Sequence of POLG_POL1S
EC Number:3.4.22.28
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
Selective cleavage of Gln-/-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly
Other sequences found for EC No. 3.4.22.28
General information:
Sequence
0 MGAQVSSQKV GAHENSNRAY GGSTINYTTI NYYRDSASNA ASKQDFSQDP SKFTEPIKDV
60 LIKTSPMLNS PNIEACGYSD RVLQLTLGNS TITTQEAANS VVAYGRWPEY LRDSEANPVD
120 QPTEPDVAAC RFYTLDTVSW TKESRGWWWK LPDALRDMGL FGQNMYYHYL GRSGYTVHVQ
180 CNASKFHQGA LGVFAVPEMC LAGDSNTTTM HTSYQNANPG EKGGTFTGTF TPDDNQTSPA
240 RRFCPVDYLF GNGTLLGNAF VFPHQIINLR TNNCATLVLP YVNSLSIDSM VKHNNWGIAI
300 LPLAPLNFAS ESSPEIPITL TIAPMCCEFN GLRNITLPRL QGLPVMNTPG SNQYLTADNF
360 QSPCALPEFD VTPPIDIPGE VKNMMELAEI DTMIPFDLSA KKKNTMEMYR VRLSDKPHTD
420 DPILCLSLSP ASDPRLSHTM LGEILNYYTH WAGSLKFTFL FCGSMMATGK LLVSYAPPGA
480 DPPKKRKEAM LGTHVIWDIG LQSSCTMVVP WISNTTYRQT IDDSFTEGGY ISVFYQTRIV
540 VPLSTPREMD ILGFVSACND FSVRLMRDTT HIEQKALAQG LGQMLESMID NTVRETVGAA
600 TSRDALPNTE ASGPAHSKEI PALTAVETGA TNPLVPSDTV QTRHVVQHRS RSESSIESFF
660 ARGACVAIIT VDNSASTKNK DKLFTVWKIT YKDTVQLRRK LEFFTYSRFD MEFTFVVTAN
720 FTETNNGHAL NQVYQIMYVP PGAPVPEKWD DYTWQTSSNP SIFYTYGTAP ARISVPYVGI
780 SNAYSHFYDG FSKVPLKDQS AALGDSLYGA ASLNDFGILA VRVVNDHNPT KVTSKIRVYL
840 KPKHIRVWCP RPPRAVAYYG PGVDYKDGTL TPLSTKDLTT YGFGHQNKAV YTAGYKICNY
900 HLATQEDLQN AVNVMWNRDL LVTESRAQGT DSIARCNCNA GVYYCESRRK YYPVSFVGPT
960 FQYMEANNYY PARYQSHMLI GHGFASPGDC GGILRCHHGV IGIITAGGEG LVAFTDIRDL
1020 YAYEEEAMEQ GITNYIESLG AAFGSGFTQQ IGDKITELTN MVTSTITEKL LKNLIKIISS
1080 LVIITRNYED TTTVLATLAL LGCDASPWQW LRKKACDVLE IPYVTKQGDS WLKKFTEACN
1140 AAKGLEWVSN KISKFIDWLK EKIIPQARDK LEFVTKLRQL EMLENQISTI HQSCPSQEHQ
1200 EILFNNVRWL SIQSKRFAPL YAVEAKRIQK LEHTINNYIQ FKSKHRIEPV CLLVHGSPGT
1260 GKSVATNLIA RAIAERENTS TYSLPPDPSH FDGYKQQGVV IMDDLNQNPD GADMKLFCQM
1320 VSTVEFIPPM ASLEEKGILF TSNYVLASTN SSRISPPTVA HSDALARRFA FDMDIQVMNE
1380 YSRDGKLNMA MATEMCKNCH QPANFKRCCP LVCGKAIQLM DKSSRVRYSI DQITTMIINE
1440 RNRRSNIGNC MEALFQGPLQ YKDLKIDIKT SPPPECINDL LQAVDSQEVR DYCEKKGWIV
1500 NITSQVQTER NINRAMTILQ AVTTFAAVAG VVYVMYKLFA GHQGAYTGLP NKKPNVPTIR
1560 TAKVQGPGFD YAVAMAKRNI VTATTSKGEF TMLGVHDNVA ILPTHASPGE SIVIDGKEVE
1620 ILDAKALEDQ AGTNLEITII TLKRNEKFRD IRPHIPTQIT ETNDGVLIVN TSKYPNMYVP
1680 VGAVTEQGYL NLGGRQTART LMYNFPTRAG QCGGVITCTG KVIGMHVGGN GSHGFAAALK
1740 RSYFTQSQGE IQWMRPSKEV GYPIINAPSK TKLEPSAFHY VFEGVKEPAV LTKNDPRLKT
1800 NFEEAIFSKY VGNKITEVDE HMKEAVDHYA GQLMSLDINT EQMCLEDAMY GTDGLEALDL
1860 STSAGYPYVA MGKKKRDILN KQTRDTKEMQ KLLDTYGINL PLVTYVKDEL RSKTKVEQGK
1920 SRLIEASSLN DSVAMRMAFG NLYAAFHKNP GVITGSAVGC DPDLFWSKIP VLMEEKLFAF
1980 DYTGYDASLS PAWFEALEMV LEKIGFGDRV DYIDYLNHSH HLYKNKTYCV KGGMPSGCSG
2040 TSIFNSMINN LIIRTLLLKT YKGIDLDHLK MIAYGDDVIA SYPHEVDASL LAQSGKDYGL
2100 TMTPADKSAI FETVTWENVT FLKRFFRADE KYPFLIHPVM PMKEIHESIR WTKDPRNTQD
2160 HVRSLCLLAW HNGEEEYNKF LAKIRSVPIG RALLLPEYST LYRRWLDSF
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
973189
Nomoto A.,Omata T.,Toyoda H.,Kuge S.,Horie H.,Kataoka Y.,Genba Y.,Nakano Y.,Imura N.
Complete nucleotide sequence of the attenuated poliovirus Sabin 1 strain genome.
Proc. Natl. Acad. Sci. U.S.A.
79
5793-5797
1982
973190
Toyoda H.,Nicklin M.J.,Murray M.G.,Anderson C.W.,Dunn J.J.,Studier F.W.,Wimmer E.
A second virus-encoded proteinase involved in proteolytic processing of poliovirus polyprotein.
Cell
45
761-770
1986
973191
Haemmerle T.,Hellen C.U.T.,Wimmer E.
Site-directed mutagenesis of the putative catalytic triad of poliovirus 3C proteinase.
J. Biol. Chem.
266
5412-5416
1991
973192
Visser L.J.,Langereis M.A.,Rabouw H.H.,Wahedi M.,Muntjewerff E.M.,de Groot R.J.,van Kuppeveld F.J.M.
Essential Role of Enterovirus 2A Protease in Counteracting Stress Granule Formation and the Induction of Type I Interferon.
J. Virol.
93
0-0
2019
