Sequence of NTRK1_RAT
EC Number:2.7.10.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Other sequences found for EC No. 2.7.10.1
General information:
Sequence
0 MLRGQRHGQL GWHRPAAGLG GLVTSLMLAC ACAASCRETC CPVGPSGLRC TRAGTLNTLR
60 GLRGAGNLTE LYVENQRDLQ RLEFEDLQGL GELRSLTIVK SGLRFVAPDA FHFTPRLSHL
120 NLSSNALESL SWKTVQGLSL QDLTLSGNPL HCSCALLWLQ RWEQEDLCGV YTQKLQGSGS
180 GDQFLPLGHN NSCGVPSVKI QMPNDSVEVG DDVFLQCQVE GQALQQADWI LTELEGTATM
240 KKSGDLPSLG LTLVNVTSDL NKKNVTCWAE NDVGRAEVSV QVSVSFPASV HLGKAVEQHH
300 WCIPFSVDGQ PAPSLRWFFN GSVLNETSFI FTQFLESALT NETMRHGCLR LNQPTHVNNG
360 NYTLLAANPY GQAAASIMAA FMDNPFEFNP EDPIPVSFSP VDTNSTSRDP VEKKDETPFG
420 VSVAVGLAVS AALFLSALLL VLNKCGQRSK FGINRPAVLA PEDGLAMSLH FMTLGGSSLS
480 PTEGKGSGLQ GHIMENPQYF SDTCVHHIKR QDIILKWELG EGAFGKVFLA ECYNLLNDQD
540 KMLVAVKALK ETSENARQDF HREAELLTML QHQHIVRFFG VCTEGGPLLM VFEYMRHGDL
600 NRFLRSHGPD AKLLAGGEDV APGPLGLGQL LAVASQVAAG MVYLASLHFV HRDLATRNCL
660 VGQGLVVKIG DFGMSRDIYS TDYYRVGGRT MLPIRWMPPE SILYRKFSTE SDVWSFGVVL
720 WEIFTYGKQP WYQLSNTEAI ECITQGRELE RPRACPPDVY AIMRGCWQRE PQQRLSMKDV
780 HARLQALAQA PPSYLDVLG
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
197421
Meakin S.O.,Suter U.,Drinkwater C.C.,Welcher A.A.,Shooter E.M.
The rat trk protooncogene product exhibits properties characteristic of the slow nerve growth factor receptor.
Proc. Natl. Acad. Sci. U.S.A.
89
2374-2378
1992
197422
Barker P.A.,Lomen-Hoerth C.,Gensch E.M.,Meakin S.O.,Glass D.J.,Shooter E.M.
Tissue-specific alternative splicing generates two isoforms of the trkA receptor.
J. Biol. Chem.
268
15150-15157
1993
197423
Hempstead B.L.,Martin-Zanca D.,Kaplan D.R.,Parada L.F.,Chao M.V.
High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor.
Nature
350
678-683
1991
197424
Stephens R.M.,Loeb D.M.,Copeland T.D.,Pawson T.,Greene L.A.,Kaplan D.R.
Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses.
Neuron
12
691-705
1994
197425
Qian X.,Riccio A.,Zhang Y.,Ginty D.D.
Identification and characterization of novel substrates of Trk receptors in developing neurons.
Neuron
21
1017-1029
1998
197426
Wooten M.W.,Seibenhener M.L.,Mamidipudi V.,Diaz-Meco M.T.,Barker P.A.,Moscat J.
The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor.
J. Biol. Chem.
276
7709-7712
2001
197427
Kong H.,Boulter J.,Weber J.L.,Lai C.,Chao M.V.
An evolutionarily conserved transmembrane protein that is a novel downstream target of neurotrophin and ephrin receptors.
J. Neurosci.
21
176-185
2001
197428
Geetha T.,Wooten M.W.
Association of the atypical protein kinase C-interacting protein p62/ZIP with nerve growth factor receptor TrkA regulates receptor trafficking and Erk5 signaling.
J. Biol. Chem.
278
4730-4739
2003
197429
Arevalo J.C.,Yano H.,Teng K.K.,Chao M.V.
A unique pathway for sustained neurotrophin signaling through an ankyrin-rich membrane-spanning protein.
EMBO J.
23
2358-2368
2004
197430
Chang M.-S.,Arevalo J.C.,Chao M.V.
Ternary complex with Trk, p75, and an ankyrin-rich membrane spanning protein.
J. Neurosci. Res.
78
186-192
2004
197431
Lo K.Y.,Chin W.H.,Ng Y.P.,Cheng A.W.,Cheung Z.H.,Ip N.Y.
SLAM-associated protein as a potential negative regulator in Trk signaling.
J. Biol. Chem.
280
41744-41752
2005
197432
Saxena S.,Bucci C.,Weis J.,Kruttgen A.
The small GTPase Rab7 controls the endosomal trafficking and neuritogenic signaling of the nerve growth factor receptor TrkA.
J. Neurosci.
25
10930-10940
2005
197433
Faux C.,Hawadle M.,Nixon J.,Wallace A.,Lee S.,Murray S.,Stoker A.
PTPsigma binds and dephosphorylates neurotrophin receptors and can suppress NGF-dependent neurite outgrowth from sensory neurons.
Biochim. Biophys. Acta
1773
1689-1700
2007
197434
Hisata S.,Sakisaka T.,Baba T.,Yamada T.,Aoki K.,Matsuda M.,Takai Y.
Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth.
J. Cell Biol.
178
843-860
2007
197435
Wong A.W.,Willingham M.,Xiao J.,Kilpatrick T.J.,Murray S.S.
Neurotrophin receptor homolog-2 regulates nerve growth factor signaling.
J. Neurochem.
106
1964-1976
2008
197436
Nikoletopoulou V.,Lickert H.,Frade J.M.,Rencurel C.,Giallonardo P.,Zhang L.,Bibel M.,Barde Y.A.
Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not.
Nature
467
59-63
2010
197437
Li X.,Lavigne P.,Lavoie C.
GGA3 mediates TrkA endocytic recycling to promote sustained Akt phosphorylation and cell survival.
Mol. Biol. Cell
26
4412-4426
2015
