Sequence of JAK2_MOUSE
EC Number:2.7.10.2
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Other sequences found for EC No. 2.7.10.2
General information:
Sequence
0 MGMACLTMTE MEATSTSPVH QNGDIPGSAN SVKQIEPVLQ VYLYHSLGQA EGEYLKFPSG
60 EYVAEEICVA ASKACGITPV YHNMFALMSE TERIWYPPNH VFHIDESTRH DILYRIRFYF
120 PHWYCSGSSR TYRYGVSRGA EAPLLDDFVM SYLFAQWRHD FVHGWIKVPV THETQEECLG
180 MAVLDMMRIA KEKDQTPLAV YNSVSYKTFL PKCVRAKIQD YHILTRKRIR YRFRRFIQQF
240 SQCKATARNL KLKYLINLET LQSAFYTEQF EVKESARGPS GEEIFATIII TGNGGIQWSR
300 GKHKESETLT EQDVQLYCDF PDIIDVSIKQ ANQECSNESR IVTVHKQDGK VLEIELSSLK
360 EALSFVSLID GYYRLTADAH HYLCKEVAPP AVLENIHSNC HGPISMDFAI SKLKKAGNQT
420 GLYVLRCSPK DFNKYFLTFA VERENVIEYK HCLITKNENG EYNLSGTKRN FSNLKDLLNC
480 YQMETVRSDS IIFQFTKCCP PKPKDKSNLL VFRTNGISDV QISPTLQRHN NVNQMVFHKI
540 RNEDLIFNES LGQGTFTKIF KGVRREVGDY GQLHKTEVLL KVLDKAHRNY SESFFEAASM
600 MSQLSHKHLV LNYGVCVCGE ENILVQEFVK FGSLDTYLKK NKNSINILWK LGVAKQLAWA
660 MHFLEEKSLI HGNVCAKNIL LIREEDRRTG NPPFIKLSDP GISITVLPKD ILQERIPWVP
720 PECIENPKNL NLATDKWSFG TTLWEICSGG DKPLSALDSQ RKLQFYEDKH QLPAPKWTEL
780 ANLINNCMDY EPDFRPAFRA VIRDLNSLFT PDYELLTEND MLPNMRIGAL GFSGAFEDRD
840 PTQFEERHLK FLQQLGKGNF GSVEMCRYDP LQDNTGEVVA VKKLQHSTEE HLRDFEREIE
900 ILKSLQHDNI VKYKGVCYSA GRRNLRLIME YLPYGSLRDY LQKHKERIDH KKLLQYTSQI
960 CKGMEYLGTK RYIHRDLATR NILVENENRV KIGDFGLTKV LPQDKEYYKV KEPGESPIFW
1020 YAPESLTESK FSVASDVWSF GVVLYELFTY IEKSKSPPVE FMRMIGNDKQ GQMIVFHLIE
1080 LLKSNGRLPR PEGCPDEIYV IMTECWNNNV SQRPSFRDLS LRVDQIRDSI AA
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
178265
Silvennoinen O.,Witthuhn B.A.,Quelle F.W.,Cleveland J.L.,Yi T.,Ihle J.N.
Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction.
Proc. Natl. Acad. Sci. U.S.A.
90
8429-8433
1993
178266
Church D.M.,Goodstadt L.,Hillier L.W.,Zody M.C.,Goldstein S.,She X.,Bult C.J.,Agarwala R.,Cherry J.L.,DiCuccio M.,Hlavina W.,Kapustin Y.,Meric P.,Maglott D.,Birtle Z.,Marques A.C.,Graves T.,Zhou S.,Teague B.,Potamousis K.,Churas C.,Place M.,Herschleb J.,Runnheim R.,Forrest D.,Amos-Landgraf J.,Schwartz D.C.,Cheng Z.,Lindblad-Toh K.,Eichler E.E.,Ponting C.P.
Lineage-specific biology revealed by a finished genome assembly of the mouse.
PLoS Biol.
7
0-0
2009
178267
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
178268
Wilks A.F.,Kurban R.R.,Hovens C.M.,Ralph S.J.
The application of the polymerase chain reaction to cloning members of the protein tyrosine kinase family.
Gene
85
67-74
1989
178269
Wilks A.F.
Two putative protein-tyrosine kinases identified by application of the polymerase chain reaction.
Proc. Natl. Acad. Sci. U.S.A.
86
1603-1607
1989
178270
Witthuhn B.A.,Quelle F.W.,Silvennoinen O.,Yi T.,Tang B.,Miura O.,Ihle J.N.
JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin.
Cell
74
227-236
1993
178271
Zhao Y.,Wagner F.,Frank S.J.,Kraft A.S.
The amino-terminal portion of the JAK2 protein kinase is necessary for binding and phosphorylation of the granulocyte-macrophage colony-stimulating factor receptor beta c chain.
J. Biol. Chem.
270
13814-13818
1995
178272
Nakamura N.,Chin H.,Miyasaka N.,Miura O.
