSYFDKRGF SLIKNLKLLF QKCALEEMYI
900 RQHMPDSVIT ETMPLPIVDV SGDGPPLQIY IDDPKKGDQK GKITSVKTRN TLQMRTILYT
960 LQSNTAILFR CFLRLSHSRN MDLEHKDLTT EVHIFENVVE NVIEMLKATE LEGHLPYILV
1020 LLNFNTFVFT IPKASPNSTE ILQTIPAYIF YQKGGYLLYL HIIRDLFTRM TKIKDLSSLD
1080 NINYIDESNG ILTLSCLINA LTFYNKSMQT ETMENVQSIG KYYVSIDDDY NIMKALTVPI
1140 KVMALAMILD LDKSDSLFKT QSRNVPYSVF KQLLSMLKNI FTNVNIYTKE LYELHWDLIF
1200 PPIKKISLFE QVGIPGDVAA NYLTDTGDDL PADNSIGLFS PEQWEKYKKL IGEDKSIYYP
1260 QPMQAQYYKG CSSKELDELR DTFFNDGLPS RIFTVLPFYP KLVNAFAKTL LQIFTKYDEP
1320 TEVFAGRILD RILETDLDDP ATLSSLIHLF GIFLNEKYIY QKASHLMQRF IEYLEKSLKP
1380 EHVNTPWFSK ALYVYEIILA KSELPHLEEL SKDVLLRYPL LSMAKVFRIP DPMKQKLFDI
1440 LIRVSDISNF YSALATSRIL IFYSRDELYA NNIARSGILS RLLKVIGSFQ KLDKINFLES
1500 SFLLLTRRCF ETTENVDALI RAEINRSFTA RPLGGGDDAV RELTTILEEK AHVVMRSPSQ
1560 FIDVLCETAR FHEFDDQGAL VDYSLKRFLG EKDKNTQASS TEKSDIYERT GIMHLLLSQL
1620 MAASEKDWLS EPANSSDLPE NKKAQLDPSR NPVCAYMIFL LKLLVELVSS YNQCKFEFLT
1680 FSRRNTYAER PRPRTTAINF FLYRLLDKPV GTDHDKHEAK RREVIGMLAR SVIIGFLATV
1740 QDDRTTKTDV KLADPHMNFI RKFAIEAIIK AIRNATSSSK LLESNHLKLD MWFRIITSMV
1800 YVQAPYLRQL LDSNKVEADQ YQLCKLVIDL GLPSVITEAM ASIDLNYPFS KKIFNVAVEA
1860 LNTISSTRNN FSEHFKIEDH DEVEDEVDES DKEEIPDMFK NSALGMYDVE DIEEDDDDDT
1920 SLIGDDDAMA FVDSDNGFEV VFSDEDDDMG EEDADDARSD SEENELSSEM QSSTADGTDV
1980 DYEVDDADGL IINIDQPSGD DEEMADYDAN ISHSSHSENE DDASMDVIEV YDDELSSGYD
2040 VDLSDYDVDE SDWDSGLSSL SISDEDSESS EDEPINSTRM GDSRRRWLIA EGVELTDDSQ
2100 GESEEDDRGV FRGIEHIFSN ENEPLFRVHD EMRHRNHHRS INRTHFHSAM SAPSLSLLNR
2160 GRRNQSNLIN PLGPTGLEQV ENDISDQVTV AGSGSRPRSH HLHFSEVLVS GSFFDEPVLD
2220 GIILKSTVSR WKDIFDMFYD SKTYANCIIP TVINRLYKVS LALQKDLENK REQEKLKNKN
2280 LLFNEAKVES HNSSDAISVE QDDIQESNVT HDDHEPVYVT IQGSEVDIGG TDIDPEFMNA
2340 LPDDIRADVF AQHVRERRAE ARLNSDHNVH SREIDSDFLE AIPEDIREGI LDTEAEEQRM
2400 FGRIGSSADV IRADDDVSNN DEEVENGLDH GNSNDRNNAD PEKKKPARIY FAPLIDRAGI
2460 ASLMKSVFIS KPYIQREIYH ELFYRLCSSK QNRNDLMNTF LFILSEGIID QHSLEKVYNI
2520 ISSRAMGHAK TTTVRQLPSD CTPLTVANQT IEILQSLIDA DSRLKYFLIA EHDNLIVNKA
2580 NNKSRKEALP DKKLRWPLWH LFSLLDRKLI TDESVLMDLL TRILQVCTKT LAVLSTSSNG
2640 KENLSKKFHL PSFDEDDLMK ILSIIMLDSC TTRVFQQTLN IIYNLSKLQG CMSIFTKHLV
2700 SLAISIMSKL KSALDGLSRE VGTITTGMEI NSELLQKFTL PSSDQAKLLK ILTTVDFLYT
2760 HKRKEEERNV KDLQSLYDKM NGGPVWSSLS ECLSQFEKSQ AINTSATILL PLIESLMVVC
2820 RRSDLSQNRN TAVKYEDAKL LDFSKTRVEN LFFPFTDAHK KLLNQMIRSN PKLMSGPFAL
