Sequence of ATS13_HUMAN

ADAMTS13 endopeptidase

Q76LX8

1427

153604

9241

Soejima K.,Mimura N.,Hirashima M.,Maeda H.,Hamamoto T.,Nakagaki T.,Nozaki C.

A novel human metalloprotease synthesized in the liver and secreted into the blood: possibly, the von Willebrand factor-cleaving protease?

J. Biochem.

130

475-480

2001

9242

Zheng X.,Chung D.,Takayama T.K.,Majerus E.M.,Sadler J.E.,Fujikawa K.

Structure of von Willebrand factor-cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura.

J. Biol. Chem.

276

41059-41063

2001

9243

Levy G.G.,Nichols W.C.,Lian E.C.,Foroud T.,McClintick J.N.,McGee B.M.,Yang A.Y.,Siemieniak D.R.,Stark K.R.,Gruppo R.,Sarode R.,Shurin S.B.,Chandrasekaran V.,Stabler S.P.,Sabio H.,Bouhassira E.E.,Upshaw J.D. Jr.,Ginsburg D.,Tsai H.-M.

Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura.

Nature

413

488-494

2001

9244

Cal S.,Obaya A.J.,Llamazares M.,Garabaya C.,Quesada V.,Lopez-Otin C.

Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains.

Gene

283

49-62

2002

9247

Humphray S.J.,Oliver K.,Hunt A.R.,Plumb R.W.,Loveland J.E.,Howe K.L.,Andrews T.D.,Searle S.,Hunt S.E.,Scott C.E.,Jones M.C.,Ainscough R.,Almeida J.P.,Ambrose K.D.,Ashwell R.I.S.,Babbage A.K.,Babbage S.,Bagguley C.L.,Bailey J.,Banerjee R.,Barker D.J.,Barlow K.F.,Bates K.,Beasley H.,Beasley O.,Bird C.P.,Bray-Allen S.,Brown A.J.,Brown J.Y.,Burford D.,Burrill W.,Burton J.,Carder C.,Carter N.P.,Chapman J.C.,Chen Y.,Clarke G.,Clark S.Y.,Clee C.M.,Clegg S.,Collier R.E.,Corby N.,Crosier M.,Cummings A.T.,Davies J.,Dhami P.,Dunn M.,Dutta I.,Dyer L.W.,Earthrowl M.E.,Faulkner L.,Fleming C.J.,Frankish A.,Frankland J.A.,French L.,Fricker D.G.,Garner P.,Garnett J.,Ghori J.,Gilbert J.G.R.,Glison C.,Grafham D.V.,Gribble S.,Griffiths C.,Griffiths-Jones S.,Grocock R.,Guy J.,Hall R.E.,Hammond S.,Harley J.L.,Harrison E.S.I.,Hart E.A.,Heath P.D.,Henderson C.D.,Hopkins B.L.,Howard P.J.,Howden P.J.,Huckle E.,Johnson C.,Johnson D.,Joy A.A.,Kay M.,Keenan S.,Kershaw J.K.,Kimberley A.M.,King A.,Knights A.,Laird G.K.,Langford C.,Lawlor S.,Leongamornlert D.A.,Leversha M.,Lloyd C.,Lloyd D.M.,Lovell J.,Martin S.,Mashreghi-Mohammadi M.,Matthews L.,McLaren S.,McLay K.E.,McMurray A.,Milne S.,Nickerson T.,Nisbett J.,Nordsiek G.,Pearce A.V.,Peck A.I.,Porter K.M.,Pandian R.,Pelan S.,Phillimore B.,Povey S.,Ramsey Y.,Rand V.,Scharfe M.,Sehra H.K.,Shownkeen R.,Sims S.K.,Skuce C.D.,Smith M.,Steward C.A.,Swarbreck D.,Sycamore N.,Tester J.,Thorpe A.,Tracey A.,Tromans A.,Thomas D.W.,Wall M.,Wallis J.M.,West A.P.,Whitehead S.L.,Willey D.L.,Williams S.A.,Wilming L.,Wray P.W.,Young L.,Ashurst J.L.,Coulson A.,Blocker H.,Durbin R.M.,Sulston J.E.,Hubbard T.,Jackson M.J.,Bentley D.R.,Beck S.,Rogers J.,Dunham I.

