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Sequence of RN125_HUMAN

EC Number:2.3.2.27

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
2.3.2.27
RING-type E3 ubiquitin transferase
Q96EQ8
Homo sapiens
232
26454
Swiss-Prot
Reaction
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine
Other sequences found for EC No. 2.3.2.27

General information:

Sequence
show sequence in fasta format
  0 MGSVLSTDSG KSAPASATAR ALERRRDPEL PVTSFDCAVC LEVLHQPVRT RCGHVFCRSC
 60 IATSLKNNKW TCPYCRAYLP SEGVPATDVA KRMKSEYKNC AECDTLVCLS EMRAHIRTCQ
120 KYIDKYGPLQ ELEETAARCV CPFCQRELYE DSLLDHCITH HRSERRPVFC PLCRLIPDEN
180 PSSFSGSLIR HLQVSHTLFY DDFIDFNIIE EALIRRVLDR SLLEYVNHSN TT
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
221842
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
14702039
221843
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
15489334
221844
Chu P.,Pardo J.,Zhao H.,Li C.C.,Pali E.,Shen M.M.,Qu K.,Yu S.X.,Huang B.C.B.,Yu P.,Masuda E.S.,Molineaux S.M.,Kolbinger F.,Aversa G.,de Vries J.,Payan D.G.,Liao X.C.
Systematic identification of regulatory proteins critical for T-cell activation.
J. Biol.
2
0-0
2003
12974981
221845
Zhao H.,Li C.C.,Pardo J.,Chu P.C.,Liao C.X.,Huang J.,Dong J.G.,Zhou X.,Huang Q.,Huang B.C.B.,Bennett M.K.,Molineaux S.M.,Lu H.,Daniel-Issakani S.,Payan D.G.,Masuda E.S.
A novel E3 ubiquitin ligase TRAC-1 positively regulates T cell activation.
J. Immunol.
174
5288-5297
2005
15843525
221846
Arimoto K.,Takahashi H.,Hishiki T.,Konishi H.,Fujita T.,Shimotohno K.
Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125.
Proc. Natl. Acad. Sci. U.S.A.
104
7500-7505
2007
17460044
221847
Shoji-Kawata S.,Zhong Q.,Kameoka M.,Iwabu Y.,Sapsutthipas S.,Luftig R.B.,Ikuta K.
The RING finger ubiquitin ligase RNF125/TRAC-1 down-modulates HIV-1 replication in primary human peripheral blood mononuclear cells.
Virology
368
191-204
2007
17643463
221848
Giannini A.L.,Gao Y.,Bijlmakers M.J.
T-cell regulator RNF125/TRAC-1 belongs to a novel family of ubiquitin ligases with zinc fingers and a ubiquitin-binding domain.
Biochem. J.
410
101-111
2008
17990982
221849
Tenorio J.,Mansilla A.,Valencia M.,Martinez-Glez V.,Romanelli V.,Arias P.,Castrejon N.,Poletta F.,Guillen-Navarro E.,Gordo G.,Mansilla E.,Garcia-Santiago F.,Gonzalez-Casado I.,Vallespin E.,Palomares M.,Mori M.A.,Santos-Simarro F.,Garcia-Minaur S.,Fernandez L.,Mena R.,Benito-Sanz S.,del Pozo A.,Silla J.C.,Ibanez K.,Lopez-Granados E.,Martin-Trujillo A.,Montaner D.,Heath K.E.,Campos-Barros A.,Dopazo J.,Nevado J.,Monk D.,Ruiz-Perez V.L.,Lapunzina P.
A new overgrowth syndrome is due to mutations in RNF125.
Hum. Mutat.
35
1436-1441
2014
25196541
221850
Yang L.,Zhou B.,Li X.,Lu Z.,Li W.,Huo X.,Miao Z.
RNF125 is a ubiquitin-protein ligase that promotes p53 degradation.
Cell. Physiol. Biochem.
35
237-245
2015
25591766
221851
Kim H.,Frederick D.T.,Levesque M.P.,Cooper Z.A.,Feng Y.,Krepler C.,Brill L.,Samuels Y.,Hayward N.K.,Perlina A.,Piris A.,Zhang T.,Halaban R.,Herlyn M.M.,Brown K.M.,Wargo J.A.,Dummer R.,Flaherty K.T.,Ronai Z.A.
Downregulation of the ubiquitin ligase RNF125 underlies resistance of melanoma cells to BRAF inhibitors via JAK1 deregulation.
Cell Rep.
11
1458-1473
2015
26027934
221852
Hao Q.,Jiao S.,Shi Z.,Li C.,Meng X.,Zhang Z.,Wang Y.,Song X.,Wang W.,Zhang R.,Zhao Y.,Wong C.C.,Zhou Z.
A non-canonical role of the p97 complex in RIG-I antiviral signaling.
EMBO J.
34
2903-2920
2015
26471729
221853
Zhu B.,Ye J.,Nie Y.,Ashraf U.,Zohaib A.,Duan X.,Fu Z.F.,Song Y.,Chen H.,Cao S.
MicroRNA-15b Modulates Japanese Encephalitis Virus-Mediated Inflammation via Targeting RNF125.
J. Immunol.
195
2251-2262
2015
26202983
221854
Bijlmakers M.J.,Teixeira J.M.,Boer R.,Mayzel M.,Puig-Sarries P.,Karlsson G.,Coll M.,Pons M.,Crosas B.
A C2HC zinc finger is essential for the RING-E2 interaction of the ubiquitin ligase RNF125.
Sci. Rep.
6
29232-29232
2016
27411375