Sequence of XIAP_HUMAN
EC Number:2.3.2.27
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine
Other sequences found for EC No. 2.3.2.27
General information:
Sequence
0 MTFNSFEGSK TCVPADINKE EEFVEEFNRL KTFANFPSGS PVSASTLARA GFLYTGEGDT
60 VRCFSCHAAV DRWQYGDSAV GRHRKVSPNC RFINGFYLEN SATQSTNSGI QNGQYKVENY
120 LGSRDHFALD RPSETHADYL LRTGQVVDIS DTIYPRNPAM YSEEARLKSF QNWPDYAHLT
180 PRELASAGLY YTGIGDQVQC FCCGGKLKNW EPCDRAWSEH RRHFPNCFFV LGRNLNIRSE
240 SDAVSSDRNF PNSTNLPRNP SMADYEARIF TFGTWIYSVN KEQLARAGFY ALGEGDKVKC
300 FHCGGGLTDW KPSEDPWEQH AKWYPGCKYL LEQKGQEYIN NIHLTHSLEE CLVRTTEKTP
360 SLTRRIDDTI FQNPMVQEAI RMGFSFKDIK KIMEEKIQIS GSNYKSLEVL VADLVNAQKD
420 SMQDESSQTS LQKEISTEEQ LRRLQEEKLC KICMDRNIAI VFVPCGHLVT CKQCAEAVDK
480 CPMCYTVITF KQKIFMS
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1143879
Duckett C.S.,Nava V.E.,Gedrich R.W.,Clem R.J.,van Dongen J.L.,Gilfillan M.C.,Shiels H.,Hardwick J.M.,Thompson C.B.
A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors.
EMBO J.
15
2685-2694
1996
1143880
Liston P.,Roy N.,Tamai K.,Lefebvre C.,Baird S.,Cherton-Horvat G.,Farahani R.,McLean M.,Ikeda J.,Mackenzie A.,Korneluk R.G.
Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes.
Nature
379
349-353
1996
1143882
Ross M.T.,Grafham D.V.,Coffey A.J.,Scherer S.,McLay K.,Muzny D.,Platzer M.,Howell G.R.,Burrows C.,Bird C.P.,Frankish A.,Lovell F.L.,Howe K.L.,Ashurst J.L.,Fulton R.S.,Sudbrak R.,Wen G.,Jones M.C.,Hurles M.E.,Andrews T.D.,Scott C.E.,Searle S.,Ramser J.,Whittaker A.,Deadman R.,Carter N.P.,Hunt S.E.,Chen R.,Cree A.,Gunaratne P.,Havlak P.,Hodgson A.,Metzker M.L.,Richards S.,Scott G.,Steffen D.,Sodergren E.,Wheeler D.A.,Worley K.C.,Ainscough R.,Ambrose K.D.,Ansari-Lari M.A.,Aradhya S.,Ashwell R.I.,Babbage A.K.,Bagguley C.L.,Ballabio A.,Banerjee R.,Barker G.E.,Barlow K.F.,Barrett I.P.,Bates K.N.,Beare D.M.,Beasley H.,Beasley O.,Beck A.,Bethel G.,Blechschmidt K.,Brady N.,Bray-Allen S.,Bridgeman A.M.,Brown A.J.,Brown M.J.,Bonnin D.,Bruford E.A.,Buhay C.,Burch P.,Burford D.,Burgess J.,Burrill W.,Burton J.,Bye J.M.,Carder C.,Carrel L.,Chako J.,Chapman J.C.,Chavez D.,Chen E.,Chen G.,Chen Y.,Chen Z.,Chinault C.,Ciccodicola A.,Clark S.Y.,Clarke G.,Clee C.M.,Clegg S.,Clerc-Blankenburg K.,Clifford K.,Cobley V.,Cole C.G.,Conquer J.S.,Corby N.,Connor R.E.,David R.,Davies J.,Davis C.,Davis J.,Delgado O.,Deshazo D.,Dhami P.,Ding Y.,Dinh H.,Dodsworth S.,Draper H.,Dugan-Rocha S.,Dunham A.,Dunn M.,Durbin K.J.,Dutta I.,Eades T.,Ellwood M.,Emery-Cohen A.,Errington H.,Evans K.L.,Faulkner L.,Francis F.,Frankland J.,Fraser A.E.,Galgoczy P.,Gilbert J.,Gill R.,Gloeckner G.,Gregory S.G.,Gribble S.,Griffiths C.,Grocock R.,Gu Y.,Gwilliam R.,Hamilton C.,Hart E.A.,Hawes A.,Heath P.D.,Heitmann K.,Hennig S.,Hernandez J.,Hinzmann B.,Ho S.,Hoffs M.,Howden P.J.,Huckle E.J.,Hume J.,Hunt P.J.,Hunt A.R.,Isherwood J.,Jacob L.,Johnson D.,Jones S.,de