DNA sequence and analysis of human chromosome 9.

Nature

429

369-374

2004

9249

Clark H.F.,Gurney A.L.,Abaya E.,Baker K.,Baldwin D.T.,Brush J.,Chen J.,Chow B.,Chui C.,Crowley C.,Currell B.,Deuel B.,Dowd P.,Eaton D.,Foster J.S.,Grimaldi C.,Gu Q.,Hass P.E.,Heldens S.,Huang A.,Kim H.S.,Klimowski L.,Jin Y.,Johnson S.,Lee J.,Lewis L.,Liao D.,Mark M.R.,Robbie E.,Sanchez C.,Schoenfeld J.,Seshagiri S.,Simmons L.,Singh J.,Smith V.,Stinson J.,Vagts A.,Vandlen R.L.,Watanabe C.,Wieand D.,Woods K.,Xie M.-H.,Yansura D.G.,Yi S.,Yu G.,Yuan J.,Zhang M.,Zhang Z.,Goddard A.D.,Wood W.I.,Godowski P.J.,Gray A.M.

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

Genome Res.

13

2265-2270

2003

9250

Wiemann S.,Weil B.,Wellenreuther R.,Gassenhuber J.,Glassl S.,Ansorge W.,Boecher M.,Bloecker H.,Bauersachs S.,Blum H.,Lauber J.,Duesterhoeft A.,Beyer A.,Koehrer K.,Strack N.,Mewes H.-W.,Ottenwaelder B.,Obermaier B.,Tampe J.,Heubner D.,Wambutt R.,Korn B.,Klein M.,Poustka A.

Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

Genome Res.

11

422-435

2001

9251

Gerritsen H.E.,Robles R.,Laemmle B.,Furlan M.

Partial amino acid sequence of purified von Willebrand factor-cleaving protease.

Blood

98

1654-1661

2001

9252

Fujikawa K.,Suzuki H.,McMullen B.,Chung D.

Purification of human von Willebrand factor-cleaving protease and its identification as a new member of the metalloproteinase family.

Blood

98

1662-1666

2001

9253

Zheng X.,Nishio K.,Majerus E.M.,Sadler J.E.

Cleavage of von Willebrand factor requires the spacer domain of the metalloprotease ADAMTS13.

J. Biol. Chem.

278

30136-30141

2003

9254

Majerus E.M.,Zheng X.,Tuley E.A.,Sadler J.E.

Cleavage of the ADAMTS13 propeptide is not required for protease activity.

J. Biol. Chem.

278

46643-46648

2003

9255

Liu T.,Qian W.-J.,Gritsenko M.A.,Camp D.G. II,Monroe M.E.,Moore R.J.,Smith R.D.

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

J. Proteome Res.

4

2070-2080

2005

9256

Anderson P.J.,Kokame K.,Sadler J.E.

Zinc and calcium ions cooperatively modulate ADAMTS13 activity.

J. Biol. Chem.

281

850-857

2006

9257

Ricketts L.M.,Dlugosz M.,Luther K.B.,Haltiwanger R.S.,Majerus E.M.

O-fucosylation is required for ADAMTS13 secretion.

J. Biol. Chem.

282

17014-17023

2007

9258

Gardner M.D.,Chion C.K.,de Groot R.,Shah A.,Crawley J.T.,Lane D.A.

A functional calcium-binding site in the metalloprotease domain of ADAMTS13.

Blood

113

1149-1157

2009

9259

Jia W.,Lu Z.,Fu Y.,Wang H.P.,Wang L.H.,Chi H.,Yuan Z.F.,Zheng Z.B.,Song L.N.,Han H.H.,Liang Y.M.,Wang J.L.,Cai Y.,Zhang Y.K.,Deng Y.L.,Ying W.T.,He S.M.,Qian X.H.

A strategy for precise and large scale identification of core fucosylated glycoproteins.

Mol. Cell. Proteomics

8

913-923

2009

9260

Lotta L.A.,Garagiola I.,Palla R.,Cairo A.,Peyvandi F.

ADAMTS13 mutations and polymorphisms in congenital thrombotic thrombocytopenic purpura.

