Any feedback?
Please rate this page
(sequences.php)
(0/150)

BRENDA support

Sequence of POLN_EEVVT

EC Number:2.7.7.48

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
2.7.7.48
RNA-directed RNA polymerase
P27282
Venezuelan equine encephalitis virus (strain Trinidad donkey)
2493
277887
Swiss-Prot
Reaction
nucleoside triphosphate + RNAn = diphosphate + RNAn+1
Other sequences found for EC No. 2.7.7.48

General information:

Sequence
show sequence in fasta format
   0 MEKVHVDIEE DSPFLRALQR SFPQFEVEAK QVTDNDHANA RAFSHLASKL IETEVDPSDT
  60 ILDIGSAPAR RMYSKHKYHC ICPMRCAEDP DRLYKYATKL KKNCKEITDK ELDKKMKELA
 120 AVMSDPDLET ETMCLHDDES CRYEGQVAVY QDVYAVDGPT SLYHQANKGV RVAYWIGFDT
 180 TPFMFKNLAG AYPSYSTNWA DETVLTARNI GLCSSDVMER SRRGMSILRK KYLKPSNNVL
 240 FSVGSTIYHE KRDLLRSWHL PSVFHLRGKQ NYTCRCETIV SCDGYVVKRI AISPGLYGKP
 300 SGYAATMHRE GFLCCKVTDT LNGERVSFPV CTYVPATLCD QMTGILATDV SADDAQKLLV
 360 GLNQRIVVNG RTQRNTNTMK NYLLPVVAQA FARWAKEYKE DQEDERPLGL RDRQLVMGCC
 420 WAFRRHKITS IYKRPDTQTI IKVNSDFHSF VLPRIGSNTL EIGLRTRIRK MLEEHKEPSP
 480 LITAEDVQEA KCAADEAKEV REAEELRAAL PPLAADVEEP TLEADVDLML QEAGAGSVET
 540 PRGLIKVTSY AGEDKIGSYA VLSPQAVLKS EKLSCIHPLA EQVIVITHSG RKGRYAVEPY
 600 HGKVVVPEGH AIPVQDFQAL SESATIVYNE REFVNRYLHH IATHGGALNT DEEYYKTVKP
 660 SEHDGEYLYD IDRKQCVKKE LVTGLGLTGE LVDPPFHEFA YESLRTRPAA PYQVPTIGVY
 720 GVPGSGKSGI IKSAVTKKDL VVSAKKENCA EIIRDVKKMK GLDVNARTVD SVLLNGCKHP
 780 VETLYIDEAF ACHAGTLRAL IAIIRPKKAV LCGDPKQCGF FNMMCLKVHF NHEICTQVFH
 840 KSISRRCTKS VTSVVSTLFY DKKMRTTNPK ETKIVIDTTG STKPKQDDLI LTCFRGWVKQ
 900 LQIDYKGNEI MTAAASQGLT RKGVYAVRYK VNENPLYAPT SEHVNVLLTR TEDRIVWKTL
 960 AGDPWIKTLT AKYPGNFTAT IEEWQAEHDA IMRHILERPD PTDVFQNKAN VCWAKALVPV
1020 LKTAGIDMTT EQWNTVDYFE TDKAHSAEIV LNQLCVRFFG LDLDSGLFSA PTVPLSIRNN
1080 HWDNSPSPNM YGLNKEVVRQ LSRRYPQLPR AVATGRVYDM NTGTLRNYDP RINLVPVNRR
1140 LPHALVLHHN EHPQSDFSSF VSKLKGRTVL VVGEKLSVPG KMVDWLSDRP EATFRARLDL
1200 GIPGDVPKYD IIFVNVRTPY KYHHYQQCED HAIKLSMLTK KACLHLNPGG TCVSIGYGYA
1260 DRASESIIGA IARQFKFSRV CKPKSSLEET EVLFVFIGYD RKARTHNPYK LSSTLTNIYT
1320 GSRLHEAGCA PSYHVVRGDI ATATEGVIIN AANSKGQPGG GVCGALYKKF PESFDLQPIE
1380 VGKARLVKGA AKHIIHAVGP NFNKVSEVEG DKQLAEAYES IAKIVNDNNY KSVAIPLLST
1440 GIFSGNKDRL TQSLNHLLTA LDTTDADVAI YCRDKKWEMT LKEAVARREA VEEICISDDS
1500 SVTEPDAELV RVHPKSSLAG RKGYSTSDGK TFSYLEGTKF HQAAKDIAEI NAMWPVATEA
1560 NEQVCMYILG ESMSSIRSKC PVEESEASTP PSTLPCLCIH AMTPERVQRL KASRPEQITV
1620 CSSFPLPKYR ITGVQKIQCS QPILFSPKVP AYIHPRKYLV ETPPVDETPE PSAENQSTEG
1680 TPEQPPLITE DETRTRTPEP IIIEEEEEDS ISLLSDGPTH QVLQVEADIH GPPSVSSSSW
1740 SIPHASDFDV DSLSILDTLE GASVTSGATS AETNSYFAKS MEFLARPVPA PRTVFRNPPH
1800 PAPRTRTPSL APSRACSRTS LVSTPPGVNR VITREELEAL TPSRTPSRSV SRTSLVSNPP
1860 GVNRVITREE FEAFVAQQQX RFDAGAYIFS SDTGQGHLQQ KSVRQTVLSE VVLERTELEI
1920 SYAPRLDQEK EELLRKKLQL NPTPANRSRY QSRKVENMKA ITARRILQGL GHYLKAEGKV
1980 ECYRTLHPVP LYSSSVNRAF SSPKVAVEAC NAMLKENFPT VASYCIIPEY DAYLDMVDGA
2040 SCCLDTASFC PAKLRSFPKK HSYLEPTIRS AVPSAIQNTL QNVLAAATKR NCNVTQMREL
2100 PVLDSAAFNV ECFKKYACNN EYWETFKENP IRLTEENVVN YITKLKGPKA AALFAKTHNL
2160 NMLQDIPMDR FVMDLKRDVK VTPGTKHTEE RPKVQVIQAA DPLATAYLCG IHRELVRRLN
2220 AVLLPNIHTL FDMSAEDFDA IIAEHFQPGD CVLETDIASF DKSEDDAMAL TALMILEDLG
2280 VDAELLTLIE AAFGEISSIH LPTKTKFKFG AMMKSGMFLT LFVNTVINIV IASRVLRERL
2340 TGSPCAAFIG DDNIVKGVKS DKLMADRCAT WLNMEVKIID AVVGEKAPYF CGGFILCDSV
2400 TGTACRVADP LKRLFKLGKP LAADDEHDDD RRRALHEEST RWNRVGILSE LCKAVESRYE
