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Sequence of OST3_YEAST

EC Number:2.4.99.18

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
dolichyl-diphosphooligosaccharide-protein glycotransferase
P48439
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
350
39483
Reaction
dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine
Other sequences found for EC No. 2.4.99.18

General information:

Sequence
show sequence in fasta format
  0 MNWLFLVSLV FFCGVSTHPA LAMSSNRLLK LANKSPKKII PLKDSSFENI LAPPHENAYI
 60 VALFTATAPE IGCSLCLELE SEYDTIVASW FDDHPDAKSS NSDTSIFFTK VNLEDPSKTI
120 PKAFQFFQLN NVPRLFIFKP NSPSILDHSV ISISTDTGSE RMKQIIQAIK QFSQVNDFSL
180 HLPMDWTPII TSTIITFITV LLFKKQSKLM FSIISSRIIW ATLSTFFIIC MISAYMFNQI
240 RNTQLAGVGP KGEVMYFLPN EFQHQFAIET QVMVLIYGTL AALVVVLVKG IQFLRSHLYP
300 ETKKAYFIDA ILASFCALFI YVFFAALTTV FTIKSPAYPF PLLRLSAPFK
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
708113
Karaoglu D.,Kelleher D.J.,Gilmore R.
Functional characterization of Ost3p. Loss of the 34-kD subunit of the Saccharomyces cerevisiae oligosaccharyltransferase results in biased underglycosylation of acceptor substrates.
J. Cell Biol.
130
567-577
1995
708114
Knauer R.,Lehle L.
The oligosaccharyltransferase complex from Saccharomyces cerevisiae. Isolation of the OST6 gene, its synthetic interaction with OST3, and analysis of the native complex.
J. Biol. Chem.
274
17249-17256
1999
708115
Voss H.,Benes V.,Andrade M.A.,Valencia A.,Rechmann S.,Teodoru C.,Schwager C.,Paces V.,Sander C.,Ansorge W.
DNA sequencing and analysis of 130 kb from yeast chromosome XV.
Yeast
13
655-672
1997
708116
Dujon B.,Albermann K.,Aldea M.,Alexandraki D.,Ansorge W.,Arino J.,Benes V.,Bohn C.,Bolotin-Fukuhara M.,Bordonne R.,Boyer J.,Camasses A.,Casamayor A.,Casas C.,Cheret G.,Cziepluch C.,Daignan-Fornier B.,Dang V.-D.,de Haan M.,Delius H.,Durand P.,Fairhead C.,Feldmann H.,Gaillon L.,Galisson F.,Gamo F.-J.,Gancedo C.,Goffeau A.,Goulding S.E.,Grivell L.A.,Habbig B.,Hand N.J.,Hani J.,Hattenhorst U.,Hebling U.,Hernando Y.,Herrero E.,Heumann K.,Hiesel R.,Hilger F.,Hofmann B.,Hollenberg C.P.,Hughes B.,Jauniaux J.-C.,Kalogeropoulos A.,Katsoulou C.,Kordes E.,Lafuente M.J.,Landt O.,Louis E.J.,Maarse A.C.,Madania A.,Mannhaupt G.,Marck C.,Martin R.P.,Mewes H.-W.,Michaux G.,Paces V.,Parle-McDermott A.G.,Pearson B.M.,Perrin A.,Pettersson B.,Poch O.,Pohl T.M.,Poirey R.,Portetelle D.,Pujol A.,Purnelle B.,Ramezani Rad M.,Rechmann S.,Schwager C.,Schweizer M.,Sor F.,Sterky F.,Tarassov I.A.,Teodoru C.,Tettelin H.,Thierry A.,Tobiasch E.,Tzermia M.,Uhlen M.,Unseld M.,Valens M.,Vandenbol M.,Vetter I.,Vlcek C.,Voet M.,Volckaert G.,Voss H.,Wambutt R.,Wedler H.,Wiemann S.,Winsor B.,Wolfe K.H.,Zollner A.,Zumstein E.,Kleine K.
The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.
Nature
387
98-102
1997
708117
