Sequence of BGAT_HUMAN
EC Number:2.4.1.37
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
UDP-alpha-D-galactose + alpha-L-fucosyl-(1->2)-D-galactosyl-R = UDP + alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl(1->2)]-D-galactosyl-R
Other sequences found for EC No. 2.4.1.37
General information:
Sequence
0 MAEVLRTLAG KPKCHALRPM ILFLIMLVLV LFGYGVLSPR SLMPGSLERG FCMAVREPDH
60 LQRVSLPRMV YPQPKVLTPC RKDVLVVTPW LAPIVWEGTF NIDILNEQFR LQNTTIGLTV
120 FAIKKYVAFL KLFLETAEKH FMVGHRVHYY VFTDQPAAVP RVTLGTGRQL SVLEVRAYKR
180 WQDVSMRRME MISDFCERRF LSEVDYLVCV DVDMEFRDHV GVEILTPLFG TLHPGFYGSS
240 REAFTYERRP QSQAYIPKDE GDFYYLGGFF GGSVQEVQRL TRACHQAMMV DQANGIEAVW
300 HDESHLNKYL LRHKPTKVLS PEYLWDQQLL GWPAVLRKLR FTAVPKNHQA VRNP
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
903620
Yamamoto F.,Marken J.,Tsuji T.,White T.,Clausen H.,Hakomori S.
Cloning and characterization of DNA complementary to human UDP-GalNAc: Fuc alpha 1-->2Gal alpha 1-->3GalNAc transferase (histo-blood group A transferase) mRNA.
J. Biol. Chem.
265
1146-1151
1990
903621
Yamamoto F.,Clausen H.,White T.,Marken J.,Hakomori S.
Molecular genetic basis of the histo-blood group ABO system.
Nature
345
229-233
1990
903622
Bennett E.P.,Steffensen R.,Clausen H.,Weghuis D.O.,Geurts van Kessel A.
Genomic cloning of the human histo-blood group ABO locus.
Biochem. Biophys. Res. Commun.
206
318-325
1995
903623
Bennett E.P.,Steffensen R.,Clausen H.,Weghuis D.O.,Geurts van Kessel A.
Biochem. Biophys. Res. Commun.
211
347-347
1995
903625
Seltsam A.,Das Gupta C.,Bade-Doeding C.,Blasczyk R.
A weak blood group A phenotype caused by a translation-initiator mutation in the ABO gene.
Transfusion
46
434-440
2006
903626
Seltsam A.,Wagner F.F.,Gruger D.,Gupta C.D.,Bade-Doeding C.,Blasczyk R.
Weak blood group B phenotypes may be caused by variations in the CCAAT-binding factor/NF-Y enhancer region of the ABO gene.
Transfusion
47
2330-2335
2007
903627
Seltsam A.,Gruger D.,Just B.,Figueiredo C.,Gupta C.D.,Deluca D.S.,Blasczyk R.
Aberrant intracellular trafficking of a variant B glycosyltransferase.
Transfusion
48
1898-1905
2008
903629
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
903630
Seltsam A.,Hallensleben M.,Kollmann A.,Blasczyk R.
The nature of diversity and diversification at the ABO locus.
Blood
102
3035-3042
2003
903631
Ogasawara K.,Yabe R.,Uchikawa M.,Saitou N.,Bannai M.,Nakata K.,Takenaka M.,Fujisawa K.,Ishikawa Y.,Juji T.,Tokunaga K.
Molecular genetic analysis of variant phenotypes of the ABO blood group system.
Blood
88
2732-2737
1996
903632
Olsson M.L.,Chester M.A.
Heterogeneity of the blood group Ax allele: genetic recombination of common alleles can result in the Ax phenotype.
Transfus. Med.
8
231-238
1998
903633
Roubinet F.,Despiau S.,Calafell F.,Jin F.,Bertanpetit J.,Saitou N.,Blancher A.
Evolution of the O alleles of the human ABO blood group gene.
Transfusion
44
707-715
2004
903635
Kominato Y.,McNeill P.D.,Yamamoto M.,Russell M.,Hakomori S.,Yamamoto F.
Animal histo-blood group ABO genes.
Biochem. Biophys. Res. Commun.
189
154-164
1992
903636
Yamamoto F.,Hakomori S.
Sugar-nucleotide donor specificity of histo-blood group A and B transferases is based on amino acid substitutions.
J. Biol. Chem.
265
19257-19262
1990
903637
Yu L.C.,Lee H.L.,Chan Y.S.,Lin M.
The molecular basis for the B(A) allele: an amino acid alteration in the human histoblood group B alpha-(1,3)-galactosyltransferase increases its intrinsic alpha-(1,3)-N-acetylgalactosaminyltransferase activity.
Biochem. Biophys. Res. Commun.
262
487-493
1999
903638
Patenaude S.I.,Seto N.O.L.,Borisova S.N.,Szpacenko A.,Marcus S.L.,Palcic M.M.,Evans S.V.
The structural basis for specificity in human ABO(H) blood group biosynthesis.
Nat. Struct. Biol.
9
685-690
2002
903639
Marcus S.L.,Polakowski R.,Seto N.O.L.,Leinala E.,Borisova S.,Blancher A.,Roubinet F.,Evans S.V.,Palcic M.M.
A single point mutation reverses the donor specificity of human blood group B-synthesizing galactosyltransferase.
J. Biol. Chem.
278
12403-12405
2003
903640
Nguyen H.P.,Seto N.O.L.,Cai Y.,Leinala E.K.,Borisova S.N.,Palcic M.M.,Evans S.V.
The influence of an intramolecular hydrogen bond in differential recognition of inhibitory acceptor analogs by human ABO(H) blood group A and B glycosyltransferases.
J. Biol. Chem.
278
49191-49195
2003
903641
Lee H.J.,Barry C.H.,Borisova S.N.,Seto N.O.L.,Zheng R.B.,Blancher A.,Evans S.V.,Palcic M.M.
Structural basis for the inactivity of human blood group O2 glycosyltransferase.
J. Biol. Chem.
280
525-529
2005
903642
Letts J.A.,Rose N.L.,Fang Y.R.,Barry C.H.,Borisova S.N.,Seto N.O.L.,Palcic M.M.,Evans S.V.
Differential recognition of the type I and II H antigen acceptors by the human ABO(H) blood group A and B glycosyltransferases.
J. Biol. Chem.
281
3625-3632
2006
903643
Persson M.,Letts J.A.,Hosseini-Maaf B.,Borisova S.N.,Palcic M.M.,Evans S.V.,Olsson M.L.
Structural effects of naturally occurring human blood group B galactosyltransferase mutations adjacent to the DXD motif.
J. Biol. Chem.
282
9564-9570
2007
