Sequence of CP4AA_RAT
EC Number:1.14.14.80
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
a long-chain fatty acid + [reduced NADPH-hemoprotein reductase] + O2 = an omega-hydroxy-long-chain fatty acid + [oxidized NADPH-hemoprotein reductase] + H2O
Other sequences found for EC No. 1.14.14.80
General information:
Sequence
0 MSVSALSSTR FTGSISGFLQ VASVLGLLLL LVKAVQFYLQ RQWLLKAFQQ FPSPPFHWFF
60 GHKQFQGDKE LQQIMTCVEN FPSAFPRWFW GSKAYLIVYD PDYMKVILGR SDPKANGVYR
120 LLAPWIGYGL LLLNGQPWFQ HRRMLTPAFH YDILKPYVKN MADSIRLMLD KWEQLAGQDS
180 SIEIFQHISL MTLDTVMKCA FSHNGSVQVD GNYKSYIQAI GNLNDLFHSR VRNIFHQNDT
240 IYNFSSNGHL FNRACQLAHD HTDGVIKLRK DQLQNAGELE KVKKKRRLDF LDILLLARME
300 NGDSLSDKDL RAEVDTFMFE GHDTTASGVS WIFYALATHP EHQQRCREEV QSVLGDGSSI
360 TWDHLDQIPY TTMCIKEALR LYPPVPGIVR ELSTSVTFPD GRSLPKGIQV TLSIYGLHHN
420 PKVWPNPEVF DPSRFAPDSP RHSHSFLPFS GGARNCIGKQ FAMSEMKVIV ALTLLRFELL
480 PDPTKVPIPL PRLVLKSKNG IYLYLKKLH
Download this sequence
in fasta formatDownload all sequences for 1.14.14.80
in fasta format
in csv (Excel, OpenOffice) formatSequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
20407
Hardwick J.P.,Song B.-J.,Huberman E.,Gonzalez F.J.
Isolation, complementary DNA sequence, and regulation of rat hepatic lauric acid omega-hydroxylase (cytochrome P-450LA omega). Identification of a new cytochrome P-450 gene family.
J. Biol. Chem.
262
801-810
1987
20408
Earnshaw D.,Dale J.W.,Goldfarb P.S.,Gibson G.G.
Differential splicing in the 3' non-coding region of rat cytochrome P-452 (P450 IVA1) mRNA.
FEBS Lett.
236
357-361
1988
20409
Kimura S.,Hanioka N.,Matsunaga E.,Gonzalez F.J.
The rat clofibrate-inducible CYP4A gene subfamily. I. Complete intron and exon sequence of the CYP4A1 and CYP4A2 genes, unique exon organization, and identification of a conserved 19-bp upstream element.
DNA
8
503-516
1989
20410
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
20411
Okita R.T.,Okita J.R.
Characterization of a cytochrome P450 from di(2-ethylhexyl) phthalate-treated rats which hydroxylates fatty acids.
Arch. Biochem. Biophys.
294
475-481
1992
20412
Nguyen X.,Wang M.H.,Reddy K.M.,Falck J.R.,Schwartzman M.L.
Kinetic profile of the rat CYP4A isoforms: arachidonic acid metabolism and isoform-specific inhibitors.
Am. J. Physiol.
276
0-0
1999
20413
Hoch U.,Zhang Z.,Kroetz D.L.,Ortiz de Montellano P.R.
Structural determination of the substrate specificities and regioselectivities of the rat and human fatty acid omega-hydroxylases.
Arch. Biochem. Biophys.
373
63-71
2000
20414
Hoch U.,Ortiz de Montellano P.R.
Covalently linked heme in cytochrome P4504A fatty acid hydroxylases.
J. Biol. Chem.
276
11339-11346
2001
20415
LeBrun L.A.,Hoch U.,Ortiz de Montellano P.R.
Autocatalytic mechanism and consequences of covalent heme attachment in the cytochrome P4504A family.
J. Biol. Chem.
277
12755-12761
2002
20416
Muller D.N.,Theuer J.,Shagdarsuren E.,Kaergel E.,Honeck H.,Park J.K.,Markovic M.,Barbosa-Sicard E.,Dechend R.,Wellner M.,Kirsch T.,Fiebeler A.,Rothe M.,Haller H.,Luft F.C.,Schunck W.H.
A peroxisome proliferator-activated receptor-alpha activator induces renal CYP2C23 activity and protects from angiotensin II-induced renal injury.
Am. J. Pathol.
164
521-532
2004
20417
Zhang F.,Chen C.L.,Qian J.Q.,Yan J.T.,Cianflone K.,Xiao X.,Wang D.W.
Long-term modifications of blood pressure in normotensive and spontaneously hypertensive rats by gene delivery of rAAV-mediated cytochrome P450 arachidonic acid hydroxylase.
Cell Res.
15
717-724
2005
