Sequence of AFLD_ASPPU
EC Number:1.1.1.349
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
norsolorinic acid ketoreductase
Q00278
Aspergillus parasiticus (strain ATCC 56775 / NRRL 5862 / SRRC 143 / SU-1)
271
29569
Reaction
(1'S)-averantin + NADP+ = norsolorinic acid + NADPH + H+
Other sequences found for EC No. 1.1.1.349
General information:
Sequence
0 MNGSLSQHDQ ERLSTPYRDG PPEETVYLVT GASRGIGRGL IEAFLQRPKS TVVAWLRNVR
60 TATPALSALT VAEGSRMIIV QLNSDSETDA QAAVQTLREE HGVTHLDVVV ANAAMATNFG
120 PASTMPLEHL QAHMMVNMYA PVLLFQATRL MLQQSKQQAK FVLIGAPIST ITNMHDYSRA
180 PLTAYGVSKL AANYMVRKFH FENKWLTAFI IDPGHVQTDM GDQGARLMGR PQAPTTVADS
240 VAGICARIDE ATKETTSGHF VIHTDGSQLP W
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1154666
Trail F.,Chang P.-K.,Cary J.,Linz J.E.
Structural and functional analysis of the nor-1 gene involved in the biosynthesis of aflatoxins by Aspergillus parasiticus.
Appl. Environ. Microbiol.
60
4078-4085
1994
1154667
Yu J.,Bhatnagar D.,Cleveland T.E.
Completed sequence of aflatoxin pathway gene cluster in Aspergillus parasiticus.
FEBS Lett.
564
126-130
2004
1154669
Skory C.D.,Chang P.K.,Cary J.,Linz J.E.
Isolation and characterization of a gene from Aspergillus parasiticus associated with the conversion of versicolorin A to sterigmatocystin in aflatoxin biosynthesis.
Appl. Environ. Microbiol.
58
3527-3537
1992
1154670
Keller N.P.,Dischinger H.C. Jr.,Bhatnager D.,Cleveland T.E.,Ullah A.H.J.
Purification of a 40-kilodalton methyltransferase active in the aflatoxin biosynthetic pathway.
Appl. Environ. Microbiol.
59
479-484
1993
1154671
Yabe K.,Matsuyama Y.,Ando Y.,Nakajima H.,Hamasaki T.
Stereochemistry during aflatoxin biosynthesis: conversion of norsolorinic acid to averufin.
Appl. Environ. Microbiol.
59
2486-2492
1993
1154672
Yabe K.,Hamasaki T.
Stereochemistry during aflatoxin biosynthesis: cyclase reaction in the conversion of versiconal to versicolorin B and racemization of versiconal hemiacetal acetate.
Appl. Environ. Microbiol.
59
2493-2500
1993
1154673
Motomura M.,Chihaya N.,Shinozawa T.,Hamasaki T.,Yabe K.
Cloning and characterization of the O-methyltransferase I gene (dmtA) from Aspergillus parasiticus associated with the conversions of demethylsterigmatocystin to sterigmatocystin and dihydrodemethylsterigmatocystin to dihydrosterigmatocystin in aflatoxin biosynthesis.
Appl. Environ. Microbiol.
65
4987-4994
1999
1154674
Zhou R.,Linz J.E.
Enzymatic function of the nor-1 protein in aflatoxin biosynthesis in Aspergillus parasiticus.
Appl. Environ. Microbiol.
65
5639-5641
1999
1154675
Chang P.K.,Yu J.,Ehrlich K.C.,Boue S.M.,Montalbano B.G.,Bhatnagar D.,Cleveland T.E.
adhA in Aspergillus parasiticus is involved in conversion of 5'-hydroxyaverantin to averufin.
Appl. Environ. Microbiol.
66
4715-4719
2000
1154676
Hitchman T.S.,Schmidt E.W.,Trail F.,Rarick M.D.,Linz J.E.,Townsend C.A.
Hexanoate synthase, a specialized type I fatty acid synthase in aflatoxin B1 biosynthesis.
Bioorg. Chem.
29
293-307
2001
1154677
Udwary D.W.,Casillas L.K.,Townsend C.A.
Synthesis of 11-hydroxyl O-methylsterigmatocystin and the role of a cytochrome P-450 in the final step of aflatoxin biosynthesis.
J. Am. Chem. Soc.
124
5294-5303
2002
1154678
Yu J.,Chang P.K.,Ehrlich K.C.,Cary J.W.,Bhatnagar D.,Cleveland T.E.,Payne G.A.,Linz J.E.,Woloshuk C.P.,Bennett J.W.
