Sequence of UL97_HCMVA
EC Number:2.7.11.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
non-specific serine/threonine protein kinase
P16788
Human cytomegalovirus (strain AD169)
707
78233
Reaction
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate
Other sequences found for EC No. 2.7.11.1
General information:
Sequence
0 MSSALRSRAR SASLGTTTQG WDPPPLRRPS RARRRQWMRE AAQAAAQAAV QAAQAAAAQV
60 AQAHVDENEV VDLMADEAGG GVTTLTTLSS VSTTTVLGHA TFSACVRSDV MRDGEKEDAA
120 SDKENLRRPV VPSTSSRGSA ASGDGYHGLR CRETSAMWSF EYDRDGDVTS VRRALFTGGS
180 DPSDSVSGVR GGRKRPLRPP LVSLARTPLC RRRVGGVDAV LEENDVELRA ESQDSAVASG
240 PGRIPQPLSG SSGEESATAV EADSTSHDDV HCTCSNDQII TTSIRGLTCD PRMFLRLTHP
300 ELCELSISYL LVYVPKEDDF CHKICYAVDM SDESYRLGQG SFGEVWPLDR YRVVKVARKH
360 SETVLTVWMS GLIRTRAAGE QQQPPSLVGT GVHRGLLTAT GCCLLHNVTV HRRFHTDMFH
420 HDQWKLACID SYRRAFCTLA DAIKFLNHQC RVCHFDITPM NVLIDVNPHN PSEIVRAALC
480 DYSLSEPYPD YNERCVAVFQ ETGTARRIPN CSHRLRECYH PAFRPMPLQK LLICDPHARF
540 PVAGLRRYCM SELSALGNVL GFCLMRLLDR RGLDEVRMGT EALLFKHAGA ACRALENGKL
600 THCSDACLLI LAAQMSYGAC LLGEHGAALV SHTLRFVEAK MSSCRVRAFR RFYHECSQTM
660 LHEYVRKNVE RLLATSDGLY LYNAFRRTTS IICEEDLDGD CRQLFPE
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1011920
Chee M.S.,Bankier A.T.,Beck S.,Bohni R.,Brown C.M.,Cerny R.,Horsnell T.,Hutchison C.A. III,Kouzarides T.,Martignetti J.A.,Preddie E.,Satchwell S.C.,Tomlinson P.,Weston K.M.,Barrell B.G.
Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169.
Curr. Top. Microbiol. Immunol.
154
125-169
1990
1011921
Lurain N.S.,Weinberg A.,Crumpacker C.S.,Chou S.
Sequencing of cytomegalovirus UL97 gene for genotypic antiviral resistance testing.
Antimicrob. Agents Chemother.
45
2775-2780
2001
1011922
Davison A.J.,Dolan A.,Akter P.,Addison C.,Dargan D.J.,Alcendor D.J.,McGeoch D.J.,Hayward G.S.
The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genome.
J. Gen. Virol.
84
17-28
2003
1011924
Littler E.,Stuart A.D.,Chee M.S.
Human cytomegalovirus UL97 open reading frame encodes a protein that phosphorylates the antiviral nucleoside analogue ganciclovir.
Nature
358
160-162
1992
1011925
Sullivan V.,Talarico C.L.,Stanat S.C.,Davis M.,Coen D.M.,Biron K.K.
A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells.
Nature
358
162-164
1992
1011928
He Z.,He Y.S.,Kim Y.,Chu L.,Ohmstede C.,Biron K.K.,Coen D.M.
The human cytomegalovirus UL97 protein is a protein kinase that autophosphorylates on serines and threonines.
J. Virol.
71
405-411
1997
1011929
Kawaguchi Y.,Matsumura T.,Roizman B.,Hirai K.
Cellular elongation factor 1delta is modified in cells infected with representative alpha-, beta-, or gammaherpesviruses.
J. Virol.
73
4456-4460
1999
1011930
Baek M.C.,Krosky P.M.,He Z.,Coen D.M.
Specific phosphorylation of exogenous protein and peptide substrates by the human cytomegalovirus UL97 protein kinase. Importance of the P+5 position.
J. Biol. Chem.
277
29593-29599
2002
1011931
Krosky P.M.,Baek M.C.,Coen D.M.
The human cytomegalovirus UL97 protein kinase, an antiviral drug target, is required at the stage of nuclear egress.
J. Virol.
77
905-914
2003
1011932
Krosky P.M.,Baek M.C.,Jahng W.J.,Barrera I.,Harvey R.J.,Biron K.K.,Coen D.M.,Sethna P.B.
The human cytomegalovirus UL44 protein is a substrate for the UL97 protein kinase.
J. Virol.
77
7720-7727
2003
1011933
Varnum S.M.,Streblow D.N.,Monroe M.E.,Smith P.,Auberry K.J.,Pasa-Tolic L.,Wang D.,Camp D.G. II,Rodland K.,Wiley S.,Britt W.,Shenk T.,Smith R.D.,Nelson J.A.
Identification of proteins in human cytomegalovirus (HCMV) particles: the HCMV proteome.
J. Virol.
78
10960-10966
2004
1011935
Baek M.C.,Krosky P.M.,Pearson A.,Coen D.M.
Phosphorylation of the RNA polymerase II carboxyl-terminal domain in human cytomegalovirus-infected cells and in vitro by the viral UL97 protein kinase.
Virology
324
184-193
2004
1011936
Prichard M.N.,Britt W.J.,Daily S.L.,Hartline C.B.,Kern E.R.
Human cytomegalovirus UL97 Kinase is required for the normal intranuclear distribution of pp65 and virion morphogenesis.
J. Virol.
79
15494-15502
2005
1011937
Kamil J.P.,Coen D.M.
Human cytomegalovirus protein kinase UL97 forms a complex with the tegument phosphoprotein pp65.
J. Virol.
81
10659-10668
2007
1011938
Hume A.J.,Finkel J.S.,Kamil J.P.,Coen D.M.,Culbertson M.R.,Kalejta R.F.
Phosphorylation of retinoblastoma protein by viral protein with cyclin-dependent kinase function.
Science
320
797-799
2008
1011939
Goldberg M.D.,Honigman A.,Weinstein J.,Chou S.,Taraboulos A.,Rouvinski A.,Shinder V.,Wolf D.G.
Human cytomegalovirus UL97 kinase and nonkinase functions mediate viral cytoplasmic secondary envelopment.
J. Virol.
85
3375-3384
2011
1011940
Sharma M.,Bender B.J.,Kamil J.P.,Lye M.F.,Pesola J.M.,Reim N.I.,Hogle J.M.,Coen D.M.
Human cytomegalovirus UL97 phosphorylates the viral nuclear egress complex.
J. Virol.
89
523-534
2015
1011941
Businger R.,Deutschmann J.,Gruska I.,Milbradt J.,Wiebusch L.,Gramberg T.,Schindler M.
Human cytomegalovirus overcomes SAMHD1 restriction in macrophages via pUL97.
Nat. Microbiol.
4
2260-2272
2019
1011942
Zhang K.,Lv D.W.,Li R.
Conserved Herpesvirus Protein Kinases Target SAMHD1 to Facilitate Virus Replication.
Cell Rep.
28
449-459
2019
