Sequence of POLG_FMDVS
EC Number:3.4.22.46
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
L-peptidase
P03311
Foot-and-mouth disease virus (isolate -/Spain/S8c1SantaPau/1970 serotype C)
2327
258126
Reaction
autocatalytically cleaves itself from the polyprotein of the foot-and-mouth disease virus by hydrolysis of a Lys-/-Gly bond, but then cleaves host cell initiation factor eIF-4G at bonds -Gly-/-Arg- and -Lys-/-Arg-
Other sequences found for EC No. 3.4.22.46
General information:
Sequence
0 MNTTDCFIAV VNAIKEVRAL FLPRTAGKME FTLHDGEKKV FYSRPNNHDN CWLNTILQLF
60 RYVDEPFFDW VYNSPENLTL EAIKQLEELT GLELREGGPP ALVIWNIKHL LHTGIGTASR
120 PSEVCMVDGT DMCLADFHAG IFMKGREHAV FACVTSNGWY AIDDEDFYPW TPDPSDVLVF
180 VPYDQEPLNE GWKASVQRKL KGAGQSSPAT GSQNQSGNTG SIINNYYMQQ YQNSMDTQLG
240 DNAISGGSNE GSTDTTSTHT TNTQNNDWFS KLASSAFSGL FGALLADKKT EETTLLEDRI
300 LTTRNGHTTS TTQSSVGVTF GYATAEDSTS GPNTSGLETR VHQAERFFKM ALFDWVPSQN
360 FGHMHKVVLP HEPKGVYGGL VKSYAYMRNG WDVEVTAVGN QFNGGCLLVA LVPEMGDISD
420 REKYQLTLYP HQFINPRTNM TAHITVPYVG VNRYDQYKQH RPWTLVVMVV APLTTNTAGA
480 QQIKVYANIA PTNVHVAGEL PSKEGIFPVA CSDGYGNMVT TDPKTADPAY GKVYNPPRTA
540 LPGRFTNYLD VAEACPTFLM FENVPYVSTR TDGQRLLAKF DVSLAAKHMS NTYLAGLAQY
600 YTQYTGTINL HFMFTGPTDA KARYMVAYVP PGMDAPDNPE EAAHCIHAEW DTGLNSKFTF
660 SIPYISAADY AYTASHEAET TCVQGWVCVY QITHGKADAD ALVVSASAGK DFELRLPVDA
720 RQQTTTTGES ADPVTTTVEN YGGETQVQRR HHTDVAFVLD RFVKVTVSDN QHTLDVMQAH
780 KDNIVGALLR AATYYFSDLE IAVTHTGKLT WVPNGAPVSA LNNTTNPTAY HKGPVTRLAL
840 PYTAPHRVLA TAYTGTTTYT ASARGDLAHL TTTHARHLPT SFNFGAVKAE TITELLVRMK
900 RAELYCPRPI LPIQPTGDRH KQPLVAPAKQ LLNFDLLKLA GDVESNPGPF FFSDVRSNFS
960 KLVETINQMQ EDMSTKHGPD FNRLVSAFEE LASGVKAIRT GLDEAKPWYK LIKLLSRLSC
1020 MAAVAARSKD PVLVAIMLAD TGLEILDSTF VVKKISDSLS SLFHVPAPAF SFGAPILLAG
1080 LVKVASSFFR STPEDLERAE KQLKARDIND IFAILKNGEW LVKLILAIRD WIKAWIASEE
1140 KFVTMTDLVP GILEKQRDLN DPSKYKDAKE WLDNTRQVCL KSGNVHIANL CKVVAPAPSK
1200 SRPEPVVVCL RGKSGQGKSF LANVLAQAIS THLTGRTDSV WYCPPDPDHF DGYNQQTVVV
1260 MDDLGQNPDG KDFKYFAQMV STTGFIPPMA SLEDKGKPFS SKVIIATTNL YSGFTPKTMV
1320 CPDALNRRFH FDIDVSAKDG YKINNKLDII KALEDTHTNP VAMFQYDCAL LNGMAVEMKR
1380 LQQDMFKPQP PLQNVYQLVQ EVIERVELHE KVSSHPIFKQ ISIPSQKSVL YFLIEKGQHE
