Sequence of PCSK4_MOUSE
EC Number:3.4.21.B24
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
cleaves hormones at pairs of basic amino acid residues
Other sequences found for EC No. 3.4.21.B24
General information:
Sequence
0 MRPSQTELWL GLTLTLALLA VRWASAQAPI YVSSWAVRVT KGYQEAERLA RKFGFVNLGQ
60 IFPDDQYFHL RHRGVAQQSL TPHWGHRLRL KKDPKVRWFE QQTLRRRVKR SLVVPTDPWF
120 SKQWYMNKEI QQDLNILKAW NQGLTGRGVV ISILDDGIEK DHPDLWANYD PLASYDFNDY
180 DPDPQPRYTP NDENRHGTRC AGEVSATANN GFCGAGVAFN ARIGGVRMLD GAITDIVEAQ
240 SLSLQPQHIH IYSASWGPED DGRTVDGPGL LTQEAFRRGV TKGRQGLGTL FIWASGNGGL
300 HYDNCNCDGY TNSIHTLSVG STTRQGRVPW YSEACASTFT TTFSSGVVTD PQIVTTDLHH
360 QCTDKHTGTS ASAPLAAGMI ALALEANPLL TWRDLQHLVV RASRPAQLQA EDWRINGVGR
420 QVSHHYGYGL LDAGLLVDLA RVWLPTKPQK KCAIRVVHTP TPILPRMLVP KNVTACSDGS
480 RRRLIRSLEH VQVQLSLSYS RRGDLEIFLT SPMGTRSTLV AIRPLDISGQ GYNNWIFMST
540 HYWDEDPQGL WTLGLENKGY YFNTGTLYYY TLLLYGTAED MTARPQAPQV TSRARACVQR
600 DTEGLCQESH SPLSILAGLC LISSQQWWWL YSHPQQPVTE GQASCHPPVT PAAAA
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
331598
Nakayama K.,Kim W.-S.,Torii S.,Hosaka M.,Nakagawa T.,Ikemizu J.,Baba T.,Murakami K.
Identification of the fourth member of the mammalian endoprotease family homologous to the yeast Kex2 protease. Its testis-specific expression.
J. Biol. Chem.
267
5897-5900
1992
331599
Seidah N.G.,Day R.,Hamelin J.,Gaspar A.,Collard M.W.,Chretien M.
Testicular expression of PC4 in the rat: molecular diversity of a novel germ cell-specific Kex2/subtilisin-like proprotein convertase.
Mol. Endocrinol.
6
1559-1570
1992
331600
Mbikay M.,Raffin-Sanson M.-L.,Tadros H.,Sirois F.,Seidah N.G.,Chretien M.
Structure of the gene for the testis-specific proprotein convertase 4 and of its alternate messenger RNA isoforms.
Genomics
20
231-237
1994
331601
Mbikay M.,Tadros H.,Ishida N.,Lerner C.P.,De Lamirande E.,Chen A.,El-Alfy M.,Clermont Y.,Seidah N.G.,Chretien M.,Gagnon C.,Simpson E.M.
Impaired fertility in mice deficient for the testicular germ-cell protease PC4.
Proc. Natl. Acad. Sci. U.S.A.
94
6842-6846
1997
331602
Tadros H.,Chretien M.,Mbikay M.
The testicular germ-cell protease PC4 is also expressed in macrophage-like cells of the ovary.
J. Reprod. Immunol.
49
133-152
2001
331603
Gyamera-Acheampong C.,Tantibhedhyangkul J.,Weerachatyanukul W.,Tadros H.,Xu H.,van de Loo J.W.,Pelletier R.M.,Tanphaichitr N.,Mbikay M.
Sperm from mice genetically deficient for the PCSK4 proteinase exhibit accelerated capacitation, precocious acrosome reaction, reduced binding to egg zona pellucida, and impaired fertilizing ability.
Biol. Reprod.
74
666-673
2006
331604
Gyamera-Acheampong C.,Vasilescu J.,Figeys D.,Mbikay M.
PCSK4-null sperm display enhanced protein tyrosine phosphorylation and ADAM2 proteolytic processing during in vitro capacitation.
Fertil. Steril.
93
1112-1123
2010
331605
Iamsaard S.,Vanichviriyakit R.,Hommalai G.,Saewu A.,Srakaew N.,Withyachumnarnkul B.,Basak A.,Tanphaichitr N.
Enzymatic activity of sperm proprotein convertase is important for mammalian fertilization.
J. Cell. Physiol.
226
2817-2826
2011
331606
Gyamera-Acheampong C.,Sirois F.,Denis N.J.,Mishra P.,Figeys D.,Basak A.,Mbikay M.
The precursor to the germ cell-specific PCSK4 proteinase is inefficiently activated in transfected somatic cells: evidence of interaction with the BiP chaperone.
Mol. Cell. Biochem.
348
43-52
2011
331607
Tardif S.,Guyonnet B.,Cormier N.,Cornwall G.A.
Alteration in the processing of the ACRBP/sp32 protein and sperm head/acrosome malformations in proprotein convertase 4 (PCSK4) null mice.
Mol. Hum. Reprod.
18
298-307
2012
