Sequence of FAS2_YEAST
EC Number:2.3.1.86
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
fatty-acyl-CoA synthase system
P19097
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
1887
206947
Reaction
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoyl-CoA + 7 CoA + 7 CO2 + 14 NADP+ + 7 H2O
Other sequences found for EC No. 2.3.1.86
General information:
Sequence
0 MKPEVEQELA HILLTELLAY QFASPVRWIE TQDVFLKDFN TERVVEIGPS PTLAGMAQRT
60 LKNKYESYDA ALSLHREILC YSKDAKEIYY TPDPSELAAK EEPAKEEAPA PTPAASAPAP
120 AAAAPAPVAA AAPAAAAAEI ADEPVKASLL LHVLVAHKLK KSLDSIPMSK TIKDLVGGKS
180 TVQNEILGDL GKEFGTTPEK PEETPLEELA ETFQDTFSGA LGKQSSSLLS RLISSKMPGG
240 FTITVARKYL QTRWGLPSGR QDGVLLVALS NEPAARLGSE ADAKAFLDSM AQKYASIVGV
300 DLSSAASASG AAGAGAAAGA AMIDAGALEE ITKDHKVLAR QQLQVLARYL KMDLDNGERK
360 FLKEKDTVAE LQAQLDYLNA ELGEFFVNGV ATSFSRKKAR TFDSSWNWAK QSLLSLYFEI
420 IHGVLKNVDR EVVSEAINIM NRSNDALIKF MEYHISNTDE TKGENYQLVK TLGEQLIENC
480 KQVLDVDPVY KDVAKPTGPK TAIDKNGNIT YSEEPREKVR KLSQYVQEMA LGGPITKESQ
540 PTIEEDLTRV YKAISAQADK QDISSSTRVE FEKLYSDLMK FLESSKEIDP SQTTQLAGMD
600 VEDALDKDST KEVASLPNKS TISKTVSSTI PRETIPFLHL RKKTPAGDWK YDRQLSSLFL
660 DGLEKAAFNG VTFKDKYVLI TGAGKGSIGA EVLQGLLQGG AKVVVTTSRF SKQVTDYYQS
720 IYAKYGAKGS TLIVVPFNQG SKQDVEALIE FIYDTEKNGG LGWDLDAIIP FAAIPEQGIE
780 LEHIDSKSEF AHRIMLTNIL RMMGCVKKQK SARGIETRPA QVILPMSPNH GTFGGDGMYS
840 ESKLSLETLF NRWHSESWAN QLTVCGAIIG WTRGTGLMSA NNIIAEGIEK MGVRTFSQKE
900 MAFNLLGLLT PEVVELCQKS PVMADLNGGL QFVPELKEFT AKLRKELVET SEVRKAVSIE
960 TALEHKVVNG NSADAAYAQV EIQPRANIQL DFPELKPYKQ VKQIAPAELE GLLDLERVIV
1020 VTGFAEVGPW GSARTRWEME AFGEFSLEGC VEMAWIMGFI SYHNGNLKGR PYTGWVDSKT
1080 KEPVDDKDVK AKYETSILEH SGIRLIEPEL FNGYNPEKKE MIQEVIVEED LEPFEASKET
1140 AEQFKHQHGD KVDIFEIPET GEYSVKLLKG ATLYIPKALR FDRLVAGQIP TGWNAKTYGI
1200 SDDIISQVDP ITLFVLVSVV EAFIASGITD PYEMYKYVHV SEVGNCSGSG MGGVSALRGM
1260 FKDRFKDEPV QNDILQESFI NTMSAWVNML LISSSGPIKT PVGACATSVE SVDIGVETIL
1320 SGKARICIVG GYDDFQEEGS FEFGNMKATS NTLEEFEHGR TPAEMSRPAT TTRNGFMEAQ
1380 GAGIQIIMQA DLALKMGVPI YGIVAMAATA TDKIGRSVPA PGKGILTTAR EHHSSVKYAS
1440 PNLNMKYRKR QLVTREAQIK DWVENELEAL KLEAEEIPSE DQNEFLLERT REIHNEAESQ
1500 LRAAQQQWGN DFYKRDPRIA PLRGALATYG LTIDDLGVAS FHGTSTKAND KNESATINEM
1560 MKHLGRSEGN PVIGVFQKFL TGHPKGAAGA WMMNGALQIL NSGIIPGNRN ADNVDKILEQ
1620 FEYVLYPSKT LKTDGVRAVS ITSFGFGQKG GQAIVVHPDY LYGAITEDRY NEYVAKVSAR
1680 EKSAYKFFHN GMIYNKLFVS KEHAPYTDEL EEDVYLDPLA RVSKDKKSGS LTFNSKNIQS
1740 KDSYINANTI ETAKMIENMT KEKVSNGGVG VDVELITSIN VENDTFIERN FTPQEIEYCS
1800 AQPSVQSSFA GTWSAKEAVF KSLGVKSLGG GAALKDIEIV RVNKNAPAVE LHGNAKKAAE
1860 EAGVTDVKVS ISHDDLQAVA VAVSTKK
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1057407
Mohamed A.H.,Chirala S.S.,Mody N.H.,Huang W.Y.,Wakil S.J.
Primary structure of the multifunctional alpha subunit protein of yeast fatty acid synthase derived from FAS2 gene sequence.