Hum. Mutat.

31

11-19

2010

9261

Akiyama M.,Takeda S.,Kokame K.,Takagi J.,Miyata T.

Crystal structures of the noncatalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor.

Proc. Natl. Acad. Sci. U.S.A.

106

19274-19279

2009

9262

Kokame K.,Matsumoto M.,Soejima K.,Yagi H.,Ishizashi H.,Funato M.,Tamai H.,Konno M.,Kamide K.,Kawano Y.,Miyata T.,Fujimura Y.

Mutations and common polymorphisms in ADAMTS13 gene responsible for von Willebrand factor-cleaving protease activity.

Proc. Natl. Acad. Sci. U.S.A.

99

11902-11907

2002

9263

Schneppenheim R.,Budde U.,Oyen F.,Angerhaus D.,Aumann V.,Drewke E.,Hassenpflug W.,Haberle J.,Kentouche K.,Kohne E.,Kurnik K.,Mueller-Wiefel D.,Obser T.,Santer R.,Sykora K.W.

von Willebrand factor cleaving protease and ADAMTS13 mutations in childhood TTP.

Blood

101

1845-1850

2003

9264

Antoine G.,Zimmermann K.,Plaimauer B.,Grillowitzer M.,Studt J.D.,Lammle B.,Scheiflinger F.

ADAMTS13 gene defects in two brothers with constitutional thrombotic thrombocytopenic purpura and normalization of von Willebrand factor-cleaving protease activity by recombinant human ADAMTS13.

Br. J. Haematol.

120

821-824

2003

9265

Assink K.,Schiphorst R.,Allford S.,Karpman D.,Etzioni A.,Brichard B.,van de Kar N.,Monnens L.,van den Heuvel L.

Mutation analysis and clinical implications of von Willebrand factor-cleaving protease deficiency.

Kidney Int.

63

1995-1999

2003

9266

Pimanda J.E.,Maekawa A.,Wind T.,Paxton J.,Chesterman C.N.,Hogg P.J.

Congenital thrombotic thrombocytopenic purpura in association with a mutation in the second CUB domain of ADAMTS13.

Blood

103

627-629

2004

9267

Matsumoto M.,Kokame K.,Soejima K.,Miura M.,Hayashi S.,Fujii Y.,Iwai A.,Ito E.,Tsuji Y.,Takeda-Shitaka M.,Iwadate M.,Umeyama H.,Yagi H.,Ishizashi H.,Banno F.,Nakagaki T.,Miyata T.,Fujimura Y.

Molecular characterization of ADAMTS13 gene mutations in Japanese patients with Upshaw-Schulman syndrome.

Blood

103

1305-1310

2004

9268

Uchida T.,Wada H.,Mizutani M.,Iwashita M.,Ishihara H.,Shibano T.,Suzuki M.,Matsubara Y.,Soejima K.,Matsumoto M.,Fujimura Y.,Ikeda Y.,Murata M.

Identification of novel mutations in ADAMTS13 in an adult patient with congenital thrombotic thrombocytopenic purpura.

Blood

104

2081-2083

2004

9269

Veyradier A.,Lavergne J.M.,Ribba A.S.,Obert B.,Loirat C.,Meyer D.,Girma J.P.

Ten candidate ADAMTS13 mutations in six French families with congenital thrombotic thrombocytopenic purpura (Upshaw-Schulman syndrome).

J. Thromb. Haemost.

2

424-429

2004

9270

Licht C.,Stapenhorst L.,Simon T.,Budde U.,Schneppenheim R.,Hoppe B.

Two novel ADAMTS13 gene mutations in thrombotic thrombocytopenic purpura/hemolytic-uremic syndrome (TTP/HUS).

Kidney Int.

66

955-958

2004

9271

Liu F.,Jin J.,Dong N.Z.,Wang Y.G.,Ruan C.G.

Identification of two novel mutations in ADAMTS13 gene in a patient with hereditary thrombotic thrombocytopenic purpura.

Zhonghua Xue Ye Xue Za Zhi

26

521-524

2005

9272

Plaimauer B.,Fuhrmann J.,Mohr G.,Wernhart W.,Bruno K.,Ferrari S.,Konetschny C.,Antoine G.,Rieger M.,Scheiflinger F.

