Sequence of HYAS2_HUMAN
EC Number:2.4.1.212
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-[nascent hyaluronan] = UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-[nascent hyaluronan]
Other sequences found for EC No. 2.4.1.212
General information:
Sequence
0 MHCERFLCIL RIIGTTLFGV SLLLGITAAY IVGYQFIQTD NYYFSFGLYG AFLASHLIIQ
60 SLFAFLEHRK MKKSLETPIK LNKTVALCIA AYQEDPDYLR KCLQSVKRLT YPGIKVVMVI
120 DGNSEDDLYM MDIFSEVMGR DKSATYIWKN NFHEKGPGET DESHKESSQH VTQLVLSNKS
180 ICIMQKWGGK REVMYTAFRA LGRSVDYVQV CDSDTMLDPA SSVEMVKVLE EDPMVGGVGG
240 DVQILNKYDS WISFLSSVRY WMAFNIERAC QSYFGCVQCI SGPLGMYRNS LLHEFVEDWY
300 NQEFMGNQCS FGDDRHLTNR VLSLGYATKY TARSKCLTET PIEYLRWLNQ QTRWSKSYFR
360 EWLYNAMWFH KHHLWMTYEA IITGFFPFFL IATVIQLFYR GKIWNILLFL LTVQLVGLIK
420 SSFASCLRGN IVMVFMSLYS VLYMSSLLPA KMFAIATINK AGWGTSGRKT IVVNFIGLIP
480 VSVWFTILLG GVIFTIYKES KRPFSESKQT VLIVGTLLYA CYWVMLLTLY VVLINKCGRR
540 KKGQQYDMVL DV
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1070954
Watanabe K.,Yamaguchi Y.
Molecular identification of a putative human hyaluronan synthase.
J. Biol. Chem.
271
22945-22948
1996
1070955
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
1070956
Morerio C.,Rapella A.,Rosanda C.,Tassano E.,Gambini C.,Romagnoli G.,Panarello C.
PLAG1-HAS2 fusion in lipoblastoma with masked 8q intrachromosomal rearrangement.
Cancer Genet. Cytogenet.
156
183-184
2005
1070957
Rilla K.,Oikari S.,Jokela T.A.,Hyttinen J.M.,Kaernae R.,Tammi R.H.,Tammi M.I.
Hyaluronan synthase 1 (HAS1) requires higher cellular UDP-GlcNAc concentration than HAS2 and HAS3.
J. Biol. Chem.
288
5973-5983
2013
1070958
Karousou E.,Kamiryo M.,Skandalis S.S.,Ruusala A.,Asteriou T.,Passi A.,Yamashita H.,Hellman U.,Heldin C.H.,Heldin P.
The activity of hyaluronan synthase 2 is regulated by dimerization and ubiquitination.
J. Biol. Chem.
285
23647-23654
2010
1070959
Vigetti D.,Clerici M.,Deleonibus S.,Karousou E.,Viola M.,Moretto P.,Heldin P.,Hascall V.C.,De Luca G.,Passi A.
Hyaluronan synthesis is inhibited by adenosine monophosphate-activated protein kinase through the regulation of HAS2 activity in human aortic smooth muscle cells.
J. Biol. Chem.
286
7917-7924
2011
1070960
Vigetti D.,Deleonibus S.,Moretto P.,Karousou E.,Viola M.,Bartolini B.,Hascall V.C.,Tammi M.,De Luca G.,Passi A.
Role of UDP-N-acetylglucosamine (GlcNAc) and O-GlcNAcylation of hyaluronan synthase 2 in the control of chondroitin sulfate and hyaluronan synthesis.
J. Biol. Chem.
287
35544-35555
2012
1070961
Bart G.,Vico N.O.,Hassinen A.,Pujol F.M.,Deen A.J.,Ruusala A.,Tammi R.H.,Squire A.,Heldin P.,Kellokumpu S.,Tammi M.I.
Fluorescence resonance energy transfer (FRET) and proximity ligation assays reveal functionally relevant homo- and heteromeric complexes among hyaluronan synthases HAS1, HAS2, and HAS3.
J. Biol. Chem.
290
11479-11490
2015
1070962
Mehic M.,de Sa V.K.,Hebestreit S.,Heldin C.H.,Heldin P.
The deubiquitinating enzymes USP4 and USP17 target hyaluronan synthase 2 and differentially affect its function.
Oncogenesis
6
0-0
2017
1070963
Melero-Fernandez de Mera R.M.,Arasu U.T.,Kaernae R.,Oikari S.,Rilla K.,Vigetti D.,Passi A.,Heldin P.,Tammi M.I.,Deen A.J.
Effects of mutations in the post-translational modification sites on the trafficking of hyaluronan synthase 2 (HAS2).
Matrix Biol.
80
85-103
2019
1070964
Kasai K.,Kuroda Y.,Takabuchi Y.,Nitta A.,Kobayashi T.,Nozaka H.,Miura T.,Nakamura T.
Phosphorylation of Thr328 in hyaluronan synthase 2 is essential for hyaluronan synthesis.
Biochem. Biophys. Res. Commun.
533
732-738
2020