J. Biol. Chem.
263
12315-12325
1988
1057409
Bussey H.,Storms R.K.,Ahmed A.,Albermann K.,Allen E.,Ansorge W.,Araujo R.,Aparicio A.,Barrell B.G.,Badcock K.,Benes V.,Botstein D.,Bowman S.,Brueckner M.,Carpenter J.,Cherry J.M.,Chung E.,Churcher C.M.,Coster F.,Davis K.,Davis R.W.,Dietrich F.S.,Delius H.,DiPaolo T.,Dubois E.,Duesterhoeft A.,Duncan M.,Floeth M.,Fortin N.,Friesen J.D.,Fritz C.,Goffeau A.,Hall J.,Hebling U.,Heumann K.,Hilbert H.,Hillier L.W.,Hunicke-Smith S.,Hyman R.W.,Johnston M.,Kalman S.,Kleine K.,Komp C.,Kurdi O.,Lashkari D.,Lew H.,Lin A.,Lin D.,Louis E.J.,Marathe R.,Messenguy F.,Mewes H.-W.,Mirtipati S.,Moestl D.,Mueller-Auer S.,Namath A.,Nentwich U.,Oefner P.,Pearson D.,Petel F.X.,Pohl T.M.,Purnelle B.,Rajandream M.A.,Rechmann S.,Rieger M.,Riles L.,Roberts D.,Schaefer M.,Scharfe M.,Scherens B.,Schramm S.,Schroeder M.,Sdicu A.-M.,Tettelin H.,Urrestarazu L.A.,Ushinsky S.,Vierendeels F.,Vissers S.,Voss H.,Walsh S.V.,Wambutt R.,Wang Y.,Wedler E.,Wedler H.,Winnett E.,Zhong W.-W.,Zollner A.,Vo D.H.,Hani J.
The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.
Nature
387
103-105
1997
1057410
Engel S.R.,Dietrich F.S.,Fisk D.G.,Binkley G.,Balakrishnan R.,Costanzo M.C.,Dwight S.S.,Hitz B.C.,Karra K.,Nash R.S.,Weng S.,Wong E.D.,Lloyd P.,Skrzypek M.S.,Miyasato S.R.,Simison M.,Cherry J.M.
The reference genome sequence of Saccharomyces cerevisiae: Then and now.
G3 (Bethesda)
4
389-398
2014
1057411
Inokoshi J.,Tomoda H.,Hashimoto H.,Watanabe A.,Takeshima H.,Omura S.
Cerulenin-resistant mutants of Saccharomyces cerevisiae with an altered fatty acid synthase gene.
Mol. Gen. Genet.
244
90-96
1994
1057412
Ghaemmaghami S.,Huh W.-K.,Bower K.,Howson R.W.,Belle A.,Dephoure N.,O'Shea E.K.,Weissman J.S.
Global analysis of protein expression in yeast.
Nature
425
737-741
2003
1057413
Gruhler A.,Olsen J.V.,Mohammed S.,Mortensen P.,Faergeman N.J.,Mann M.,Jensen O.N.
Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.
Mol. Cell. Proteomics
4
310-327
2005
1057414
Li X.,Gerber S.A.,Rudner A.D.,Beausoleil S.A.,Haas W.,Villen J.,Elias J.E.,Gygi S.P.
Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.
J. Proteome Res.
6
1190-1197
2007
1057415
Reinders J.,Wagner K.,Zahedi R.P.,Stojanovski D.,Eyrich B.,van der Laan M.,Rehling P.,Sickmann A.,Pfanner N.,Meisinger C.
Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase.
Mol. Cell. Proteomics
6
1896-1906
2007
1057416
Albuquerque C.P.,Smolka M.B.,Payne S.H.,Bafna V.,Eng J.,Zhou H.
A multidimensional chromatography technology for in-depth phosphoproteome analysis.
Mol. Cell. Proteomics
7
1389-1396
2008
1057417
Holt L.J.,Tuch B.B.,Villen J.,Johnson A.D.,Gygi S.P.,Morgan D.O.
Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.
Science
325
1682-1686
2009
1057418
Starita L.M.,Lo R.S.,Eng J.K.,von Haller P.D.,Fields S.
Sites of ubiquitin attachment in Saccharomyces cerevisiae.
Proteomics
12
236-240
2012
1057419
Lomakin I.B.,Xiong Y.,Steitz T.A.
The crystal structure of yeast fatty acid synthase, a cellular machine with eight active sites working together.
Cell
129
319-332
2007
1057420
Leibundgut M.,Jenni S.,Frick C.,Ban N.
Structural basis for substrate delivery by acyl carrier protein in the yeast fatty acid synthase.
Science
316
288-290
2007
1057421
Johansson P.,Wiltschi B.,Kumari P.,Kessler B.,Vonrhein C.,Vonck J.,Oesterhelt D.,Grininger M.
Inhibition of the fungal fatty acid synthase type I multienzyme complex.
Proc. Natl. Acad. Sci. U.S.A.
105
12803-12808
2008
1057422
Johansson P.,Mulinacci B.,Koestler C.,Vollrath R.,Oesterhelt D.,Grininger M.
Multimeric options for the auto-activation of the Saccharomyces cerevisiae FAS type I megasynthase.
Structure
17
1063-1074
2009
