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Sequence of MIF_HUMAN

EC Number:5.3.2.1

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
phenylpyruvate tautomerase
P14174
Homo sapiens
115
12476
Reaction
Keto-phenylpyruvate = enol-phenylpyruvate
Other sequences found for EC No. 5.3.2.1

General information:

Sequence
show sequence in fasta format
  0 MPMFIVNTNV PRASVPDGFL SELTQQLAQA TGKPPQYIAV HVVPDQLMAF GGSSEPCALC
 60 SLHSIGKIGG AQNRSYSKLL CGLLAERLRI SPDRVYINYY DMNAANVGWN NSTFA
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1213639
Weiser W.Y.,Temple P.A.,Witek-Giannotti J.S.,Remold H.G.,Clark S.C.,David J.R.
Molecular cloning of a cDNA encoding a human macrophage migration inhibitory factor.
Proc. Natl. Acad. Sci. U.S.A.
86
7522-7526
1989
1213640
Mikayama T.,Nakano T.,Gomi H.,Nakagawa Y.,Liu Y.C.,Iwamatsu A.,Weiser W.Y.,Ishizaka K.,Sato M.,Ishii Y.
Molecular cloning and functional expression of a cDNA encoding glycosylation-inhibiting factor.
Proc. Natl. Acad. Sci. U.S.A.
90
10056-10060
1993
1213641
Bernhagen J.,Mitchell R.A.,Calandra T.,Voelter W.,Cerami A.,Bucala R.
Purification, bioactivity, and secondary structure analysis of mouse and human macrophage migration inhibitory factor (MIF).
Biochemistry
33
14144-14155
1994
1213642
Paralkar V.,Wistow G.J.
Cloning the human gene for macrophage migration inhibitory factor (MIF).
Genomics
19
48-51
1994
1213645
Collins J.E.,Wright C.L.,Edwards C.A.,Davis M.P.,Grinham J.A.,Cole C.G.,Goward M.E.,Aguado B.,Mallya M.,Mokrab Y.,Huckle E.J.,Beare D.M.,Dunham I.
A genome annotation-driven approach to cloning the human ORFeome.
Genome Biol.
5
0-0
2004
1213646
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
1213651
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
1213652
Gevaert K.,Goethals M.,Martens L.,Van Damme J.,Staes A.,Thomas G.R.,Vandekerckhove J.
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
Nat. Biotechnol.
21
566-569
2003
1213653
Hochstrasser D.F.,Frutiger S.,Paquet N.,Bairoch A.,Ravier F.,Pasquali C.,Sanchez J.-C.,Tissot J.-D.,Bjellqvist B.,Vargas R.,Appel R.D.,Hughes G.J.
Human liver protein map: a reference database established by microsequencing and gel comparison.
Electrophoresis
13
992-1001
1992
1213654
Zeng F.Y.,Weiser W.Y.,Kratzin H.,Stahl B.,Karas M.,Gabius H.J.
The major binding protein of the interferon antagonist sarcolectin in human placenta is a macrophage migration inhibitory factor.
Arch. Biochem. Biophys.
303
74-80
1993
1213655
Wistow G.J.,Shaughnessy M.,Lee D.C.,Hodin J.,Zelenka P.S.
A macrophage migration inhibitory factor is expressed in the differentiating cells of the eye lens.
Proc. Natl. Acad. Sci. U.S.A.
90
1272-1275
1993
1213656
Kleemann R.,Hausser A.,Geiger G.,Mischke R.,Burger-Kentischer A.,Flieger O.,Johannes F.-J.,Roger T.,Calandra T.,Kapurniotu A.,Grell M.,Finkelmeier D.,Brunner H.,Bernhagen J.
Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1.
Nature
408
211-216
2000
1213657
Donn R.P.,Shelley E.,Ollier W.E.R.,Thomson W.
A novel 5'-flanking region polymorphism of macrophage migration inhibitory factor is associated with systemic-onset juvenile idiopathic arthritis.
Arthritis Rheum.
44
1782-1785
2001
1213658
Tan T.H.P.,Edgerton S.A.V.,Kumari R.,McAlister M.S.B.,Roe S.M.,Nagl S.,Pearl L.H.,Selkirk M.E.,Bianco A.E.,Totty N.F.,Engwerda C.,Gray C.A.,Meyer D.J.,Rowe S.M.
Macrophage migration inhibitory factor of the parasitic nematode Trichinella spiralis.
Biochem. J.
357
373-383
2001
1213659
Shen L.,Hu J.,Lu H.,Wu M.,Qin W.,Wan D.,Li Y.-Y.,Gu J.
The apoptosis-associated protein BNIPL interacts with two cell proliferation-related proteins, MIF and GFER.
FEBS Lett.
540
86-90
2003
1213660
Leng L.,Metz C.N.,Fang Y.,Xu J.,Donnelly S.,Baugh J.,Delohery T.,Chen Y.,Mitchell R.A.,Bucala R.
MIF signal transduction initiated by binding to CD74.
