Sequence of LX15B_HUMAN

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
arachidonate 15-lipoxygenase
O15296
Homo sapiens
676
75857
Reaction
arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate
Sequences with same EC No.
Sequence
show sequence in fasta format
  0 MAEFRVRVST GEAFGAGTWD KVSVSIVGTR GESPPLPLDN LGKEFTAGAE EDFQVTLPED
 60 VGRVLLLRVH KAPPVLPLLG PLAPDAWFCR WFQLTPPRGG HLLFPCYQWL EGAGTLVLQE
120 GTAKVSWADH HPVLQQQRQE ELQARQEMYQ WKAYNPGWPH CLDEKTVEDL ELNIKYSTAK
180 NANFYLQAGS AFAEMKIKGL LDRKGLWRSL NEMKRIFNFR RTPAAEHAFE HWQEDAFFAS
240 QFLNGLNPVL IRRCHYLPKN FPVTDAMVAS VLGPGTSLQA ELEKGSLFLV DHGILSGIQT
300 NVINGKPQFS AAPMTLLYQS PGCGPLLPLA IQLSQTPGPN SPIFLPTDDK WDWLLAKTWV
360 RNAEFSFHEA LTHLLHSHLL PEVFTLATLR QLPHCHPLFK LLIPHTRYTL HINTLARELL
420 IVPGQVVDRS TGIGIEGFSE LIQRNMKQLN YSLLCLPEDI RTRGVEDIPG YYYRDDGMQI
480 WGAVERFVSE IIGIYYPSDE SVQDDRELQA WVREIFSKGF LNQESSGIPS SLETREALVQ
540 YVTMVIFTCS AKHAAVSAGQ FDSCAWMPNL PPSMQLPPPT SKGLATCEGF IATLPPVNAT
600 CDVILALWLL SKEPGDQRPL GTYPDEHFTE EAPRRSIATF QSRLAQISRG IQERNQGLVL
660 PYTYLDPPLI ENSVSI
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
179086
Brash A.R.,Boeglin W.E.,Chang M.S.
Discovery of a second 15S-lipoxygenase in humans.
Proc. Natl. Acad. Sci. U.S.A.
94
6148-6152
1997
179087
Krieg P.,Marks F.,Fuerstenberger G.
A gene cluster encoding human epidermis-type lipoxygenases at chromosome 17p13.1: cloning, physical mapping, and expression.
Genomics
73
323-330
2001
179088
Tang S.,Bhatia B.,Maldonado C.J.,Yang P.,Newman R.A.,Liu J.,Chandra D.,Traag J.,Klein R.D.,Fischer S.M.,Chopra D.,Shen J.,Zhau H.E.,Chung L.W.K.,Tang D.G.
Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells.
J. Biol. Chem.
277
16189-16201
2002
179089
Zody M.C.,Garber M.,Adams D.J.,Sharpe T.,Harrow J.,Lupski J.R.,Nicholson C.,Searle S.M.,Wilming L.,Young S.K.,Abouelleil A.,Allen N.R.,Bi W.,Bloom T.,Borowsky M.L.,Bugalter B.E.,Butler J.,Chang J.L.,Chen C.-K.,Cook A.,Corum B.,Cuomo C.A.,de Jong P.J.,DeCaprio D.,Dewar K.,FitzGerald M.,Gilbert J.,Gibson R.,Gnerre S.,Goldstein S.,Grafham D.V.,Grocock R.,Hafez N.,Hagopian D.S.,Hart E.,Norman C.H.,Humphray S.,Jaffe D.B.,Jones M.,Kamal M.,Khodiyar V.K.,LaButti K.,Laird G.,Lehoczky J.,Liu X.,Lokyitsang T.,Loveland J.,Lui A.,Macdonald P.,Major J.E.,Matthews L.,Mauceli E.,McCarroll S.A.,Mihalev A.H.,Mudge J.,Nguyen C.,Nicol R.,O'Leary S.B.,Osoegawa K.,Schwartz D.C.,Shaw-Smith C.,Stankiewicz P.,Steward C.,Swarbreck D.,Venkataraman V.,Whittaker C.A.,Yang X.,Zimmer A.R.,Bradley A.,Hubbard T.,Birren B.W.,Rogers J.,Lander E.S.,Nusbaum C.
DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
Nature
440
1045-1049
2006
179091
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
179092
Kilty I.,Logan A.,Vickers P.J.
Differential characteristics of human 15-lipoxygenase isozymes and a novel splice variant of 15S-lipoxygenase.
Eur. J. Biochem.
266
83-93
1999
179093
Jisaka M.,Kim R.B.,Boeglin W.E.,Brash A.R.
Identification of amino acid determinants of the positional specificity of mouse 8S-lipoxygenase and human 15S-lipoxygenase-2.
J. Biol. Chem.
275
1287-1293
2000
179094
Bhatia B.,Maldonado C.J.,Tang S.,Chandra D.,Klein R.D.,Chopra D.,Shappell S.B.,Yang P.,Newman R.A.,Tang D.G.
Subcellular localization and tumor-suppressive functions of 15-lipoxygenase 2 (15-LOX2) and its splice variants.
J. Biol. Chem.
278
25091-25100
2003
179095
Jisaka M.,Iwanaga C.,Takahashi N.,Goto T.,Kawada T.,Yamamoto T.,Ikeda I.,Nishimura K.,Nagaya T.,Fushiki T.,Yokota K.
Double dioxygenation by mouse 8S-lipoxygenase: specific formation of a potent peroxisome proliferator-activated receptor alpha agonist.
Biochem. Biophys. Res. Commun.
338
136-143
2005
179096
Danielsson K.N.,Rydberg E.K.,Ingelsten M.,Akyuerek L.M.,Jirholt P.,Ullstroem C.,Forsberg G.B.,Boren J.,Wiklund O.,Hulten L.M.
15-Lipoxygenase-2 expression in human macrophages induces chemokine secretion and T cell migration.
Atherosclerosis
199
34-40
2008
179097
Yoo H.,Jeon B.,Jeon M.S.,Lee H.,Kim T.Y.
Reciprocal regulation of 12- and 15-lipoxygenases by UV-irradiation in human keratinocytes.
FEBS Lett.
582
3249-3253
2008
179098
Magnusson L.U.,Lundqvist A.,Karlsson M.N.,Skalen K.,Levin M.,Wiklund O.,Boren J.,Hulten L.M.
Arachidonate 15-lipoxygenase type B knockdown leads to reduced lipid accumulation and inflammation in atherosclerosis.
PLoS ONE
7
0-0
2012
179099
Kobe M.J.,Neau D.B.,Mitchell C.E.,Bartlett S.G.,Newcomer M.E.
The structure of human 15-lipoxygenase-2 with a substrate mimic.
J. Biol. Chem.
289
8562-8569
2014