Engel S.R.,Dietrich F.S.,Fisk D.G.,Binkley G.,Balakrishnan R.,Costanzo M.C.,Dwight S.S.,Hitz B.C.,Karra K.,Nash R.S.,Weng S.,Wong E.D.,Lloyd P.,Skrzypek M.S.,Miyasato S.R.,Simison M.,Cherry J.M.
The reference genome sequence of Saccharomyces cerevisiae: Then and now.
G3 (Bethesda)
4
389-398
2014
708118
Hu Y.,Rolfs A.,Bhullar B.,Murthy T.V.S.,Zhu C.,Berger M.F.,Camargo A.A.,Kelley F.,McCarron S.,Jepson D.,Richardson A.,Raphael J.,Moreira D.,Taycher E.,Zuo D.,Mohr S.,Kane M.F.,Williamson J.,Simpson A.J.G.,Bulyk M.L.,Harlow E.,Marsischky G.,Kolodner R.D.,LaBaer J.
Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.
Genome Res.
17
536-543
2007
708119
Kelleher D.J.,Gilmore R.
The Saccharomyces cerevisiae oligosaccharyltransferase is a protein complex composed of Wbp1p, Swp1p, and four additional polypeptides.
J. Biol. Chem.
269
12908-12917
1994
708120
Karaoglu D.,Kelleher D.J.,Gilmore R.
The highly conserved Stt3 protein is a subunit of the yeast oligosaccharyltransferase and forms a subcomplex with Ost3p and Ost4p.
J. Biol. Chem.
272
32513-32520
1997
708121
Knauer R.,Lehle L.
The oligosaccharyltransferase complex from yeast.
Biochim. Biophys. Acta
1426
259-273
1999
708122
Kim H.,Park H.,Montalvo L.,Lennarz W.J.
Studies on the role of the hydrophobic domain of Ost4p in interactions with other subunits of yeast oligosaccharyl transferase.
Proc. Natl. Acad. Sci. U.S.A.
97
1516-1520
2000
708123
Karaoglu D.,Kelleher D.J.,Gilmore R.
Allosteric regulation provides a molecular mechanism for preferential utilization of the fully assembled dolichol-linked oligosaccharide by the yeast oligosaccharyltransferase.
Biochemistry
40
12193-12206
2001
708124
Ghaemmaghami S.,Huh W.-K.,Bower K.,Howson R.W.,Belle A.,Dephoure N.,O'Shea E.K.,Weissman J.S.
Global analysis of protein expression in yeast.
Nature
425
737-741
2003
708125
Schwarz M.,Knauer R.,Lehle L.
Yeast oligosaccharyltransferase consists of two functionally distinct sub-complexes, specified by either the Ost3p or Ost6p subunit.
FEBS Lett.
579
6564-6568
2005
708126
Spirig U.,Bodmer D.,Wacker M.,Burda P.,Aebi M.
The 3.4-kDa Ost4 protein is required for the assembly of two distinct oligosaccharyltransferase complexes in yeast.
Glycobiology
15
1396-1406
2005
708127
Yan A.,Lennarz W.J.
Two oligosaccharyl transferase complexes exist in yeast and associate with two different translocons.
Glycobiology
15
1407-1415
2005
708128
Yan A.,Wu E.,Lennarz W.J.
Studies of yeast oligosaccharyl transferase subunits using the split-ubiquitin system: topological features and in vivo interactions.
Proc. Natl. Acad. Sci. U.S.A.
102
7121-7126
2005
708129
Bai L.,Wang T.,Zhao G.,Kovach A.,Li H.
The atomic structure of a eukaryotic oligosaccharyltransferase complex.
Nature
555
328-333
2018
708130
Wild R.,Kowal J.,Eyring J.,Ngwa E.M.,Aebi M.,Locher K.P.
Structure of the yeast oligosaccharyltransferase complex gives insight into eukaryotic N-glycosylation.
Science
359
545-550
2018