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Sequence of ACVR1_HUMAN

EC Number:2.7.10.2

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
2.7.10.2
non-specific protein-tyrosine kinase
Q04771
Homo sapiens
509
57153
Swiss-Prot
Reaction
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Other sequences found for EC No. 2.7.10.2

General information:

Sequence
show sequence in fasta format
  0 MVDGVMILPV LIMIALPSPS MEDEKPKVNP KLYMCVCEGL SCGNEDHCEG QQCFSSLSIN
 60 DGFHVYQKGC FQVYEQGKMT CKTPPSPGQA VECCQGDWCN RNITAQLPTK GKSFPGTQNF
120 HLEVGLIILS VVFAVCLLAC LLGVALRKFK RRNQERLNPR DVEYGTIEGL ITTNVGDSTL
180 ADLLDHSCTS GSGSGLPFLV QRTVARQITL LECVGKGRYG EVWRGSWQGE NVAVKIFSSR
240 DEKSWFRETE LYNTVMLRHE NILGFIASDM TSRHSSTQLW LITHYHEMGS LYDYLQLTTL
300 DTVSCLRIVL SIASGLAHLH IEIFGTQGKP AIAHRDLKSK NILVKKNGQC CIADLGLAVM
360 HSQSTNQLDV GNNPRVGTKR YMAPEVLDET IQVDCFDSYK RVDIWAFGLV LWEVARRMVS
420 NGIVEDYKPP FYDVVPNDPS FEDMRKVVCV DQQRPNIPNR WFSDPTLTSL AKLMKECWYQ
480 NPSARLTALR IKKTLTKIDN SLDKLKTDC
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1154101
Matsuzaki K.,McKeehan W.L.
A widely expressed transmembrane serine/threonine kinase that does not bind activin, inhibin, transforming growth factor beta, or bone morphogenic factor.
J. Biol. Chem.
268
12719-12723
1993
8389764
1154102
ten Dijke P.,Ichijo H.,Franzen P.,Schulz P.,Saras J.,Toyoshima H.,Heldin C.-H.,Miyazono K.
Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity.
Oncogene
8
2879-2887
1993
8397373
1154103
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
15489334
1154104
Reddy K.B.,Karode M.C.,Harmony A.K.,Howe P.H.
Interaction of transforming growth factor beta receptors with apolipoprotein J/clusterin.
Biochemistry
35
309-314
1996
8555189
1154105
Macias-Silva M.,Hoodless P.A.,Tang S.J.,Buchwald M.,Wrana J.L.
Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2.
J. Biol. Chem.
273
25628-25636
1998
9748228
1154106
Renlund N.,O'Neill F.H.,Zhang L.,Sidis Y.,Teixeira J.
Activin receptor-like kinase-2 inhibits activin signaling by blocking the binding of activin to its type II receptor.
J. Endocrinol.
195
95-103
2007
17911401
1154107
Saremba S.,Nickel J.,Seher A.,Kotzsch A.,Sebald W.,Mueller T.D.
Type I receptor binding of bone morphogenetic protein 6 is dependent on N-glycosylation of the ligand.
FEBS J.
275
172-183
2008
18070108
1154108
Oppermann F.S.,Gnad F.,Olsen J.V.,Hornberger R.,Greff Z.,Keri G.,Mann M.,Daub H.
Large-scale proteomics analysis of the human kinome.
Mol. Cell. Proteomics
8
1751-1764
2009
19369195
1154109
Luo J.,Tang M.,Huang J.,He B.C.,Gao J.L.,Chen L.,Zuo G.W.,Zhang W.,Luo Q.,Shi Q.,Zhang B.Q.,Bi Y.,Luo X.,Jiang W.,Su Y.,Shen J.,Kim S.H.,Huang E.,Gao Y.,Zhou J.Z.,Yang K.,Luu H.H.,Pan X.,Haydon R.C.,Deng Z.L.,He T.C.
TGFbeta/BMP type I receptors ALK1 and ALK2 are essential for BMP9-induced osteogenic signaling in mesenchymal stem cells.
J. Biol. Chem.
285
29588-29598
2010
20628059
1154110
Umasankar P.K.,Sanker S.,Thieman J.R.,Chakraborty S.,Wendland B.,Tsang M.,Traub L.M.
Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning.
Nat. Cell Biol.
14
488-501
2012
22484487
1154111
Fujimoto M.,Ohte S.,Osawa K.,Miyamoto A.,Tsukamoto S.,Mizuta T.,Kokabu S.,Suda N.,Katagiri T.
Mutant activin-like kinase 2 in fibrodysplasia ossificans progressiva are activated via T203 by BMP type II receptors.
Mol. Endocrinol.
29
140-152
2015
25354296
1154113
Chaikuad A.,Alfano I.,Kerr G.,Sanvitale C.E.,Boergermann J.H.,Triffitt J.T.,von Delft F.,Knapp S.,Knaus P.,Bullock A.N.
Structure of the bone morphogenetic protein receptor ALK2 and implications for fibrodysplasia ossificans progressiva.
J. Biol. Chem.
287
36990-36998
2012
22977237
1154114
Shore E.M.,Xu M.,Feldman G.J.,Fenstermacher D.A.,Brown M.A.,Kaplan F.S.
A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva.
Nat. Genet.
38
525-527
2006
16642017
1154115
Greenman C.,Stephens P.,Smith R.,Dalgliesh G.L.,Hunter C.,Bignell G.,Davies H.,Teague J.,Butler A.,Stevens C.,Edkins S.,O'Meara S.,Vastrik I.,Schmidt E.E.,Avis T.,Barthorpe S.,Bhamra G.,Buck G.,Choudhury B.,Clements J.,Cole J.,Dicks E.,Forbes S.,Gray K.,Halliday K.,Harrison R.,Hills K.,Hinton J.,Jenkinson A.,Jones D.,Menzies A.,Mironenko T.,Perry J.,Raine K.,Richardson D.,Shepherd R.,Small A.,Tofts C.,Varian J.,Webb T.,West S.,Widaa S.,Yates A.,Cahill D.P.,Louis D.N.,Goldstraw P.,Nicholson A.G.,Brasseur F.,Looijenga L.,Weber B.L.,Chiew Y.-E.,DeFazio A.,Greaves M.F.,Green A.R.,Campbell P.,Birney E.,Easton D.F.,Chenevix-Trench G.,Tan M.-H.,Khoo S.K.,Teh B.T.,Yuen S.T.,Leung S.Y.,Wooster R.,Futreal P.A.,Stratton M.R.
Patterns of somatic mutation in human cancer genomes.
Nature
446
153-158
2007
17344846
1154116
Kaplan F.S.,Xu M.,Seemann P.,Connor J.M.,Glaser D.L.,Carroll L.,Delai P.,Fastnacht-Urban E.,Forman S.J.,Gillessen-Kaesbach G.,Hoover-Fong J.,Koester B.,Pauli R.M.,Reardon W.,Zaidi S.A.,Zasloff M.,Morhart R.,Mundlos S.,Groppe J.,Shore E.M.
Classic and atypical fibrodysplasia ossificans progressiva (FOP) phenotypes are caused by mutations in the bone morphogenetic protein (BMP) type I receptor ACVR1.
Hum. Mutat.
30
379-390
2009
19085907
1154117
Petrie K.A.,Lee W.H.,Bullock A.N.,Pointon J.J.,Smith R.,Russell R.G.,Brown M.A.,Wordsworth B.P.,Triffitt J.T.
Novel mutations in ACVR1 result in atypical features in two fibrodysplasia ossificans progressiva patients.
PLoS ONE
4
0-0
2009
19330033