2460 TVGTSIIVMA MTTLASSVKS FSYLRGAPIT LYG
Download this sequence
in fasta format
Download all sequences for 2.7.7.48
in fasta format
in csv (Excel, OpenOffice) format
Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
207548
Kinney R.M.,Johnson B.J.B.,Welch J.B.,Tsuchiya K.R.,Trent D.W.
The full-length nucleotide sequences of the virulent Trinidad donkey strain of Venezuelan equine encephalitis virus and its attenuated vaccine derivative, strain TC-83.
Virology
170
19-30
1989
2524126
207550
Kinney R.M.,Tsuchiya K.R.,Sneider J.M.,Trent D.W.
Molecular evidence for the origin of the widespread Venezuelan equine encephalitis epizootic of 1969 to 1972.
J. Gen. Virol.
73
3301-3305
1992
1469368
207553
Montgomery S.A.,Johnston R.E.
Nuclear import and export of Venezuelan equine encephalitis virus nonstructural protein 2.
J. Virol.
81
10268-10279
2007
17652399
207554
Kim D.Y.,Atasheva S.,Frolova E.I.,Frolov I.
Venezuelan equine encephalitis virus nsP2 protein regulates packaging of the viral genome into infectious virions.
J. Virol.
87
4202-4213
2013
23365438
207555
Li C.,Guillen J.,Rabah N.,Blanjoie A.,Debart F.,Vasseur J.J.,Canard B.,Decroly E.,Coutard B.
mRNA capping by venezuelan equine encephalitis virus nsp1: functional characterization and implications for antiviral research.
J. Virol.
89
8292-8303
2015
26041283
207556
Amaya M.,Brooks-Faulconer T.,Lark T.,Keck F.,Bailey C.,Raman V.,Narayanan A.
Venezuelan equine encephalitis virus non-structural protein 3 (nsP3) interacts with RNA helicases DDX1 and DDX3 in infected cells.
Antiviral Res.
131
49-60
2016
27105836
207557
Bhalla N.,Sun C.,Metthew Lam L.K.,Gardner C.L.,Ryman K.D.,Klimstra W.B.
Host translation shutoff mediated by non-structural protein 2 is a critical factor in the antiviral state resistance of Venezuelan equine encephalitis virus.
Virology
496
147-165
2016
27318152
207558
Kim D.Y.,Reynaud J.M.,Rasalouskaya A.,Akhrymuk I.,Mobley J.A.,Frolov I.,Frolova E.I.
New World and Old World Alphaviruses Have Evolved to Exploit Different Components of Stress Granules, FXR and G3BP Proteins, for Assembly of Viral Replication Complexes.
PLoS Pathog.
12
0-0
2016
27509095
207559
Li C.,Debing Y.,Jankevicius G.,Neyts J.,Ahel I.,Coutard B.,Canard B.
Viral Macro Domains Reverse Protein ADP-Ribosylation.
J. Virol.
90
8478-8486
2016
27440879
207560
Eckei L.,Krieg S.,Buetepage M.,Lehmann A.,Gross A.,Lippok B.,Grimm A.R.,Kuemmerer B.M.,Rossetti G.,Luescher B.,Verheugd P.
The conserved macrodomains of the non-structural proteins of Chikungunya virus and other pathogenic positive strand RNA viruses function as mono-ADP-ribosylhydrolases.
Sci. Rep.
7
41746-41746
2017
28150709
207561
Russo A.T.,White M.A.,Watowich S.J.
The crystal structure of the Venezuelan equine encephalitis alphavirus nsP2 protease.
Structure
14
1449-1458
2006
16962975
207562
Hu X.,Compton J.R.,Leary D.H.,Olson M.A.,Lee M.S.,Cheung J.,Ye W.,Ferrer M.,Southall N.,Jadhav A.,Morazzani E.M.,Glass P.J.,Marugan J.,Legler P.M.
Kinetic, Mutational, and Structural Studies of the Venezuelan Equine Encephalitis Virus Nonstructural Protein 2 Cysteine Protease.
Biochemistry
55
3007-3019
2016
27030368
207563
Compton J.R.,Mickey M.J.,Hu X.,Marugan J.J.,Legler P.M.
Mutation of Asn-475 in the Venezuelan equine encephalitis virus nsP2 cysteine protease leads to a self-inhibited state.
Biochemistry
56
6221-6230
2017
29064679