Jong P.J.,Joseph S.S.,Keenan S.,Kelly S.,Kershaw J.K.,Khan Z.,Kioschis P.,Klages S.,Knights A.J.,Kosiura A.,Kovar-Smith C.,Laird G.K.,Langford C.,Lawlor S.,Leversha M.,Lewis L.,Liu W.,Lloyd C.,Lloyd D.M.,Loulseged H.,Loveland J.E.,Lovell J.D.,Lozado R.,Lu J.,Lyne R.,Ma J.,Maheshwari M.,Matthews L.H.,McDowall J.,McLaren S.,McMurray A.,Meidl P.,Meitinger T.,Milne S.,Miner G.,Mistry S.L.,Morgan M.,Morris S.,Mueller I.,Mullikin J.C.,Nguyen N.,Nordsiek G.,Nyakatura G.,O'dell C.N.,Okwuonu G.,Palmer S.,Pandian R.,Parker D.,Parrish J.,Pasternak S.,Patel D.,Pearce A.V.,Pearson D.M.,Pelan S.E.,Perez L.,Porter K.M.,Ramsey Y.,Reichwald K.,Rhodes S.,Ridler K.A.,Schlessinger D.,Schueler M.G.,Sehra H.K.,Shaw-Smith C.,Shen H.,Sheridan E.M.,Shownkeen R.,Skuce C.D.,Smith M.L.,Sotheran E.C.,Steingruber H.E.,Steward C.A.,Storey R.,Swann R.M.,Swarbreck D.,Tabor P.E.,Taudien S.,Taylor T.,Teague B.,Thomas K.,Thorpe A.,Timms K.,Tracey A.,Trevanion S.,Tromans A.C.,d'Urso M.,Verduzco D.,Villasana D.,Waldron L.,Wall M.,Wang Q.,Warren J.,Warry G.L.,Wei X.,West A.,Whitehead S.L.,Whiteley M.N.,Wilkinson J.E.,Willey D.L.,Williams G.,Williams L.,Williamson A.,Williamson H.,Wilming L.,Woodmansey R.L.,Wray P.W.,Yen J.,Zhang J.,Zhou J.,Zoghbi H.,Zorilla S.,Buck D.,Reinhardt R.,Poustka A.,Rosenthal A.,Lehrach H.,Meindl A.,Minx P.J.,Hillier L.W.,Willard H.F.,Wilson R.K.,Waterston R.H.,Rice C.M.,Vaudin M.,Coulson A.,Nelson D.L.,Weinstock G.,Sulston J.E.,Durbin R.M.,Hubbard T.,Gibbs R.A.,Beck S.,Rogers J.,Bentley D.R.
The DNA sequence of the human X chromosome.
Nature
434
325-337
2005
1143884
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
1143885
Deveraux Q.L.,Takahashi R.,Salvesen G.S.,Reed J.C.
X-linked IAP is a direct inhibitor of cell-death proteases.
Nature
388
300-304
1997
1143886
Suzuki Y.,Nakabayashi Y.,Takahashi R.
Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death.
Proc. Natl. Acad. Sci. U.S.A.
98
8662-8667
2001
1143887
Verhagen A.M.,Silke J.,Ekert P.G.,Pakusch M.,Kaufmann H.,Connolly L.M.,Day C.L.,Tikoo A.,Burke R.,Wrobel C.,Moritz R.L.,Simpson R.J.,Vaux D.L.
HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins.
J. Biol. Chem.
277
445-454
2002
1143888
MacFarlane M.,Merrison W.,Bratton S.B.,Cohen G.M.
Proteasome-mediated degradation of Smac during apoptosis: XIAP promotes Smac ubiquitination in vitro.
J. Biol. Chem.
277
36611-36616
2002
1143889
Shin H.,Okada K.,Wilkinson J.C.,Solomon K.M.,Duckett C.S.,Reed J.C.,Salvesen G.S.
Identification of ubiquitination sites on the X-linked inhibitor of apoptosis protein.
Biochem. J.
373
965-971
2003
1143890
Burstein E.,Ganesh L.,Dick R.D.,van De Sluis B.,Wilkinson J.C.,Klomp L.W.,Wijmenga C.,Brewer G.J.,Nabel G.J.,Duckett C.S.
A novel role for XIAP in copper homeostasis through regulation of MURR1.
EMBO J.
23
244-254
2004
1143891
Gottfried Y.,Rotem A.,Lotan R.,Steller H.,Larisch S.