An epidermal growth factor receptor/Jak2 tyrosine kinase domain chimera induces tyrosine phosphorylation of Stat5 and transduces a growth signal in hematopoietic cells.
J. Biol. Chem.
271
19483-19488
1996
178273
Yamashita Y.,Watanabe S.,Miyazato A.,Ohya K.,Ikeda U.,Shimada K.,Komatsu N.,Hatake K.,Miura Y.,Ozawa K.,Mano H.
Tec and Jak2 kinases cooperate to mediate cytokine-driven activation of c-fos transcription.
Blood
91
1496-1507
1998
178274
Chin H.,Arai A.,Wakao H.,Kamiyama R.,Miyasaka N.,Miura O.
Lyn physically associates with the erythropoietin receptor and may play a role in activation of the Stat5 pathway.
Blood
91
3734-3745
1998
178275
Parganas E.,Wang D.,Stravopodis D.,Topham D.J.,Marine J.C.,Teglund S.,Vanin E.F.,Bodner S.,Colamonici O.R.,van Deursen J.M.,Grosveld G.,Ihle J.N.
Jak2 is essential for signaling through a variety of cytokine receptors.
Cell
93
385-395
1998
178276
Neubauer H.,Cumano A.,Muller M.,Wu H.,Huffstadt U.,Pfeffer K.
Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis.
Cell
93
397-409
1998
178277
Trost M.,English L.,Lemieux S.,Courcelles M.,Desjardins M.,Thibault P.
The phagosomal proteome in interferon-gamma-activated macrophages.
Immunity
30
143-154
2009
178278
Huttlin E.L.,Jedrychowski M.P.,Elias J.E.,Goswami T.,Rad R.,Beausoleil S.A.,Villen J.,Haas W.,Sowa M.E.,Gygi S.P.
A tissue-specific atlas of mouse protein phosphorylation and expression.
Cell
143
1174-1189
2010
178279
Guilluy C.,Bregeon J.,Toumaniantz G.,Rolli-Derkinderen M.,Retailleau K.,Loufrani L.,Henrion D.,Scalbert E.,Bril A.,Torres R.M.,Offermanns S.,Pacaud P.,Loirand G.
The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure.
Nat. Med.
16
183-190
2010
178280
Stofega M.R.,Argetsinger L.S.,Wang H.,Ullrich A.,Carter-Su C.
Negative regulation of growth hormone receptor/JAK2 signaling by signal regulatory protein alpha.
J. Biol. Chem.
275
28222-28229
2000
178281
Huang L.J.,Constantinescu S.N.,Lodish H.F.
The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor.
Mol. Cell
8
1327-1338
2001
178282
Bahrenberg G.,Behrmann I.,Barthel A.,Hekerman P.,Heinrich P.C.,Joost H.G.,Becker W.
Identification of the critical sequence elements in the cytoplasmic domain of leptin receptor isoforms required for Janus kinase/signal transducer and activator of transcription activation by receptor heterodimers.
Mol. Endocrinol.
16
859-872
2002
178283
Funakoshi-Tago M.,Pelletier S.,Matsuda T.,Parganas E.,Ihle J.N.
Receptor specific downregulation of cytokine signaling by autophosphorylation in the FERM domain of Jak2.
EMBO J.
25
4763-4772
2006
178284
Li Z.,Zhou Y.,Carter-Su C.,Myers M.G. Jr.,Rui L.
SH2B1 enhances leptin signaling by both Janus kinase 2 Tyr813 phosphorylation-dependent and -independent mechanisms.
Mol. Endocrinol.
21
2270-2281
2007
178285
Argetsinger L.S.,Stuckey J.A.,Robertson S.A.,Koleva R.I.,Cline J.M.,Marto J.A.,Myers M.G. Jr.,Carter-Su C.
Tyrosines 868, 966, and 972 in the kinase domain of JAK2 are autophosphorylated and required for maximal JAK2 kinase activity.
Mol. Endocrinol.
24
1062-1076
2010
178286
Sayyah J.,Gnanasambandan K.,Kamarajugudda S.,Tsuda S.,Caldwell-Busby J.,Sayeski P.P.
Phosphorylation of Y372 is critical for Jak2 tyrosine kinase activation.
Cell. Signal.
23
1806-1815
2011
178287
Berry D.C.,Jin H.,Majumdar A.,Noy N.
Signaling by vitamin A and retinol-binding protein regulates gene expression to inhibit insulin responses.
Proc. Natl. Acad. Sci. U.S.A.
108
4340-4345
2011
178288
Jakel H.,Weinl C.,Hengst L.
Phosphorylation of p27Kip1 by JAK2 directly links cytokine receptor signaling to cell cycle control.
Oncogene
30
3502-3512
2011
178289
Ihle J.N.,Gilliland D.G.
Jak2: normal function and role in hematopoietic disorders.
Curr. Opin. Genet. Dev.
17
8-14
2007
178290
Hu J.,Hubbard S.R.
Structural basis for phosphotyrosine recognition by the Src homology-2 domains of the adapter proteins SH2-B and APS.
J. Mol. Biol.
361
69-79
2006
