Sequence of HMDH1_YEAST
EC Number:1.1.1.34
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
hydroxymethylglutaryl-CoA reductase (NADPH)
P12683
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
1054
115626
Reaction
(R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
Other sequences found for EC No. 1.1.1.34
General information:
Sequence
0 MPPLFKGLKQ MAKPIAYVSR FSAKRPIHII LFSLIISAFA YLSVIQYYFN GWQLDSNSVF
60 ETAPNKDSNT LFQECSHYYR DSSLDGWVSI TAHEASELPA PHHYYLLNLN FNSPNETDSI
120 PELANTVFEK DNTKYILQED LSVSKEISST DGTKWRLRSD RKSLFDVKTL AYSLYDVFSE
180 NVTQADPFDV LIMVTAYLMM FYTIFGLFND MRKTGSNFWL SASTVVNSAS SLFLALYVTQ
240 CILGKEVSAL TLFEGLPFIV VVVGFKHKIK IAQYALEKFE RVGLSKRITT DEIVFESVSE
300 EGGRLIQDHL LCIFAFIGCS MYAHQLKTLT NFCILSAFIL IFELILTPTF YSAILALRLE
360 MNVIHRSTII KQTLEEDGVV PSTARIISKA EKKSVSSFLN LSVVVIIMKL SVILLFVFIN
420 FYNFGANWVN DAFNSLYFDK ERVSLPDFIT SNASENFKEQ AIVSVTPLLY YKPIKSYQRI
480 EDMVLLLLRN VSVAIRDRFV SKLVLSALVC SAVINVYLLN AARIHTSYTA DQLVKTEVTK
540 KSFTAPVQKA STPVLTNKTV ISGSKVKSLS SAQSSSSGPS SSSEEDDSRD IESLDKKIRP
600 LEELEALLSS GNTKQLKNKE VAALVIHGKL PLYALEKKLG DTTRAVAVRR KALSILAEAP
660 VLASDRLPYK NYDYDRVFGA CCENVIGYMP LPVGVIGPLV IDGTSYHIPM ATTEGCLVAS
720 AMRGCKAINA GGGATTVLTK DGMTRGPVVR FPTLKRSGAC KIWLDSEEGQ NAIKKAFNST
780 SRFARLQHIQ TCLAGDLLFM RFRTTTGDAM GMNMISKGVE YSLKQMVEEY GWEDMEVVSV
840 SGNYCTDKKP AAINWIEGRG KSVVAEATIP GDVVRKVLKS DVSALVELNI AKNLVGSAMA
900 GSVGGFNAHA ANLVTAVFLA LGQDPAQNVE SSNCITLMKE VDGDLRISVS MPSIEVGTIG
960 GGTVLEPQGA MLDLLGVRGP HATAPGTNAR QLARIVACAV LAGELSLCAA LAAGHLVQSH
1020 MTHNRKPAEP TKPNNLDATD INRLKDGSVT CIKS
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
172528
Basson M.E.,Thorsness M.,Finer-Moore J.,Stroud R.M.,Rine J.
Structural and functional conservation between yeast and human 3-hydroxy-3-methylglutaryl coenzyme A reductases, the rate-limiting enzyme of sterol biosynthesis.
Mol. Cell. Biol.
8
3797-3808
1988
172529
Bowman S.,Churcher C.M.,Badcock K.,Brown D.,Chillingworth T.,Connor R.,Dedman K.,Devlin K.,Gentles S.,Hamlin N.,Hunt S.,Jagels K.,Lye G.,Moule S.,Odell C.,Pearson D.,Rajandream M.A.,Rice P.,Skelton J.,Walsh S.V.,Whitehead S.,Barrell B.G.
The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.
Nature
387
90-93
1997
172530
Engel S.R.,Dietrich F.S.,Fisk D.G.,Binkley G.,Balakrishnan R.,Costanzo M.C.,Dwight S.S.,Hitz B.C.,Karra K.,Nash R.S.,Weng S.,Wong E.D.,Lloyd P.,Skrzypek M.S.,Miyasato S.R.,Simison M.,Cherry J.M.
The reference genome sequence of Saccharomyces cerevisiae: Then and now.
G3 (Bethesda)
4
389-398
2014
172531
Basson M.E.,Thorsness M.,Rine J.
Saccharomyces cerevisiae contains two functional genes encoding 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
Proc. Natl. Acad. Sci. U.S.A.
83
5563-5567
1986
172532
Koning A.J.,Roberts C.J.,Wright R.L.
Different subcellular localization of Saccharomyces cerevisiae HMG-CoA reductase isozymes at elevated levels corresponds to distinct endoplasmic reticulum membrane proliferations.
Mol. Biol. Cell
7
769-789
1996
172533
Huh W.-K.,Falvo J.V.,Gerke L.C.,Carroll A.S.,Howson R.W.,Weissman J.S.,O'Shea E.K.
Global analysis of protein localization in budding yeast.
Nature
425
686-691
2003
172534
Li X.,Gerber S.A.,Rudner A.D.,Beausoleil S.A.,Haas W.,Villen J.,Elias J.E.,Gygi S.P.
Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.
J. Proteome Res.
6
1190-1197
2007
172535
Holt L.J.,Tuch B.B.,Villen J.,Johnson A.D.,Gygi S.P.,Morgan D.O.
Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.
Science
325
1682-1686
2009
172536
Jorda T.,Puig S.
Regulation of ergosterol biosynthesis in Saccharomyces cerevisiae.
Genes (Basel)
11
0-0
2020
