Sequence of LYS12_YEAST
EC Number:1.1.1.87
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
homoisocitrate dehydrogenase
P40495
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
371
40069
Reaction
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD+ = 2-oxoadipate + CO2 + NADH + H+
Other sequences found for EC No. 1.1.1.87
General information:
Sequence
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>P40495|homoisocitrate dehydrogenase|EC 1.1.1.87|Saccharomyces cerevisiae (strain ATCC 204508 / S288c)|Swiss-Prot
MFRSVATRLSACRGLASNAARKSLTIGLIPGDGIGKEVIPAGKQVLENLNSKHGLSFNFI
DLYAGFQTFQETGKALPDETVKVLKEQCQGALFGAVQSPTTKVEGYSSPIVALRREMGLF
ANVRPVKSVEGEKGKPIDMVIVRENTEDLYIKIEKTYIDKATGTRVADATKRISEIATRR
IATIALDIALKRLQTRGQATLTVTHKSNVLSQSDGLFREICKEVYESNKDKYGQIKYNEQ
IVDSMVYRLFREPQCFDVIVAPNLYGDILSDGAAALVGSLGVVPSANVGPEIVIGEPCHG
SAPDIAGKGIANPIATIRSTALMLEFLGHNEAAQDIYKAVDANLREGSIKTPDLGGKAST
QQVVDDVLSRL
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
185059
Churcher C.M.,Bowman S.,Badcock K.,Bankier A.T.,Brown D.,Chillingworth T.,Connor R.,Devlin K.,Gentles S.,Hamlin N.,Harris D.E.,Horsnell T.,Hunt S.,Jagels K.,Jones M.,Lye G.,Moule S.,Odell C.,Pearson D.,Rajandream M.A.,Rice P.,Rowley N.,Skelton J.,Smith V.,Walsh S.V.,Whitehead S.,Barrell B.G.
The nucleotide sequence of Saccharomyces cerevisiae chromosome IX.
Nature
387
84-87
1997
185060
Engel S.R.,Dietrich F.S.,Fisk D.G.,Binkley G.,Balakrishnan R.,Costanzo M.C.,Dwight S.S.,Hitz B.C.,Karra K.,Nash R.S.,Weng S.,Wong E.D.,Lloyd P.,Skrzypek M.S.,Miyasato S.R.,Simison M.,Cherry J.M.
The reference genome sequence of Saccharomyces cerevisiae: Then and now.
G3 (Bethesda)
4
389-398
2014
185062
Strassman M.,Ceci L.N.
Enzymatic formation of alpha-ketoadipic acid from homoisocitric acid.
J. Biol. Chem.
240
4357-4361
1965
185063
Rowley B.,Tucci A.F.
Homoisocitric dehydrogenase from yeast.
Arch. Biochem. Biophys.
141
499-510
1970
185064
Urrestarazu L.A.,Borell C.W.,Bhattacharjee J.K.
General and specific controls of lysine biosynthesis in Saccharomyces cerevisiae.
Curr. Genet.
9
341-344
1985
185065
Shevchenko A.,Jensen O.N.,Podtelejnikov A.V.,Sagliocco F.,Wilm M.,Vorm O.,Mortensen P.,Shevchenko A.,Boucherie H.,Mann M.
Linking genome and proteome by mass spectrometry: large-scale identification of yeast proteins from two dimensional gels.
Proc. Natl. Acad. Sci. U.S.A.
93
14440-14445
1996
185066
Huh W.-K.,Falvo J.V.,Gerke L.C.,Carroll A.S.,Howson R.W.,Weissman J.S.,O'Shea E.K.
Global analysis of protein localization in budding yeast.
Nature
425
686-691
2003
185067
Ghaemmaghami S.,Huh W.-K.,Bower K.,Howson R.W.,Belle A.,Dephoure N.,O'Shea E.K.,Weissman J.S.
Global analysis of protein expression in yeast.
Nature
425
737-741
2003
185068
Sickmann A.,Reinders J.,Wagner Y.,Joppich C.,Zahedi R.P.,Meyer H.E.,Schoenfisch B.,Perschil I.,Chacinska A.,Guiard B.,Rehling P.,Pfanner N.,Meisinger C.
The proteome of Saccharomyces cerevisiae mitochondria.
Proc. Natl. Acad. Sci. U.S.A.
100
13207-13212
2003
185069
Lin Y.,Alguindigue S.S.,Volkman J.,Nicholas K.M.,West A.H.,Cook P.F.
Complete kinetic mechanism of homoisocitrate dehydrogenase from Saccharomyces cerevisiae.
Biochemistry
46
890-898
2007
185070
Albuquerque C.P.,Smolka M.B.,Payne S.H.,Bafna V.,Eng J.,Zhou H.
A multidimensional chromatography technology for in-depth phosphoproteome analysis.
Mol. Cell. Proteomics
7
1389-1396
2008
185071
Lin Y.,West A.H.,Cook P.F.
Site-directed mutagenesis as a probe of the acid-base catalytic mechanism of homoisocitrate dehydrogenase from Saccharomyces cerevisiae.
Biochemistry
48
7305-7312
2009
