Sequence of CARC_PECCC
EC Number:1.14.20.3
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
(5R)-carbapenem-3-carboxylate synthase
Q9XB59
Pectobacterium carotovorum subsp. carotovorum
273
31611
Reaction
(3S,5S)-carbapenam-3-carboxylate + 2-oxoglutarate + O2 = (5R)-carbapen-2-em-3-carboxylate + succinate + CO2 + H2O
Other sequences found for EC No. 1.14.20.3
General information:
Sequence
0 MSEIVKFNPV MASGFGAYID HRDFLEAKTE TIKNLLMRQG FVVVKNLDID SDTFRDIYSA
60 YGTIVEYADE KIGVGFGYRD TLKLEGEKGK IVTGRGQLPF HADGGLLLSQ VDQVFLYAAE
120 IKNVKFRGAT TVCDHALACQ EMPAHLLRVL EEETFEVRVL ERGYYVDVSP DGWFKVPVFT
180 DLGWVRKMLI YFPFDEGQPA SWEPRIVGFT DHETQAFFQE LGAFLKQPRY YYKHFWEDGD
240 LLIMDNRRVI HEREEFNDDD IVRRLYRGQT ADI
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
13430
McGowan S.J.,Sebaihia M.,O'Leary S.,Hardie K.R.,Williams P.,Stewart G.S.,Bycroft B.W.,Salmond G.P.
Analysis of the carbapenem gene cluster of Erwinia carotovora: definition of the antibiotic biosynthetic genes and evidence for a novel beta-lactam resistance mechanism.
Mol. Microbiol.
26
545-556
1997
13431
Stapon A.,Li R.,Townsend C.A.
Carbapenem biosynthesis: confirmation of stereochemical assignments and the role of CarC in the ring stereoinversion process from L-proline.
J. Am. Chem. Soc.
125
8486-8493
2003
13432
Sleeman M.C.,Smith P.,Kellam B.,Chhabra S.R.,Bycroft B.W.,Schofield C.J.
Biosynthesis of carbapenem antibiotics: new carbapenam substrates for carbapenem synthase (CarC).
ChemBioChem
5
879-882
2004
13433
Clifton I.J.,Doan L.X.,Sleeman M.C.,Topf M.,Suzuki H.,Wilmouth R.C.,Schofield C.J.
Crystal structure of carbapenem synthase (CarC).
J. Biol. Chem.
278
20843-20850
2003
