Sequence of FA10_BOVIN
EC Number:3.4.21.6
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
selective cleavage of Arg-/-Thr and then Arg-/-Ile bonds in prothrombin to form thrombin
Other sequences found for EC No. 3.4.21.6
General information:
Sequence
0 MAGLLHLVLL STALGGLLRP AGSVFLPRDQ AHRVLQRARR ANSFLEEVKQ GNLERECLEE
60 ACSLEEAREV FEDAEQTDEF WSKYKDGDQC EGHPCLNQGH CKDGIGDYTC TCAEGFEGKN
120 CEFSTREICS LDNGGCDQFC REERSEVRCS CAHGYVLGDD SKSCVSTERF PCGKFTQGRS
180 RRWAIHTSED ALDASELEHY DPADLSPTES SLDLLGLNRT EPSAGEDGSQ VVRIVGGRDC
240 AEGECPWQAL LVNEENEGFC GGTILNEFYV LTAAHCLHQA KRFTVRVGDR NTEQEEGNEM
300 AHEVEMTVKH SRFVKETYDF DIAVLRLKTP IRFRRNVAPA CLPEKDWAEA TLMTQKTGIV
360 SGFGRTHEKG RLSSTLKMLE VPYVDRSTCK LSSSFTITPN MFCAGYDTQP EDACQGDSGG
420 PHVTRFKDTY FVTGIVSWGE GCARKGKFGV YTKVSNFLKW IDKIMKARAG AAGSRGHSEA
480 PATWTVPPPL PL
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
160076
Fung M.R.,Campbell R.M.,McGillivray R.T.A.
Blood coagulation factor X mRNA encodes a single polypeptide chain containing a prepro leader sequence.
Nucleic Acids Res.
12
4481-4492
1984
160077
Enfield D.L.,Ericsson L.H.,Fujikawa K.,Walsh K.A.,Neurath H.,Titani K.
Amino acid sequence of the light chain of bovine factor X1 (Stuart factor).
Biochemistry
19
659-667
1980
160078
McMullen B.A.,Fujikawa K.,Kisiel W.
The occurrence of beta-hydroxyaspartic acid in the vitamin K-dependent blood coagulation zymogens.
Biochem. Biophys. Res. Commun.
115
8-14
1983
160079
Titani K.,Fujikawa K.,Enfield D.L.,Ericsson L.H.,Walsh K.A.,Neurath H.
Bovine factor X1 (Stuart factor): amino-acid sequence of heavey chain.
Proc. Natl. Acad. Sci. U.S.A.
72
3082-3086
1975
160080
Inoue K.,Morita T.
Identification of O-linked oligosaccharide chains in the activation peptides of blood coagulation factor X. The role of the carbohydrate moieties in the activation of factor X.
Eur. J. Biochem.
218
153-163
1993
160081
Titani K.,Hermodson M.A.,Fujikawa K.,Ericsson L.H.,Walsh K.A.,Neurath H.,Davie E.W.
Bovine factor X 1a (activated Stuart factor). Evidence of homology with mammalian serine proteases.
Biochemistry
11
4899-4903
1972
160082
Fujikawa K.,Titani K.,Davie E.W.
Activation of bovine factor X (Stuart factor): conversion of factor Xa-alpha to factor Xa-beta.
Proc. Natl. Acad. Sci. U.S.A.
72
3359-3363
1975
160083
Sugo T.,Bjoerk I.,Holmgren A.,Stenflo J.
Calcium-binding properties of bovine factor X lacking the gamma-carboxyglutamic acid-containing region.
J. Biol. Chem.
259
5705-5710
1984
160084
Morita T.,Jackson C.M.
Localization of the structural difference between bovine blood coagulation factors X1 and X2 to tyrosine 18 in the activation peptide.
J. Biol. Chem.
261
4008-4014
1986
160085
Selander M.,Persson E.,Stenflo J.,Drakenberg T.
1H NMR assignment and secondary structure of the Ca2(+)-free form of the amino-terminal epidermal growth factor like domain in coagulation factor X.
Biochemistry
29
8111-8118
1990
160086
Ullner M.,Selander M.,Persson E.,Stenflo J.,Drakenberg T.,Teleman O.
Three-dimensional structure of the apo form of the N-terminal EGF-like module of blood coagulation factor X as determined by NMR spectroscopy and simulated folding.
Biochemistry
31
5974-5983
1992
160087
Selander-Sunnerhagen M.,Ullner M.,Persson E.,Teleman O.,Stenflo J.,Drakenberg T.
How an epidermal growth factor (EGF)-like domain binds calcium. High resolution NMR structure of the calcium form of the NH2-terminal EGF-like domain in coagulation factor X.
J. Biol. Chem.
267
19642-19649
1992
160088
Sunnerhagen M.,Olah G.A.,Stenflo J.,Forsen S.,Drakenberg T.,Trewhella J.
The relative orientation of Gla and EGF domains in coagulation factor X is altered by Ca2+ binding to the first EGF domain. A combined NMR-small angle X-ray scattering study.
Biochemistry
35
11547-11559
1996
