Sequence of ALK_HUMAN
EC Number:2.7.10.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Other sequences found for EC No. 2.7.10.1
General information:
Sequence
0 MGAIGLLWLL PLLLSTAAVG SGMGTGQRAG SPAAGPPLQP REPLSYSRLQ RKSLAVDFVV
60 PSLFRVYARD LLLPPSSSEL KAGRPEARGS LALDCAPLLR LLGPAPGVSW TAGSPAPAEA
120 RTLSRVLKGG SVRKLRRAKQ LVLELGEEAI LEGCVGPPGE AAVGLLQFNL SELFSWWIRQ
180 GEGRLRIRLM PEKKASEVGR EGRLSAAIRA SQPRLLFQIF GTGHSSLESP TNMPSPSPDY
240 FTWNLTWIMK DSFPFLSHRS RYGLECSFDF PCELEYSPPL HDLRNQSWSW RRIPSEEASQ
300 MDLLDGPGAE RSKEMPRGSF LLLNTSADSK HTILSPWMRS SSEHCTLAVS VHRHLQPSGR
360 YIAQLLPHNE AAREILLMPT PGKHGWTVLQ GRIGRPDNPF RVALEYISSG NRSLSAVDFF
420 ALKNCSEGTS PGSKMALQSS FTCWNGTVLQ LGQACDFHQD CAQGEDESQM CRKLPVGFYC
480 NFEDGFCGWT QGTLSPHTPQ WQVRTLKDAR FQDHQDHALL LSTTDVPASE SATVTSATFP
540 APIKSSPCEL RMSWLIRGVL RGNVSLVLVE NKTGKEQGRM VWHVAAYEGL SLWQWMVLPL
600 LDVSDRFWLQ MVAWWGQGSR AIVAFDNISI SLDCYLTISG EDKILQNTAP KSRNLFERNP
660 NKELKPGENS PRQTPIFDPT VHWLFTTCGA SGPHGPTQAQ CNNAYQNSNL SVEVGSEGPL
720 KGIQIWKVPA TDTYSISGYG AAGGKGGKNT MMRSHGVSVL GIFNLEKDDM LYILVGQQGE
780 DACPSTNQLI QKVCIGENNV IEEEIRVNRS VHEWAGGGGG GGGATYVFKM KDGVPVPLII
840 AAGGGGRAYG AKTDTFHPER LENNSSVLGL NGNSGAAGGG GGWNDNTSLL WAGKSLQEGA
900 TGGHSCPQAM KKWGWETRGG FGGGGGGCSS GGGGGGYIGG NAASNNDPEM DGEDGVSFIS
960 PLGILYTPAL KVMEGHGEVN IKHYLNCSHC EVDECHMDPE SHKVICFCDH GTVLAEDGVS
1020 CIVSPTPEPH LPLSLILSVV TSALVAALVL AFSGIMIVYR RKHQELQAMQ MELQSPEYKL
1080 SKLRTSTIMT DYNPNYCFAG KTSSISDLKE VPRKNITLIR GLGHGAFGEV YEGQVSGMPN
1140 DPSPLQVAVK TLPEVCSEQD ELDFLMEALI ISKFNHQNIV RCIGVSLQSL PRFILLELMA
1200 GGDLKSFLRE TRPRPSQPSS LAMLDLLHVA RDIACGCQYL EENHFIHRDI AARNCLLTCP
1260 GPGRVAKIGD FGMARDIYRA SYYRKGGCAM LPVKWMPPEA FMEGIFTSKT DTWSFGVLLW
1320 EIFSLGYMPY PSKSNQEVLE FVTSGGRMDP PKNCPGPVYR IMTQCWQHQP EDRPNFAIIL
1380 ERIEYCTQDP DVINTALPIE YGPLVEEEEK VPVRPKDPEG VPPLLVSQQA KREEERSPAA
1440 PPPLPTTSSG KAAKKPTAAE ISVRVPRGPA VEGGHVNMAF SQSNPPSELH KVHGSRNKPT
1500 SLWNPTYGSW FTEKPTKKNN PIAKKEPHDR GNLGLEGSCT VPPNVATGRL PGASLLLEPS
1560 SLTANMKEVP LFRLRHFPCG NVNYGYQQQG LPLEAATAPG AGHYEDTILK SKNSMNQPGP
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
896963
Morris S.W.,Naeve C.W.,Mathew P.,James P.L.,Kirstein M.N.,Cui X.,Witte D.P.
ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK).
Oncogene
14
2175-2188
1997
896965
Iwahara T.,Fujimoto J.,Wen D.,Cupples R.,Bucay N.,Arakawa T.,Mori S.,Ratzkin B.,Yamamoto T.
Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system.
Oncogene
14
439-449
1997
896967
Hillier L.W.,Graves T.A.,Fulton R.S.,Fulton L.A.,Pepin K.H.,Minx P.,Wagner-McPherson C.,Layman D.,Wylie K.,Sekhon M.,Becker M.C.,Fewell G.A.,Delehaunty K.D.,Miner T.L.,Nash W.E.,Kremitzki C.,Oddy L.,Du H.,Sun H.,Bradshaw-Cordum H.,Ali J.,Carter J.,Cordes M.,Harris A.,Isak A.,van Brunt A.,Nguyen C.,Du F.,Courtney L.,Kalicki J.,Ozersky P.,Abbott S.,Armstrong J.,Belter E.A.,Caruso L.,Cedroni M.,Cotton M.,Davidson T.,Desai A.,Elliott G.,Erb T.,Fronick C.,Gaige T.,Haakenson W.,Haglund K.,Holmes A.,Harkins R.,Kim K.,Kruchowski S.S.,Strong C.M.,Grewal N.,Goyea E.,Hou S.,Levy A.,Martinka S.,Mead K.,McLellan M.D.,Meyer R.,Randall-Maher J.,Tomlinson C.,Dauphin-Kohlberg S.,Kozlowicz-Reilly A.,Shah N.,Swearengen-Shahid S.,Snider J.,Strong J.T.,Thompson J.,Yoakum M.,Leonard S.,Pearman C.,Trani L.,Radionenko M.,Waligorski J.E.,Wang C.,Rock S.M.,Tin-Wollam A.-M.,Maupin R.,Latreille P.,Wendl M.C.,Yang S.-P.,Pohl C.,Wallis J.W.,Spieth J.,Bieri T.A.,Berkowicz N.,Nelson J.O.,Osborne J.,Ding L.,Meyer R.,Sabo A.,Shotland Y.,Sinha P.,Wohldmann P.E.,Cook L.L.,Hickenbotham M.T.,Eldred J.,Williams D.,Jones T.A.,She X.,Ciccarelli F.D.,Izaurralde E.,Taylor J.,Schmutz J.,Myers R.M.,Cox D.R.,Huang X.,McPherson J.D.,Mardis E.R.,Clifton S.W.,Warren W.C.,Chinwalla A.T.,Eddy S.R.,Marra M.A.,Ovcharenko I.,Furey T.S.,Miller W.,Eichler E.E.,Bork P.,Suyama M.,Torrents D.,Waterston R.H.,Wilson R.K.
Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
Nature
434
724-731
2005
896968
Morris S.W.,Kirstein M.N.,Valentine M.B.,Dittmer K.G.,Shapiro D.N.,Saltman D.L.,Look A.T.
Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma.
Science
263
1281-1284
1994
896969
Soda M.,Choi Y.L.,Enomoto M.,Takada S.,Yamashita Y.,Ishikawa S.,Fujiwara S.,Watanabe H.,Kurashina K.,Hatanaka H.,Bando M.,Ohno S.,Ishikawa Y.,Aburatani H.,Niki T.,Sohara Y.,Sugiyama Y.,Mano H.
Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer.
Nature
448
561-566
2007
896970
Simonitsch I.,Polgar D.,Hajek M.,Duchek P.,Skrzypek B.,Fassl S.,Lamprecht A.,Schmidt G.,Krupitza G.,Cerni C.
The cytoplasmic truncated receptor tyrosine kinase ALK homodimer immortalizes and cooperates with ras in cellular transformation.
FASEB J.
