Sequence of ALDH1_ARTAN
EC Number:1.14.14.114
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
amorpha-4,11-diene + 3 O2 + 3 [reduced NADPH-hemoprotein reductase] = artemisinate + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
Other sequences found for EC No. 1.14.14.114
General information:
Sequence
0 MSSGANGSSK SASHKIKFTK LFINGEFVDS ISGNTFDTIN PATEEVLATV AEGRKEDIDL
60 AVKAAREAFD NGPWPRMSGE ARRKIMLKFA DLIDENADEL TTLEVIDGGK LFGPVRHFEV
120 PVSSDTFRYF AGAADKIRGA TLKMSSNIQA YTLREPIGVV GHIIPWNGPA FMFATKVAPA
180 LAAGCTMVIK PAEHTPLTVL FLAHLSKLAG VPDGVINVVN GFGKTAGAAV SSHMDIDMVT
240 FTGSTEVGRT VMQAAALSNL KPVSLELGGK SPLIVFDDAD VDKAAEFAIL GNFTNKGEMC
300 VAGSRVFVQE GIHDVFVKKL EGAVKAWATR DPFDLATRHG PQNNKQQYDK VLSCINHGKK
360 EGATLVTGGK PFGKKGYYIE PTLFTNVTDD MTIAKEEIFG PVISVLKFKT VEEVIKRANA
420 TKYGLASGVF TKNIDVVNTV SRSIRAGAVW VNCYLALDRD APHGGYKMSG FGREQGLEAL
480 EHYLQIKTVA TPIYDSPWL
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
3787
Shen Q.,Zhang L.,Liao Z.,Wang S.,Yan T.,Shi P.,Liu M.,Fu X.,Pan Q.,Wang Y.,Lv Z.,Lu X.,Zhang F.,Jiang W.,Ma Y.,Chen M.,Hao X.,Li L.,Tang Y.,Lv G.,Zhou Y.,Sun X.,Brodelius P.E.,Rose J.K.C.,Tang K.
The genome of Artemisia annua provides insight into the evolution of Asteraceae family and artemisinin biosynthesis.
Mol. Plant
11
776-788
2018
3788
Olofsson L.,Lundgren A.,Brodelius P.E.
Trichome isolation with and without fixation using laser microdissection and pressure catapulting followed by RNA amplification: expression of genes of terpene metabolism in apical and sub-apical trichome cells of Artemisia annua L.
Plant Sci.
183
9-13
2012
3789
Paddon C.J.,Westfall P.J.,Pitera D.J.,Benjamin K.,Fisher K.,McPhee D.,Leavell M.D.,Tai A.,Main A.,Eng D.,Polichuk D.R.,Teoh K.H.,Reed D.W.,Treynor T.,Lenihan J.,Fleck M.,Bajad S.,Dang G.,Diola D.,Dorin G.,Ellens K.W.,Fickes S.,Galazzo J.,Gaucher S.P.,Geistlinger T.,Henry R.,Hepp M.,Horning T.,Iqbal T.,Jiang H.,Kizer L.,Lieu B.,Melis D.,Moss N.,Regentin R.,Secrest S.,Tsuruta H.,Vazquez R.,Westblade L.F.,Xu L.,Yu M.,Zhang Y.,Zhao L.,Lievense J.,Covello P.S.,Keasling J.D.,Reiling K.K.,Renninger N.S.,Newman J.D.
High-level semi-synthetic production of the potent antimalarial artemisinin.
Nature
496
528-532
2013
3790
Tu Y.
Artemisinin-A Gift from Traditional Chinese Medicine to the World (Nobel Lecture).
Angew. Chem. Int. Ed.
55
10210-10226
2016
3791
Judd R.,Bagley M.C.,Li M.,Zhu Y.,Lei C.,Yuzuak S.,Ekeloef M.,Pu G.,Zhao X.,Muddiman D.C.,Xie D.-Y.
Artemisinin biosynthesis in non-glandular trichome cells of Artemisia annua.
Mol. Plant
12
704-714
2019
3792
Liu Y.,Jing S.-X.,Luo S.-H.,Li S.-H.
Non-volatile natural products in plant glandular trichomes: chemistry, biological activities and biosynthesis.
Nat. Prod. Rep.
36
626-665
2019
3793
Uzun T.,Toptas O.
Artesunate: could be an alternative drug to chloroquine in COVID-19 treatment?
Chin. Med. J.
15
54-54
2020
3794
Cheong D.H.J.,Tan D.W.S.,Wong F.W.S.,Tran T.
Anti-malarial drug, artemisinin and its derivatives for the treatment of respiratory diseases.
Pharmacol. Res.
158
104901-104901
2020
