Sequence of ATX_ASPTN
EC Number:2.3.1.165
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
6-methylsalicylic-acid synthase
Q0CJ59
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
1803
193794
Reaction
acetyl-CoA + 3 malonyl-CoA + NADPH + H+ = 6-methylsalicylate + 4 CoA + 3 CO2 + NADP+ + H2O
Other sequences found for EC No. 2.3.1.165
General information:
Sequence
0 MEVHGDEVLS VDSGVSTPPS TGSGFRRPLE TPGTEIGNLN LNPQNEVAVV GMACRLAGGN
60 NSPEELWQSI LNRKDASGEI PSMRWEPYYR RDIRNPKILD QTTKRGYFLD HVENFDAAFF
120 GVSPKEAEQM DPQQRLSLEV TWEALEDAGI PPQSLSGSET AVFMGVNSDD YSKLLLEDIP
180 NVEAWMGIGT AYCGVPNRIS YHLNLMGPST AVDAACASSL VAIHHGRQAI LQGESEVAIV
240 GGVNALCGPG LTRVLDKAGA TSTEGRCLSF DEDAKGYGRG EGAAVVILKR LSTAIRDGDH
300 IRAIIKGSAV AQDGKTNGIM APNAKAQELV AWNALRTAGV DPLTVGYVEA HATSTPLGDP
360 TEVSAVSAVY GKGRPEGNPC FIGSVKPNVG HLEAGAGAVG FIKAVMAVEK AIFPPQTNLK
420 RLNSRIDWGQ AGVKVVQETL EWPGNEDDVR RAGVCSYGYG GTVSHAIIEE FAQQLQRPTT
480 NTTDEDPLPR ILLLSAPQER RLALQARTQA SWIAAEGRNR TLESIATTLS TRRGHHDYRA
540 AIIAENHDDA VQKLSDIVNG KAAEWTTSSR VLDASCSKDV VWVFSGHGAQ WTAMATDLLK
600 DIVFYQTISR LDPIVEREMG FSALHSLASG DFESSIKVQV LTYLVQVGLA AILRSKGLEP
660 QAVIGHSVGE IAASVAAGCL TAEEGALIVT RRANLYRRVM GAGAMVLVNI PFVDMEKELQ
720 GRTDLVAAID SSPSSCVVSG ATEAVLALVE DLKSRGVNAF RVKTDIPFHH PMLDQLSEPL
780 REAMAGSLSP RKPRVRLYST SAEDPRSMVA RDIYYWTSNM VNPVRLTAAV QAAVDDGLRL
840 FLEVSSHPIV SHSVRETMLD LGVEDFTVTN TMARNKPADK TILSSIAQLH CRGAVVNWKK
900 QLPGPWALDV PLTTWDHKPY WRHIHTGPIS ASTLHDVDKH TLLGQRVPVA GETTMVFTTQ
960 MDDQTKPFPG SHPLHGSEIV PAAALVNTFL HATGATTLSN ITLRVPVAIS QPRDIQVVVS
1020 QNQIKICSRL TQKAGSGADE GSWLTHTTGQ WEAGGSKNAP AQLDIAAIKA RLANNKLADN
1080 FSIDYLDKVG VSAMGFPWAV TEHYGTLQEM IARVDVAPDV PATSPLPWDA ASWAPILDAA
1140 TSVGSTLFFD QPRLRMPAHI HGVQVYTTQP PLKVGYLYVE KAGDRDLAVH VSVCDELGTV
1200 LARFESMRFS EIEGTPGSNG SEESLVHQLA WPPAIYSEKP LTINNVVLVS RDKNVADLYC
1260 GSLKDRVSSI TVLDAAADLL SLSQDSSSVL QAKDTAVVYV PGPLHSADSI PTAAHSFLME
1320 LLLLVKIIVN GSLPTKVFVL TDRVCESESA TALAQSPIHG VSRIIAAEHP DQWGGLIDVE
1380 TPGQFPLETM KYVQEADNIR ISDGIPRIAR LRPLPRDKLL PPSKQTSLLP RPESTYLITG
1440 GLGALGLEVA QFLVEKGARR LILVSRRALP PRREWADILA DASSSLAPAL ETIQALEAQG
1500 ATVHTLAVDI SSPDAAPQLA VAIDSLSLPP VRGVVHAAGV LDSQLVLSAT SDSVERVLAP
1560 KITGALVLGT VFPPKALDFF MLFSSCGQLL GFPGQASYAS GNAFLDAFAT SRRHQGDNAV
1620 AVQWTSWRSL GMAASTDFIN AELASKGITD ITRDEGFRAW MHISKYDIDQ AAVLRSLAFE
1680 ADEPLPTPIL TDIAVRKAGS ASSADAPSAA PKETNEMPES IPERRTWLDE RIRDCVARVL
1740 QLGSSDEVDS KAALSDLGVD SVMTVSLRGQ LQKTLGVKVP PTLTWSCPTV SHLVGWFLEK
1800 MGN
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1033256
Fujii I.,Ono Y.,Tada H.,Gomi K.,Ebizuka Y.,Sankawa U.
Cloning of the polyketide synthase gene atX from Aspergillus terreus and its identification as the 6-methylsalicylic acid synthase gene by heterologous expression.
Mol. Gen. Genet.
253
1-10
1996
1033257
Pazoutova S.,Linka M.,Storkova S.,Schwab H.
Polyketide synthase gene pksM from Aspergillus terreus expressed during growth phase.
Folia Microbiol. (Praha)
42
419-430
1997
1033258
Kawakami Y.,Hartman S.E.,Kinoshita E.,Suzuki H.,Kitaura J.,Yao L.,Inagaki N.,Franco A.,Hata D.,Maeda-Yamamoto M.,Fukamachi H.,Nagai H.,Kawakami T.
Terreic acid, a quinone epoxide inhibitor of Bruton's tyrosine kinase.
Proc. Natl. Acad. Sci. U.S.A.
96
2227-2232
1999
1033259
Olesen S.H.,Ingles D.J.,Yang Y.,Schoenbrunn E.
Differential antibacterial properties of the MurA inhibitors terreic acid and fosfomycin.
J. Basic Microbiol.
54
322-326
2014
1033260
Boruta T.,Bizukojc M.
Culture-based and sequence-based insights into biosynthesis of secondary metabolites by Aspergillus terreus ATCC 20542.
J. Biotechnol.
175
53-62
2014
1033261
Guo C.J.,Sun W.W.,Bruno K.S.,Wang C.C.
Molecular genetic characterization of terreic acid pathway in Aspergillus terreus.
Org. Lett.
16
5250-5253
2014