The mitochondrial ARTS protein promotes apoptosis through targeting XIAP.
EMBO J.
23
1627-1635
2004
1143892
Dan H.C.,Sun M.,Kaneko S.,Feldman R.I.,Nicosia S.V.,Wang H.-G.,Tsang B.K.,Cheng J.Q.
Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP).
J. Biol. Chem.
279
5405-5412
2004
1143893
Dan H.C.,Sun M.,Kaneko S.,Feldman R.I.,Nicosia S.V.,Wang H.G.,Tsang B.K.,Cheng J.Q.
J. Biol. Chem.
291
22846-22846
2016
1143894
Samuel T.,Okada K.,Hyer M.,Welsh K.,Zapata J.M.,Reed J.C.
cIAP1 Localizes to the nuclear compartment and modulates the cell cycle.
Cancer Res.
65
210-218
2005
1143895
Rigaud S.,Fondaneche M.-C.,Lambert N.,Pasquier B.,Mateo V.,Soulas P.,Galicier L.,Le Deist F.,Rieux-Laucat F.,Revy P.,Fischer A.,de Saint Basile G.,Latour S.
XIAP deficiency in humans causes an X-linked lymphoproliferative syndrome.
Nature
444
110-114
2006
1143896
Mufti A.R.,Burstein E.,Duckett C.S.
XIAP: cell death regulation meets copper homeostasis.
Arch. Biochem. Biophys.
463
168-174
2007
1143897
Steen H.,Lindholm D.
Nuclear localized protein-1 (Nulp1) increases cell death of human osteosarcoma cells and binds the X-linked inhibitor of apoptosis protein.
Biochem. Biophys. Res. Commun.
366
432-437
2008
1143898
Dubrez-Daloz L.,Dupoux A.,Cartier J.
IAPs: more than just inhibitors of apoptosis proteins.
Cell Cycle
7
1036-1046
2008
1143899
Bisson W.H.,Zhang Z.,Welsh K.,Huang J.W.,Ryan J.,Reed J.C.,Pellecchia M.
Binding properties of the C-terminal domain of VIAF.
Chem. Biol. Drug Des.
72
331-336
2008
1143900
Wilkinson J.C.,Wilkinson A.S.,Galban S.,Csomos R.A.,Duckett C.S.
Apoptosis-inducing factor is a target for ubiquitination through interaction with XIAP.
Mol. Cell. Biol.
28
237-247
2008
1143901
Dephoure N.,Zhou C.,Villen J.,Beausoleil S.A.,Bakalarski C.E.,Elledge S.J.,Gygi S.P.
A quantitative atlas of mitotic phosphorylation.
Proc. Natl. Acad. Sci. U.S.A.
105
10762-10767
2008
1143902
Van Themsche C.,Leblanc V.,Parent S.,Asselin E.
X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization.
J. Biol. Chem.
284
20462-20466
2009
1143903
Kang Y.J.,Jang M.,Park Y.K.,Kang S.,Bae K.H.,Cho S.,Lee C.K.,Park B.C.,Chi S.W.,Park S.G.
Molecular interaction between HAX-1 and XIAP inhibits apoptosis.
Biochem. Biophys. Res. Commun.
393
794-799
2010
1143904
Lopez J.,Meier P.
To fight or die - inhibitor of apoptosis proteins at the crossroad of innate immunity and death.
Curr. Opin. Cell Biol.
22
872-881
2010
1143905
Nakamura T.,Wang L.,Wong C.C.,Scott F.L.,Eckelman B.P.,Han X.,Tzitzilonis C.,Meng F.,Gu Z.,Holland E.A.,Clemente A.T.,Okamoto S.,Salvesen G.S.,Riek R.,Yates J.R. III,Lipton S.A.
Transnitrosylation of XIAP regulates caspase-dependent neuronal cell death.
Mol. Cell
39
184-195
2010
1143906
Broemer M.,Tenev T.,Rigbolt K.T.,Hempel S.,Blagoev B.,Silke J.,Ditzel M.,Meier P.
Systematic in vivo RNAi analysis identifies IAPs as NEDD8-E3 ligases.
Mol. Cell
40
810-822
2010
1143907
Brady G.F.,Galban S.,Liu X.,Basrur V.,Gitlin J.D.,Elenitoba-Johnson K.S.,Wilson T.E.,Duckett C.S.
Regulation of the copper chaperone CCS by XIAP-mediated ubiquitination.
Mol. Cell. Biol.
30
1923-1936
2010
1143908
Gyrd-Hansen M.,Meier P.
IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer.
Nat. Rev. Cancer
10
561-574
2010
1143909
Bornstein B.,Gottfried Y.,Edison N.,Shekhtman A.,Lev T.,Glaser F.,Larisch S.