15
1416-1418
2001
896971
Souttou B.,Carvalho N.B.,Raulais D.,Vigny M.
Activation of anaplastic lymphoma kinase receptor tyrosine kinase induces neuronal differentiation through the mitogen-activated protein kinase pathway.
J. Biol. Chem.
276
9526-9531
2001
896972
Stoica G.E.,Kuo A.,Aigner A.,Sunitha I.,Souttou B.,Malerczyk C.,Caughey D.J.,Wen D.,Karavanov A.,Riegel A.T.,Wellstein A.
Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin.
J. Biol. Chem.
276
16772-16779
2001
896973
Cools J.,Wlodarska I.,Somers R.,Mentens N.,Pedeutour F.,Maes B.,De Wolf-Peeters C.,Pauwels P.,Hagemeijer A.,Marynen P.
Identification of novel fusion partners of ALK, the anaplastic lymphoma kinase, in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor.
Genes Chromosomes Cancer
34
354-362
2002
896974
Powers C.,Aigner A.,Stoica G.E.,McDonnell K.,Wellstein A.
Pleiotrophin signaling through anaplastic lymphoma kinase is rate-limiting for glioblastoma growth.
J. Biol. Chem.
277
14153-14158
2002
896975
Bowden E.T.,Stoica G.E.,Wellstein A.
Anti-apoptotic signaling of pleiotrophin through its receptor, anaplastic lymphoma kinase.
J. Biol. Chem.
277
35862-35868
2002
896976
Stoica G.E.,Kuo A.,Powers C.,Bowden E.T.,Sale E.B.,Riegel A.T.,Wellstein A.
Midkine binds to anaplastic lymphoma kinase (ALK) and acts as a growth factor for different cell types.
J. Biol. Chem.
277
35990-35998
2002
896977
Motegi A.,Fujimoto J.,Kotani M.,Sakuraba H.,Yamamoto T.
ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth.
J. Cell Sci.
117
3319-3329
2004
896978
Donella-Deana A.,Marin O.,Cesaro L.,Gunby R.H.,Ferrarese A.,Coluccia A.M.,Tartari C.J.,Mologni L.,Scapozza L.,Gambacorti-Passerini C.,Pinna L.A.
Unique substrate specificity of anaplastic lymphoma kinase (ALK): development of phosphoacceptor peptides for the assay of ALK activity.
Biochemistry
44
8533-8542
2005
896979
Lu K.V.,Jong K.A.,Kim G.Y.,Singh J.,Dia E.Q.,Yoshimoto K.,Wang M.Y.,Cloughesy T.F.,Nelson S.F.,Mischel P.S.
Differential induction of glioblastoma migration and growth by two forms of pleiotrophin.
J. Biol. Chem.
280
26953-26964
2005
896980
Gouzi J.Y.,Moog-Lutz C.,Vigny M.,Brunet-de Carvalho N.
Role of the subcellular localization of ALK tyrosine kinase domain in neuronal differentiation of PC12 cells.
J. Cell Sci.
118
5811-5823
2005
896981
Rush J.,Moritz A.,Lee K.A.,Guo A.,Goss V.L.,Spek E.J.,Zhang H.,Zha X.-M.,Polakiewicz R.D.,Comb M.J.
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
Nat. Biotechnol.
23
94-101
2005
896982
Panagopoulos I.,Nilsson T.,Domanski H.A.,Isaksson M.,Lindblom P.,Mertens F.,Mandahl N.
Fusion of the SEC31L1 and ALK genes in an inflammatory myofibroblastic tumor.
Int. J. Cancer
118
1181-1186
2006
896983
Degoutin J.,Vigny M.,Gouzi J.Y.
ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation.
FEBS Lett.
581
727-734
2007
896984
Perez-Pinera P.,Zhang W.,Chang Y.,Vega J.A.,Deuel T.F.
Anaplastic lymphoma kinase is activated through the pleiotrophin/receptor protein-tyrosine phosphatase beta/zeta signaling pathway: an alternative mechanism of receptor tyrosine kinase activation.
J. Biol. Chem.
282
28683-28690
2007
896985
Kuo A.H.,Stoica G.E.,Riegel A.T.,Wellstein A.