1440 AAIEFFEGMV HDSIKEELRP LIQQTSFVKR AFKRLKENFE IVALCLTLLA NIVIMIRETH
1500 KRQKMVDDAV NEYIEKANIT TDDQTLDEAE KNPLETSGAS TVGFRERTLP GQKARDDVNS
1560 EPAQPTEEQP QAEGPYAGPL ERQRPLKVRA KLPRQEGPYA GPMERQKPLK VKARAPVVKE
1620 GPYEGPVKKP VALKVKAKNL IVTESGAPPT DLQKMVMGNT KPVELILDGK TVAICCATGV
1680 FGTAYLVPRH LFAEKYDKIM LDGRALTDSD YRVFEFEIKV KGQDMLSDAA LMVLHRGNRV
1740 RDITKHFRDV ARMKKGTPVV GVINNADVGR LIFSGEALTY KDIVVCMDGD TMPGLFAYKA
1800 ATKAGYCGGA VLAKDGADTF IVGTHSAGGN GVGYCSCVSR SMLLKMKAHI DPEPHHEGLI
1860 VDTRDVEERV HVMRKTKLAP TVAHGVFNPE FGPAALSNKD PRLNEGVVLD EVIFSKHKGD
1920 TKMSAEDKAL FRRCAADYAS RLHSVLGTAN APLSIYEAIK GVDGLDAMEP DTAPGLPWAL
1980 QGKRRGALID FENGTVGPEV EAALKLMEKR EYKFACQTFL KDEIRPMEKV RAGKTRIVDV
2040 LPVEHILYTR MMIGRFCAQM HSNNGPQIGS AVGCNPDVDW QRFGTHFAQY RNVWDVDYSA
2100 FDANHCSDAM NIMFEEVFRT EFGFHPNAEW ILKTLVNTEH AYENKRITVE GGMPSGCSAT
2160 SIINTILNNI YVLYALRRHY EGVELDTYTM ISYGDDIVVA SDYDLDFEAL KPHFKSLGQT
2220 ITPADKSDKG FVLGHSITDV TFLKRHFHMD YGTGFYKPVM ASKTLEAILS FARRGTIQEK
2280 LISVAGLAVH SGPDEYRRLF EPFQGLFEIP SYRSLYLRWV NAVCGDA
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
973077
Toja M.,Escarmis C.,Domingo E.
Genomic nucleotide sequence of a foot-and-mouth disease virus clone and its persistent derivatives. Implications for the evolution of viral quasispecies during a persistent infection.
Virus Res.
64
161-171
1999
973078
Villanueva N.,Davila M.,Ortin J.,Domingo E.
Molecular cloning of cDNA from foot-and-mouth disease virus C1-Santa Pau (C-S8). Sequence of protein-VP1-coding segment.
Gene
23
185-194
1983
973079
Martinez-Salas E.,Ortin J.,Domingo E.
Sequence of the viral replicase gene from foot-and-mouth disease virus C1-Santa Pau (C-S8).
Gene
35
55-61
1985
973080
Moral-Lopez P.,Alvarez E.,Redondo N.,Skern T.,Carrasco L.
L protease from foot and mouth disease virus confers eIF2-independent translation for mRNAs bearing picornavirus IRES.
FEBS Lett.
588
4053-4059
2014
973081
Hewat E.A.,Verdaguer N.,Fita I.,Blakemore W.,Brookes S.,King A.,Newman J.,Domingo E.,Mateu M.G.,Stuart D.I.
Structure of the complex of an Fab fragment of a neutralizing antibody with foot-and-mouth disease virus: positioning of a highly mobile antigenic loop.
EMBO J.
16
1492-1500
1997