ARTS binds to a distinct domain in XIAP-BIR3 and promotes apoptosis by a mechanism that is different from other IAP-antagonists.
Apoptosis
16
869-881
2011
1143910
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
1143911
Lewis E.M.,Wilkinson A.S.,Davis N.Y.,Horita D.A.,Wilkinson J.C.
Nondegradative ubiquitination of apoptosis inducing factor (AIF) by X-linked inhibitor of apoptosis at a residue critical for AIF-mediated chromatin degradation.
Biochemistry
50
11084-11096
2011
1143912
Damgaard R.B.,Gyrd-Hansen M.
Inhibitor of apoptosis (IAP) proteins in regulation of inflammation and innate immunity.
Discov. Med.
11
221-231
2011
1143913
Pavlyukov M.S.,Antipova N.V.,Balashova M.V.,Vinogradova T.V.,Kopantzev E.P.,Shakhparonov M.I.
Survivin monomer plays an essential role in apoptosis regulation.
J. Biol. Chem.
286
23296-23307
2011
1143914
Mei Y.,Hahn A.A.,Hu S.,Yang X.
The USP19 deubiquitinase regulates the stability of c-IAP1 and c-IAP2.
J. Biol. Chem.
286
35380-35387
2011
1143915
Bertrand M.J.,Lippens S.,Staes A.,Gilbert B.,Roelandt R.,De Medts J.,Gevaert K.,Declercq W.,Vandenabeele P.
cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4).
PLoS ONE
6
0-0
2011
1143917
Koren E.,Yosefzon Y.,Ankawa R.,Soteriou D.,Jacob A.,Nevelsky A.,Ben-Yosef R.,Bar-Sela G.,Fuchs Y.
ARTS mediates apoptosis and regeneration of the intestinal stem cell niche.
Nat. Commun.
9
4582-4582
2018
1143918
Hanson A.J.,Wallace H.A.,Freeman T.J.,Beauchamp R.D.,Lee L.A.,Lee E.
XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling.
Mol. Cell
45
619-628
2012
1143919
Edison N.,Curtz Y.,Paland N.,Mamriev D.,Chorubczyk N.,Haviv-Reingewertz T.,Kfir N.,Morgenstern D.,Kupervaser M.,Kagan J.,Kim H.T.,Larisch S.
Degradation of Bcl-2 by XIAP and ARTS Promotes Apoptosis.
Cell Rep.
21
442-454
2017
1143920
Sun C.,Cai M.,Gunasekera A.H.,Meadows R.P.,Wang H.,Chen J.,Zhang H.,Wu W.,Xu N.,Ng S.-C.,Fesik S.W.
NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP.
Nature
401
818-822
1999
1143921
Liu Z.,Sun C.,Olejniczak E.T.,Meadows R.P.,Betz S.F.,Oost T.,Herrmann J.,Wu J.C.,Fesik S.W.
Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain.
Nature
408
1004-1008
2000
1143922
Huang Y.,Park Y.C.,Rich R.L.,Segal D.,Myszka D.G.,Wu H.
Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain.
Cell
104
781-790
2001
1143923
Shiozaki E.N.,Chai J.,Rigotti D.J.,Riedl S.J.,Li P.,Srinivasula S.M.,Alnemri E.S.,Fairman R.,Shi Y.
Mechanism of XIAP-mediated inhibition of caspase-9.
Mol. Cell
11
519-527
2003
1143924
Oost T.K.,Sun C.,Armstrong R.C.,Al-Assaad A.-S.,Betz S.F.,Deckwerth T.L.,Ding H.,Elmore S.W.,Meadows R.P.,Olejniczak E.T.,Oleksijew A.,Oltersdorf T.,Rosenberg S.H.,Shoemaker A.R.,Tomaselli K.J.,Zou H.,Fesik S.W.
Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
J. Med. Chem.
47
4417-4426
2004
1143925
Wist A.D.,Gu L.,Riedl S.J.,Shi Y.,McLendon G.L.
Structure-activity based study of the Smac-binding pocket within the BIR3 domain of XIAP.
Bioorg. Med. Chem.
15
2935-2943
2007
1143926
Lin S.-C.,Huang Y.,Lo Y.-C.,Lu M.,Wu H.
Crystal structure of the BIR1 domain of XIAP in two crystal forms.
J. Mol. Biol.
372
847-854
2007
1143927
Lu M.,Lin S.-C.,Huang Y.,Kang Y.J.,Rich R.,Lo Y.-C.,Myszka D.,Han J.,Wu H.
XIAP induces NF-kappaB activation via the BIR1/TAB1 interaction and BIR1 dimerization.
Mol. Cell
26
689-702
2007