Recruitment of insulin receptor substrate-1 and activation of NF-kappaB essential for midkine growth signaling through anaplastic lymphoma kinase.
Oncogene
26
859-869
2007
896986
Palmer R.H.,Vernersson E.,Grabbe C.,Hallberg B.
Anaplastic lymphoma kinase: signalling in development and disease.
Biochem. J.
420
345-361
2009
896987
Lipson D.,Capelletti M.,Yelensky R.,Otto G.,Parker A.,Jarosz M.,Curran J.A.,Balasubramanian S.,Bloom T.,Brennan K.W.,Donahue A.,Downing S.R.,Frampton G.M.,Garcia L.,Juhn F.,Mitchell K.C.,White E.,White J.,Zwirko Z.,Peretz T.,Nechushtan H.,Soussan-Gutman L.,Kim J.,Sasaki H.,Kim H.R.,Park S.I.,Ercan D.,Sheehan C.E.,Ross J.S.,Cronin M.T.,Jaenne P.A.,Stephens P.J.
Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies.
Nat. Med.
18
382-384
2012
896988
Murray P.B.,Lax I.,Reshetnyak A.,Ligon G.F.,Lillquist J.S.,Natoli E.J. Jr.,Shi X.,Folta-Stogniew E.,Gunel M.,Alvarado D.,Schlessinger J.
Heparin is an activating ligand of the orphan receptor tyrosine kinase ALK.
Sci. Signal.
8
0-0
2015
896989
Reshetnyak A.V.,Mohanty J.,Tome F.,Puleo D.E.,Plotnikov A.N.,Ahmed M.,Kaur N.,Poliakov A.,Cinnaiyan A.M.,Lax I.,Schlessinger J.
Identification of a biologically active fragment of ALK and LTK-Ligand 2 (augmentor-alpha).
Proc. Natl. Acad. Sci. U.S.A.
115
8340-8345
2018
896990
Borenaes M.,Umapathy G.,Lai W.Y.,Lind D.E.,Witek B.,Guan J.,Mendoza-Garcia P.,Masudi T.,Claeys A.,Chuang T.P.,El Wakil A.,Arefin B.,Fransson S.,Koster J.,Johansson M.,Gaarder J.,Van den Eynden J.,Hallberg B.,Palmer R.H.
ALK ligand ALKAL2 potentiates MYCN-driven neuroblastoma in the absence of ALK mutation.
EMBO J.
40
0-0
2021
896992
Lee C.C.,Jia Y.,Li N.,Sun X.,Ng K.,Ambing E.,Gao M.Y.,Hua S.,Chen C.,Kim S.,Michellys P.Y.,Lesley S.A.,Harris J.L.,Spraggon G.
Crystal structure of the ALK (anaplastic lymphoma kinase) catalytic domain.
Biochem. J.
430
425-437
2010
896993
Bossi R.T.,Saccardo M.B.,Ardini E.,Menichincheri M.,Rusconi L.,Magnaghi P.,Orsini P.,Avanzi N.,Borgia A.L.,Nesi M.,Bandiera T.,Fogliatto G.,Bertrand J.A.
Crystal structures of anaplastic lymphoma kinase in complex with ATP competitive inhibitors.
Biochemistry
49
6813-6825
2010
896994
Koshiba S.,Li H.,Motoda Y.,Tomizawa T.,Kasai T.,Tochio N.,Yabuki T.,Harada T.,Watanabe S.,Tanaka A.,Shirouzu M.,Kigawa T.,Yamamoto T.,Yokoyama S.
Structural basis for the recognition of nucleophosmin-anaplastic lymphoma kinase oncoprotein by the phosphotyrosine binding domain of Suc1-associated neurotrophic factor-induced tyrosine-phosphorylated target-2.
J. Struct. Funct. Genomics
11
125-141
2010
896996
Sakamoto H.,Tsukaguchi T.,Hiroshima S.,Kodama T.,Kobayashi T.,Fukami T.A.,Oikawa N.,Tsukuda T.,Ishii N.,Aoki Y.
CH5424802, a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant.