2880 LVKNPKVLDF DNKRYFFNAK LKSDNQERPK LPITVRREQV FLDSYRALFF KTNDEIKNSK
2940 LEITFKGESG VDAGGVTREW YQVLSRQMFN PDYALFLPVP SDKTTFHPNR TSGINPEHLS
3000 FFKFIGMIIG KAIRDQCFLD CHFSREVYKN ILGRPVSLKD MESLDPDYYK SLVWILENDI
3060 TDIIEETFSV ETDDYGEHKV INLIEGGKDI IVTEANKQDY VKKVVEYKLQ TSVKEQMDNF
3120 LVGFYALISK DLITIFDEQE LELLISGLPD IDVDDWKNNT TYVNYTATCK EVSYFWRAVR
3180 SFDAEERAKL LQFVTGTSKV PLNGFKELSG VNGVCKFSIH RDFGSSERLP SSHTCFNQLN
3240 LPPYESYETL RGSLLLAINE GHEGFGLA
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
242613
Jacq C.,Alt-Moerbe J.,Andre B.,Arnold W.,Bahr A.,Ballesta J.P.G.,Bargues M.,Baron L.,Becker A.,Biteau N.,Bloecker H.,Blugeon C.,Boskovic J.,Brandt P.,Brueckner M.,Buitrago M.J.,Coster F.,Delaveau T.,del Rey F.,Dujon B.,Eide L.G.,Garcia-Cantalejo J.M.,Goffeau A.,Gomez-Peris A.,Granotier C.,Hanemann V.,Hankeln T.,Hoheisel J.D.,Jaeger W.,Jimenez A.,Jonniaux J.-L.,Kraemer C.,Kuester H.,Laamanen P.,Legros Y.,Louis E.J.,Moeller-Rieker S.,Monnet A.,Moro M.,Mueller-Auer S.,Nussbaumer B.,Paricio N.,Paulin L.,Perea J.,Perez-Alonso M.,Perez-Ortin J.E.,Pohl T.M.,Prydz H.,Purnelle B.,Rasmussen S.W.,Remacha M.A.,Revuelta J.L.,Rieger M.,Salom D.,Saluz H.P.,Saiz J.E.,Saren A.-M.,Schaefer M.,Scharfe M.,Schmidt E.R.,Schneider C.,Scholler P.,Schwarz S.,Soler-Mira A.,Urrestarazu L.A.,Verhasselt P.,Vissers S.,Voet M.,Volckaert G.,Wagner G.,Wambutt R.,Wedler E.,Wedler H.,Woelfl S.,Harris D.E.,Bowman S.,Brown D.,Churcher C.M.,Connor R.,Dedman K.,Gentles S.,Hamlin N.,Hunt S.,Jones L.,McDonald S.,Murphy L.D.,Niblett D.,Odell C.,Oliver K.,Rajandream M.A.,Richards C.,Shore L.,Walsh S.V.,Barrell B.G.,Dietrich F.S.,Mulligan J.T.,Allen E.,Araujo R.,Aviles E.,Berno A.,Carpenter J.,Chen E.,Cherry J.M.,Chung E.,Duncan M.,Hunicke-Smith S.,Hyman R.W.,Komp C.,Lashkari D.,Lew H.,Lin D.,Mosedale D.,Nakahara K.,Namath A.,Oefner P.,Oh C.,Petel F.X.,Roberts D.,Schramm S.,Schroeder M.,Shogren T.,Shroff N.,Winant A.,Yelton M.A.,Botstein D.,Davis R.W.,Johnston M.,Andrews S.,Brinkman R.,Cooper J.,Ding H.,Du Z.,Favello A.,Fulton L.,Gattung S.,Greco T.,Hallsworth K.,Hawkins J.,Hillier L.W.,Jier M.,Johnson D.,Johnston L.,Kirsten J.,Kucaba T.,Langston Y.,Latreille P.,Le T.,Mardis E.,Menezes S.,Miller N.,Nhan M.,Pauley A.,Peluso D.,Rifkin L.,Riles L.,Taich A.,Trevaskis E.,Vignati D.,Wilcox L.,Wohldman P.,Vaudin M.,Wilson R.,Waterston R.,Albermann K.,Hani J.,Heumann K.,Kleine K.,Mewes H.-W.,Zollner A.,Zaccaria P.
