Sequence of WNK4_MOUSE
EC Number:2.7.11.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate
Other sequences found for EC No. 2.7.11.1
General information:
Sequence
0 MLAPRNTETG VPMSQTEADL ALRPSPALTS TGPTRLGPPP RRVRRFSGKA EPRPRSSRPS
60 RRSSVDLGLL SSWSQPASLL PEPPDPPDSA GPTRSPPSSS KEPPEGTWMG AAPVKAVDSA
120 CPELTGSSGG PGSREPPRVP DAAARERRRE QEEKEDTETQ AVATSPDGRY LKFDIEIGRG
180 SFKTVYRGLD TDTTVEVAWC ELQTRKLSRA ERQRFSEEVE MLKGLQHPNI VRFYDSWKSV
240 LRGQVCIVLV TELMTSGTLK TYLRRFREMK PRVLQRWSRQ ILRGLHFLHS RVPPILHRDL
300 KCDNVFITGP SGSVKIGDLG LATLKRASFA KSVIGTPEFM APEMYEEKYD EAVDVYAFGM
360 CMLEMATSEY PYSECQNAAQ IYRKVTSGTK PNSFYKVKMP EVKEIIEGCI RTDKNERFTI
420 QDLLAHAFFR EERGVHVELA EEDDGEKPGL KLWLRMEDAR RGGRPRDNQA IEFLFQLGRD
480 AAEEVAQEMV ALGLVCEADY QPVARAVRER VAAIQRKREK LRKARELEVL PPDSGPPPAT
540 VSLAPGPPSA FPPEPEEPEA DQHQSFLFRH ASYSSTTSDC ETDGYLSSSG FLDASDPALQ
600 PPGGLPSSPA ESHLCLPSGF ALSIPRSGPG SDFSPGDSYA SDAASGLSDM GEGGQMRKNP
660 VKTLRRRPRS RLRVTSVSDQ SDRVVECQLQ THNSKMVTFR FDLDGDSPEE IAAAMVYNEF
720 ILPSERDGFL SRIREIIQRV ETLLKRDAGP PEAAEDALSP QEEPAALPAL PGPPNAEPQR
780 SISPEQRSWA AFSTSPSSPG TPLSPGAPFS PGTPPVFPCP IFPITSPSCY PCPFSQVSSN
840 PYPQAPSSLL PLSSSASQVP LPSSSLPISA PLPFSPSYPQ DPLSPTSLPV CPSPPSLPST
900 TAAPLLSLAS AFSLAVMTVA QSLLSPSPGL LSQSPPAPPG PLPSLPLSLA SCDQESLSAQ
960 TAETENEASR NPAQPLLGDA RLAPISEEGK PQLVGRFQVT SSKEPAEPPL QPASPTLSRS
1020 LKLPSPPLTS ESSDTEDSAA GGPETREALA ESDRAAEGLG VAVDDEKDEG KEPLLGGSSP
1080 ILSHPSPVWM NYSYSSLCLS SEESESSGED EEFWAELQNL RQKHLSEVEA LQTLQKKEIE
1140 DLYSRLGKQP PPGIVAPAAM LSCRQRRLSK GSFPTSRRNS LQRSDLPGPG IMRRNSLSGS
1200 STGSQEQRAS KGVTFAGDIG RM
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
118251
Wilson F.H.,Kahle K.T.,Sabath E.,Lalioti M.D.,Rapson A.K.,Hoover R.S.,Hebert S.C.,Gamba G.,Lifton R.P.
Molecular pathogenesis of inherited hypertension with hyperkalemia: The Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4.
Proc. Natl. Acad. Sci. U.S.A.
100
680-684
2003
118252
Yang C.-L.,Angell J.,Mitchell R.,Ellison D.H.
WNK kinases regulate thiazide-sensitive Na-Cl cotransport.
J. Clin. Invest.
111
1039-1045
2003
118253
Church D.M.,Goodstadt L.,Hillier L.W.,Zody M.C.,Goldstein S.,She X.,Bult C.J.,Agarwala R.,Cherry J.L.,DiCuccio M.,Hlavina W.,Kapustin Y.,Meric P.,Maglott D.,Birtle Z.,Marques A.C.,Graves T.,Zhou S.,Teague B.,Potamousis K.,Churas C.,Place M.,Herschleb J.,Runnheim R.,Forrest D.,Amos-Landgraf J.,Schwartz D.C.,Cheng Z.,Lindblad-Toh K.,Eichler E.E.,Ponting C.P.
Lineage-specific biology revealed by a finished genome assembly of the mouse.
PLoS Biol.
7
0-0
2009
118254
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
118255
Wilson F.H.,Disse-Nicodeme S.,Choate K.A.,Ishikawa K.,Nelson-Williams C.,Desitter I.,Gunel M.,Milford D.V.,Lipkin G.W.,Achard J.-M.,Feely M.P.,Dussol B.,Berland Y.,Unwin R.J.,Mayan H.,Simon D.B.,Farfel Z.,Jeunemaitre X.,Lifton R.P.
Human hypertension caused by mutations in WNK kinases.
Science
293
1107-1112
2001
118256
Kahle K.T.,Wilson F.H.,Leng Q.,Lalioti M.D.,O'Connell A.D.,Dong K.,Rapson A.K.,MacGregor G.G.,Giebisch G.,Hebert S.C.,Lifton R.P.
WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion.
Nat. Genet.
35
372-376
2003
118257
Yang C.L.,Zhu X.,Ellison D.H.
The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex.
J. Clin. Invest.
117
3403-3411
2007
118258
Huttlin E.L.,Jedrychowski M.P.,Elias J.E.,Goswami T.,Rad R.,Beausoleil S.A.,Villen J.,Haas W.,Sowa M.E.,Gygi S.P.
A tissue-specific atlas of mouse protein phosphorylation and expression.
Cell
143
1174-1189
2010
118259
Yang D.,Li Q.,So I.,Huang C.L.,Ando H.,Mizutani A.,Seki G.,Mikoshiba K.,Thomas P.J.,Muallem S.
IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway.
J. Clin. Invest.
121
956-965
2011
118260
Wakabayashi M.,Mori T.,Isobe K.,Sohara E.,Susa K.,Araki Y.,Chiga M.,Kikuchi E.,Nomura N.,Mori Y.,Matsuo H.,Murata T.,Nomura S.,Asano T.,Kawaguchi H.,Nonoyama S.,Rai T.,Sasaki S.,Uchida S.
Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension.
Cell Rep.
3
858-868
2013
118261
Shibata S.,Zhang J.,Puthumana J.,Stone K.L.,Lifton R.P.
Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4.
Proc. Natl. Acad. Sci. U.S.A.
110
7838-7843
2013