Clustered pathway genes in aflatoxin biosynthesis.
Appl. Environ. Microbiol.
70
1253-1262
2004
1154679
Ehrlich K.C.,Chang P.K.,Yu J.,Cotty P.J.
Aflatoxin biosynthesis cluster gene cypA is required for G aflatoxin formation.
Appl. Environ. Microbiol.
70
6518-6524
2004
1154680
Lee L.W.,Chiou C.H.,Klomparens K.L.,Cary J.W.,Linz J.E.
Subcellular localization of aflatoxin biosynthetic enzymes Nor-1, Ver-1, and OmtA in time-dependent fractionated colonies of Aspergillus parasiticus.
Arch. Microbiol.
181
204-214
2004
1154681
Roze L.V.,Miller M.J.,Rarick M.,Mahanti N.,Linz J.E.
A novel cAMP-response element, CRE1, modulates expression of nor-1 in Aspergillus parasiticus.
J. Biol. Chem.
279
27428-27439
2004
1154682
Miller M.J.,Roze L.V.,Trail F.,Linz J.E.
Role of cis-acting sites NorL, a TATA box, and AflR1 in nor-1 transcriptional activation in Aspergillus parasiticus.
Appl. Environ. Microbiol.
71
1539-1545
2005
1154683
Sakuno E.,Wen Y.,Hatabayashi H.,Arai H.,Aoki C.,Yabe K.,Nakajima H.
Aspergillus parasiticus cyclase catalyzes two dehydration steps in aflatoxin biosynthesis.
Appl. Environ. Microbiol.
71
2999-3006
2005
1154684
Ehrlich K.C.,Montalbano B.,Boue S.M.,Bhatnagar D.
An aflatoxin biosynthesis cluster gene encodes a novel oxidase required for conversion of versicolorin a to sterigmatocystin.
Appl. Environ. Microbiol.
71
8963-8965
2005
1154685
Henry K.M.,Townsend C.A.
Ordering the reductive and cytochrome P450 oxidative steps in demethylsterigmatocystin formation yields general insights into the biosynthesis of aflatoxin and related fungal metabolites.
J. Am. Chem. Soc.
127
3724-3733
2005
1154686
Cary J.W.,Ehrlich K.C.,Bland J.M.,Montalbano B.G.
The aflatoxin biosynthesis cluster gene, aflX, encodes an oxidoreductase involved in conversion of versicolorin A to demethylsterigmatocystin.
Appl. Environ. Microbiol.
72
1096-1101
2006
1154687
Cai J.,Zeng H.,Shima Y.,Hatabayashi H.,Nakagawa H.,Ito Y.,Adachi Y.,Nakajima H.,Yabe K.
Involvement of the nadA gene in formation of G-group aflatoxins in Aspergillus parasiticus.
Fungal Genet. Biol.
45
1081-1093
2008
1154688
Crawford J.M.,Thomas P.M.,Scheerer J.R.,Vagstad A.L.,Kelleher N.L.,Townsend C.A.
Deconstruction of iterative multidomain polyketide synthase function.
Science
320
243-246
2008
1154689
Hong S.Y.,Linz J.E.
Functional expression and sub-cellular localization of the early aflatoxin pathway enzyme Nor-1 in Aspergillus parasiticus.
Mycol. Res.
113
591-601
2009
1154690
Abdel-Hadi A.M.,Caley D.P.,Carter D.R.,Magan N.
Control of aflatoxin production of Aspergillus flavus and Aspergillus parasiticus using RNA silencing technology by targeting aflD (nor-1) gene.
Toxins
3
647-659
2011
1154691
Jahanshiri Z.,Shams-Ghahfarokhi M.,Allameh A.,Razzaghi-Abyaneh M.
Effect of curcumin on Aspergillus parasiticus growth and expression of major genes involved in the early and late stages of aflatoxin biosynthesis.
Iran. J. Public Health
41
72-79
2012
1154692
Yahyaraeyat R.,Khosravi A.R.,Shahbazzadeh D.,Khalaj V.
The potential effects of Zataria multiflora Boiss essential oil on growth, aflatoxin production and transcription of aflatoxin biosynthesis pathway genes of toxigenic Aspergillus parasiticus.
Braz. J. Microbiol.
44
643-649
2013
1154693
Yin H.B.,Chen C.H.,Kollanoor-Johny A.,Darre M.J.,Venkitanarayanan K.
Controlling Aspergillus flavus and Aspergillus parasiticus growth and aflatoxin production in poultry feed using carvacrol and trans-cinnamaldehyde.
Poult. Sci.
94
2183-2190
2015