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Nature
387
75-78
1997
242614
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G3 (Bethesda)
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2014
242615
Utsugi T.,Hirata A.,Sekiguchi Y.,Sasaki T.,Toh-e A.,Kikuchi Y.
Yeast tom1 mutant exhibits pleiotropic defects in nuclear division, maintenance of nuclear structure and nucleocytoplasmic transport at high temperatures.
Gene
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285-295
1999
242616
Saleh A.,Collart M.,Martens J.A.,Genereaux J.,Allard S.,Cote J.,Brandl C.J.
TOM1p, a yeast hect-domain protein which mediates transcriptional regulation through the ADA/SAGA coactivator complexes.
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282
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1998
242617
Sasaki T.,Toh-e A.,Kikuchi Y.
Extragenic suppressors that rescue defects in the heat stress response of the budding yeast mutant tom1.
Mol. Gen. Genet.
262
940-948
2000
242618
Duncan K.,Umen J.G.,Guthrie C.
A putative ubiquitin ligase required for efficient mRNA export differentially affects hnRNP transport.
Curr. Biol.
10
687-696
2000
242619
Sasaki T.,Toh-e A.,Kikuchi Y.
Yeast Krr1p physically and functionally interacts with a novel essential Kri1p, and both proteins are required for 40S ribosome biogenesis in the nucleolus.
Mol. Cell. Biol.
20
7971-7979
2000
242620
Tabb A.L.,Utsugi T.,Wooten-Kee C.R.,Sasaki T.,Edling S.A.,Gump W.,Kikuchi Y.,Ellis S.R.
Genes encoding ribosomal proteins Rps0A/B of Saccharomyces cerevisiae interact with TOM1 mutants defective in ribosome synthesis.
Genetics
157
1107-1116
2001
242621
Huh W.-K.,Falvo J.V.,Gerke L.C.,Carroll A.S.,Howson R.W.,Weissman J.S.,O'Shea E.K.
Global analysis of protein localization in budding yeast.
Nature
425
686-691
2003
242622
Ghaemmaghami S.,Huh W.-K.,Bower K.,Howson R.W.,Belle A.,Dephoure N.,O'Shea E.K.,Weissman J.S.
Global analysis of protein expression in yeast.
Nature
425
737-741
2003
242623
Li X.,Gerber S.A.,Rudner A.D.,Beausoleil S.A.,Haas W.,Villen J.,Elias J.E.,Gygi S.P.
Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.
J. Proteome Res.
6
1190-1197
2007
242624
Albuquerque C.P.,Smolka M.B.,Payne S.H.,Bafna V.,Eng J.,Zhou H.
A multidimensional chromatography technology for in-depth phosphoproteome analysis.
Mol. Cell. Proteomics
7
1389-1396
2008
242625
Holt L.J.,Tuch B.B.,Villen J.,Johnson A.D.,Gygi S.P.,Morgan D.O.
Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.
Science
325
1682-1686
2009