Modulation of ADAMTS13 secretion and specific activity by a combination of common amino acid polymorphisms and a missense mutation.

Blood

107

118-125

2006

9273

Peyvandi F.,Lavoretano S.,Palla R.,Valsecchi C.,Merati G.,De Cristofaro R.,Rossi E.,Mannuccio Mannucci P.

Mechanisms of the interaction between two ADAMTS13 gene mutations leading to severe deficiency of enzymatic activity.

Hum. Mutat.

27

330-336

2006

9274

Tao Z.,Anthony K.,Peng Y.,Choi H.,Nolasco L.,Rice L.,Moake J.L.,Dong J.F.

Novel ADAMTS-13 mutations in an adult with delayed onset thrombotic thrombocytopenic purpura.

J. Thromb. Haemost.

4

1931-1935

2006

9275

Shibagaki Y.,Matsumoto M.,Kokame K.,Ohba S.,Miyata T.,Fujimura Y.,Fujita T.

Novel compound heterozygote mutations (H234Q/R1206X) of the ADAMTS13 gene in an adult patient with Upshaw-Schulman syndrome showing predominant episodes of repeated acute renal failure.

Nephrol. Dial. Transplant.

21

1289-1292

2006

9276

Schneppenheim R.,Kremer Hovinga J.A.,Becker T.,Budde U.,Karpman D.,Brockhaus W.,Hrachovinova I.,Korczowski B.,Oyen F.,Rittich S.,von Rosen J.,Tjonnfjord G.E.,Pimanda J.E.,Wienker T.F.,Lammle B.

A common origin of the 4143insA ADAMTS13 mutation.

Thromb. Haemost.

96

3-6

2006

9277

Donadelli R.,Banterla F.,Galbusera M.,Capoferri C.,Bucchioni S.,Gastoldi S.,Nosari S.,Monteferrante G.,Ruggeri Z.M.,Bresin E.,Scheiflinger F.,Rossi E.,Martinez C.,Coppo R.,Remuzzi G.,Noris M.

In-vitro and in-vivo consequences of mutations in the von Willebrand factor cleaving protease ADAMTS13 in thrombotic thrombocytopenic purpura.

Thromb. Haemost.

96

454-464

2006

9278

Meyer S.C.,Jeddi R.,Meddeb B.,Gouider E.,Lammle B.,Kremer Hovinga J.A.

A first case of congenital TTP on the African continent due to a new homozygous mutation in the catalytic domain of ADAMTS13.

Ann. Hematol.

87

663-666

2008

9279

Fujimura Y.,Matsumoto M.,Kokame K.,Isonishi A.,Soejima K.,Akiyama N.,Tomiyama J.,Natori K.,Kuranishi Y.,Imamura Y.,Inoue N.,Higasa S.,Seike M.,Kozuka T.,Hara M.,Wada H.,Murata M.,Ikeda Y.,Miyata T.,George J.N.

Pregnancy-induced thrombocytopenia and TTP, and the risk of fetal death, in Upshaw-Schulman syndrome: a series of 15 pregnancies in 9 genotyped patients.

Br. J. Haematol.

144

742-754

2009

9280

Palla R.,Lavoretano S.,Lombardi R.,Garagiola I.,Karimi M.,Afrasiabi A.,Ramzi M.,De Cristofaro R.,Peyvandi F.

The first deletion mutation in the TSP1-6 repeat domain of ADAMTS13 in a family with inherited thrombotic thrombocytopenic purpura.

Haematologica

94

289-293

2009

9281

Lee S.H.,Park J.H.,Park S.K.,Lee E.H.,Choi J.I.,Visentin G.P.,Park T.S.,Oh S.H.,Kim S.R.

A novel homozygous missense ADAMTS13 mutation Y658C in a patient with recurrent thrombotic thrombocytopenic purpura.

Ann. Clin. Lab. Sci.

41

273-276

2011

9282

Choi H.S.,Cheong H.I.,Kim N.K.,Oh D.,Park H.W.

ADAMTS13 gene mutations in children with hemolytic uremic syndrome.

Yonsei Med. J.

52

530-534

2011