Sequence of ADH_DROME
EC Number:1.1.1.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
a primary alcohol + NAD+ = an aldehyde + NADH + H+
Other sequences found for EC No. 1.1.1.1
General information:
Sequence
0 MSFTLTNKNV IFVAGLGGIG LDTSKELLKR DLKNLVILDR IENPAAIAEL KAINPKVTVT
60 FYPYDVTVPI AETTKLLKTI FAQLKTVDVL INGAGILDDH QIERTIAVNY TGLVNTTTAI
120 LDFWDKRKGG PGGIICNIGS VTGFNAIYQV PVYSGTKAAV VNFTSSLAKL APITGVTAYT
180 VNPGITRTTL VHKFNSWLDV EPQVAEKLLA HPTQPSLACA ENFVKAIELN QNGAIWKLDL
240 GTLEAIQWTK HWDSGI
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
895545
Benyajati C.,Place A.R.,Powers D.A.,Sofer W.
Alcohol dehydrogenase gene of Drosophila melanogaster: relationship of intervening sequences to functional domains in the protein.
Proc. Natl. Acad. Sci. U.S.A.
78
2717-2721
1981
895546
Kubli E.,Schmidt T.,Martin P.F.,Sofer W.
In vitro suppression of a nonsense mutant of Drosophila melanogaster.
Nucleic Acids Res.
10
7145-7152
1982
895547
Kreitman M.
Nucleotide polymorphism at the alcohol dehydrogenase locus of Drosophila melanogaster.
Nature
304
412-417
1983
895548
Martin P.F.,Place A.R.,Pentz E.,Sofer W.
UGA nonsense mutation in the alcohol dehydrogenase gene of Drosophila melanogaster.
J. Mol. Biol.
184
221-229
1985
895549
Kreitman M.E.,Aguade M.
Excess polymorphism at the Adh locus in Drosophila melanogaster.
Genetics
114
93-110
1986
895550
Chia W.,Savakis C.,Karp R.,Ashburner M.
Adhn4 of Drosophila melanogaster is a nonsense mutation.
Nucleic Acids Res.
15
3931-3931
1987
895551
Collet C.
Recent origin for a thermostable alcohol dehydrogenase allele of Drosophila melanogaster.
J. Mol. Evol.
27
142-146
1988
895552
Eisses K.T.,Andriesse A.J.,de Boer A.D.,Thorig G.E.W.,Weisbeek P.J.
Analysis of the gene encoding the multifunctional alcohol dehydrogenase allozyme ADH-71k of Drosophila melanogaster.
Mol. Biol. Evol.
7
459-469
1990
895553
Kreitman M.,Hudson R.R.
Inferring the evolutionary histories of the Adh and Adh-dup loci in Drosophila melanogaster from patterns of polymorphism and divergence.
Genetics
127
565-582
1991
895554
Laurie C.C.,Bridgham J.T.,Choudhary M.
Associations between DNA sequence variation and variation in expression of the Adh gene in natural populations of Drosophila melanogaster.
Genetics
129
489-499
1991
895555
Dunn R.C.,Laurie C.C.
Effects of a transposable element insertion on alcohol dehydrogenase expression in Drosophila melanogaster.
Genetics
140
667-677
1995
895557
Begun D.,Betancourt A.,Langley C.,Stephan W.
Is the fast/slow allozyme variation at the Adh locus of Drosophila melanogaster an ancient balanced polymorphism?
Mol. Biol. Evol.
16
1816-1819
1999
895558
Ashburner M.,Misra S.,Roote J.,Lewis S.E.,Blazej R.G.,Davis T.,Doyle C.,Galle R.F.,George R.A.,Harris N.L.,Hartzell G.,Harvey D.A.,Hong L.,Houston K.A.,Hoskins R.A.,Johnson G.,Martin C.,Moshrefi A.R.,Palazzolo M.,Reese M.G.,Spradling A.C.,Tsang G.,Wan K.H.,Whitelaw K.,Celniker S.E.,Rubin G.M.
An exploration of the sequence of a 2.9-Mb region of the genome of Drosophila melanogaster: the Adh region.