J. Exp. Med.
197
1467-1476
2003
1213661
Oddo M.,Calandra T.,Bucala R.,Meylan P.R.A.
Macrophage migration inhibitory factor reduces the growth of virulent Mycobacterium tuberculosis in human macrophages.
Infect. Immun.
73
3783-3786
2005
1213662
Emonts M.,Sweep F.C.G.J.,Grebenchtchikov N.,Geurts-Moespot A.,Knaup M.,Chanson A.L.,Erard V.,Renner P.,Hermans P.W.M.,Hazelzet J.A.,Calandra T.
Association between high levels of blood macrophage migration inhibitory factor, inappropriate adrenal response, and early death in patients with severe sepsis.
Clin. Infect. Dis.
44
1321-1328
2007
1213663
Merk M.,Baugh J.,Zierow S.,Leng L.,Pal U.,Lee S.J.,Ebert A.D.,Mizue Y.,Trent J.O.,Mitchell R.,Nickel W.,Kavathas P.B.,Bernhagen J.,Bucala R.
The Golgi-associated protein p115 mediates the secretion of macrophage migration inhibitory factor.
J. Immunol.
182
6896-6906
2009
1213664
Choudhary C.,Kumar C.,Gnad F.,Nielsen M.L.,Rehman M.,Walther T.C.,Olsen J.V.,Mann M.
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Science
325
834-840
2009
1213665
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
1213666
Bienvenut W.V.,Sumpton D.,Martinez A.,Lilla S.,Espagne C.,Meinnel T.,Giglione C.
Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
Mol. Cell. Proteomics
11
0-0
2012
1213667
Van Damme P.,Lasa M.,Polevoda B.,Gazquez C.,Elosegui-Artola A.,Kim D.S.,De Juan-Pardo E.,Demeyer K.,Hole K.,Larrea E.,Timmerman E.,Prieto J.,Arnesen T.,Sherman F.,Gevaert K.,Aldabe R.
N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
Proc. Natl. Acad. Sci. U.S.A.
109
12449-12454
2012
1213668
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
1213669
Vaca Jacome A.S.,Rabilloud T.,Schaeffer-Reiss C.,Rompais M.,Ayoub D.,Lane L.,Bairoch A.,Van Dorsselaer A.,Carapito C.
N-terminome analysis of the human mitochondrial proteome.
Proteomics
15
2519-2524
2015
1213670
Sugimoto H.,Suzuki M.,Nakagawa A.,Tanaka I.,Nishihira J.
Crystal structure of macrophage migration inhibitory factor from human lymphocyte at 2.1-A resolution.
FEBS Lett.
389
145-148
1996
1213671
Kato Y.,Muto T.,Tomura T.,Tsumura H.,Watarai H.,Mikayama T.,Ishizaka K.,Kuroki R.
The crystal structure of human glycosylation-inhibiting factor is a trimeric barrel with three 6-stranded beta-sheets.
Proc. Natl. Acad. Sci. U.S.A.
93
3007-3010
1996
1213672
Sun H.W.,Bernhagen J.,Bucala R.,Lolis E.
Crystal structure at 2.6-A resolution of human macrophage migration inhibitory factor.
Proc. Natl. Acad. Sci. U.S.A.
93
5191-5196
1996
1213673
Lubetsky J.B.,Swope M.,Dealwis C.,Blake P.,Lolis E.
Pro-1 of macrophage migration inhibitory factor functions as a catalytic base in the phenylpyruvate tautomerase activity.
Biochemistry
38
7346-7354
1999
1213674
Orita M.,Yamamoto S.,Katayama N.,Aoki M.,Takayama K.,Yamagiwa Y.,Seki N.,Suzuki H.,Kurihara H.,Sakashita H.,Takeuchi M.,Fujita S.,Yamada T.,Tanaka A.
Coumarin and chromen-4-one analogues as tautomerase inhibitors of macrophage migration inhibitory factor: discovery and X-ray crystallography.
J. Med. Chem.
44
540-547
2001
1213675
Crichlow G.V.,Cheng K.F.,Dabideen D.,Ochani M.,Aljabari B.,Pavlov V.A.,Miller E.J.,Lolis E.,Al-Abed Y.
Alternative chemical modifications reverse the binding orientation of a pharmacophore scaffold in the active site of macrophage migration inhibitory factor.
J. Biol. Chem.
282
23089-23095
2007
1213676
Crichlow G.V.,Lubetsky J.B.,Leng L.,Bucala R.,Lolis E.J.
Structural and kinetic analyses of macrophage migration inhibitory factor active site interactions.
Biochemistry
48
132-139
2009
1213677
Fan C.,Rajasekaran D.,Syed M.A.,Leng L.,Loria J.P.,Bhandari V.,Bucala R.,Lolis E.J.
MIF intersubunit disulfide mutant antagonist supports activation of CD74 by endogenous MIF trimer at physiologic concentrations.
Proc. Natl. Acad. Sci. U.S.A.
110
10994-10999
2013