Cancer Cell
19
679-690
2011
896997
Epstein L.F.,Chen H.,Emkey R.,Whittington D.A.
The R1275Q neuroblastoma mutant and certain ATP-competitive inhibitors stabilize alternative activation loop conformations of anaplastic lymphoma kinase.
J. Biol. Chem.
287
37447-37457
2012
896998
De Munck S.,Provost M.,Kurikawa M.,Omori I.,Mukohyama J.,Felix J.,Bloch Y.,Abdel-Wahab O.,Bazan J.F.,Yoshimi A.,Savvides S.N.
Structural basis of cytokine-mediated activation of ALK family receptors.
Nature
600
143-147
2021
896999
Reshetnyak A.V.,Rossi P.,Myasnikov A.G.,Sowaileh M.,Mohanty J.,Nourse A.,Miller D.J.,Lax I.,Schlessinger J.,Kalodimos C.G.
Mechanism for the activation of the anaplastic lymphoma kinase receptor.
Nature
600
153-157
2021
897000
Greenman C.,Stephens P.,Smith R.,Dalgliesh G.L.,Hunter C.,Bignell G.,Davies H.,Teague J.,Butler A.,Stevens C.,Edkins S.,O'Meara S.,Vastrik I.,Schmidt E.E.,Avis T.,Barthorpe S.,Bhamra G.,Buck G.,Choudhury B.,Clements J.,Cole J.,Dicks E.,Forbes S.,Gray K.,Halliday K.,Harrison R.,Hills K.,Hinton J.,Jenkinson A.,Jones D.,Menzies A.,Mironenko T.,Perry J.,Raine K.,Richardson D.,Shepherd R.,Small A.,Tofts C.,Varian J.,Webb T.,West S.,Widaa S.,Yates A.,Cahill D.P.,Louis D.N.,Goldstraw P.,Nicholson A.G.,Brasseur F.,Looijenga L.,Weber B.L.,Chiew Y.-E.,DeFazio A.,Greaves M.F.,Green A.R.,Campbell P.,Birney E.,Easton D.F.,Chenevix-Trench G.,Tan M.-H.,Khoo S.K.,Teh B.T.,Yuen S.T.,Leung S.Y.,Wooster R.,Futreal P.A.,Stratton M.R.
Patterns of somatic mutation in human cancer genomes.
Nature
446
153-158
2007
897001
Mosse Y.P.,Laudenslager M.,Longo L.,Cole K.A.,Wood A.,Attiyeh E.F.,Laquaglia M.J.,Sennett R.,Lynch J.E.,Perri P.,Laureys G.,Speleman F.,Kim C.,Hou C.,Hakonarson H.,Torkamani A.,Schork N.J.,Brodeur G.M.,Tonini G.P.,Rappaport E.,Devoto M.,Maris J.M.
Identification of ALK as a major familial neuroblastoma predisposition gene.
Nature
455
930-935
2008
897002
Janoueix-Lerosey I.,Lequin D.,Brugieres L.,Ribeiro A.,de Pontual L.,Combaret V.,Raynal V.,Puisieux A.,Schleiermacher G.,Pierron G.,Valteau-Couanet D.,Frebourg T.,Michon J.,Lyonnet S.,Amiel J.,Delattre O.
Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma.
Nature
455
967-970
2008
897003
George R.E.,Sanda T.,Hanna M.,Froehling S.,Luther W. II,Zhang J.,Ahn Y.,Zhou W.,London W.B.,McGrady P.,Xue L.,Zozulya S.,Gregor V.E.,Webb T.R.,Gray N.S.,Gilliland D.G.,Diller L.,Greulich H.,Morris S.W.,Meyerson M.,Look A.T.
Activating mutations in ALK provide a therapeutic target in neuroblastoma.
Nature
455
975-978
2008
897004
Mazot P.,Cazes A.,Boutterin M.C.,Figueiredo A.,Raynal V.,Combaret V.,Hallberg B.,Palmer R.H.,Delattre O.,Janoueix-Lerosey I.,Vigny M.
The constitutive activity of the ALK mutated at positions F1174 or R1275 impairs receptor trafficking.
Oncogene
30
2017-2025
2011