Genetics
153
179-219
1999
895559
Adams M.D.,Celniker S.E.,Holt R.A.,Evans C.A.,Gocayne J.D.,Amanatides P.G.,Scherer S.E.,Li P.W.,Hoskins R.A.,Galle R.F.,George R.A.,Lewis S.E.,Richards S.,Ashburner M.,Henderson S.N.,Sutton G.G.,Wortman J.R.,Yandell M.D.,Zhang Q.,Chen L.X.,Brandon R.C.,Rogers Y.-H.C.,Blazej R.G.,Champe M.,Pfeiffer B.D.,Wan K.H.,Doyle C.,Baxter E.G.,Helt G.,Nelson C.R.,Miklos G.L.G.,Abril J.F.,Agbayani A.,An H.-J.,Andrews-Pfannkoch C.,Baldwin D.,Ballew R.M.,Basu A.,Baxendale J.,Bayraktaroglu L.,Beasley E.M.,Beeson K.Y.,Benos P.V.,Berman B.P.,Bhandari D.,Bolshakov S.,Borkova D.,Botchan M.R.,Bouck J.,Brokstein P.,Brottier P.,Burtis K.C.,Busam D.A.,Butler H.,Cadieu E.,Center A.,Chandra I.,Cherry J.M.,Cawley S.,Dahlke C.,Davenport L.B.,Davies P.,de Pablos B.,Delcher A.,Deng Z.,Mays A.D.,Dew I.,Dietz S.M.,Dodson K.,Doup L.E.,Downes M.,Dugan-Rocha S.,Dunkov B.C.,Dunn P.,Durbin K.J.,Evangelista C.C.,Ferraz C.,Ferriera S.,Fleischmann W.,Fosler C.,Gabrielian A.E.,Garg N.S.,Gelbart W.M.,Glasser K.,Glodek A.,Gong F.,Gorrell J.H.,Gu Z.,Guan P.,Harris M.,Harris N.L.,Harvey D.A.,Heiman T.J.,Hernandez J.R.,Houck J.,Hostin D.,Houston K.A.,Howland T.J.,Wei M.-H.,Ibegwam C.,Jalali M.,Kalush F.,Karpen G.H.,Ke Z.,Kennison J.A.,Ketchum K.A.,Kimmel B.E.,Kodira C.D.,Kraft C.L.,Kravitz S.,Kulp D.,Lai Z.,Lasko P.,Lei Y.,Levitsky A.A.,Li J.H.,Li Z.,Liang Y.,Lin X.,Liu X.,Mattei B.,McIntosh T.C.,McLeod M.P.,McPherson D.,Merkulov G.,Milshina N.V.,Mobarry C.,Morris J.,Moshrefi A.,Mount S.M.,Moy M.,Murphy B.,Murphy L.,Muzny D.M.,Nelson D.L.,Nelson D.R.,Nelson K.A.,Nixon K.,Nusskern D.R.,Pacleb J.M.,Palazzolo M.,Pittman G.S.,Pan S.,Pollard J.,Puri V.,Reese M.G.,Reinert K.,Remington K.,Saunders R.D.C.,Scheeler F.,Shen H.,Shue B.C.,Siden-Kiamos I.,Simpson M.,Skupski M.P.,Smith T.J.,Spier E.,Spradling A.C.,Stapleton M.,Strong R.,Sun E.,Svirskas R.,Tector C.,Turner R.,Venter E.,Wang A.H.,Wang X.,Wang Z.-Y.,Wassarman D.A.,Weinstock G.M.,Weissenbach J.,Williams S.M.,Woodage T.,Worley K.C.,Wu D.,Yang S.,Yao Q.A.,Ye J.,Yeh R.-F.,Zaveri J.S.,Zhan M.,Zhang G.,Zhao Q.,Zheng L.,Zheng X.H.,Zhong F.N.,Zhong W.,Zhou X.,Zhu S.C.,Zhu X.,Smith H.O.,Gibbs R.A.,Myers E.W.,Rubin G.M.,Venter J.C.
The genome sequence of Drosophila melanogaster.
Science
287
2185-2195
2000
895560
Misra S.,Crosby M.A.,Mungall C.J.,Matthews B.B.,Campbell K.S.,Hradecky P.,Huang Y.,Kaminker J.S.,Millburn G.H.,Prochnik S.E.,Smith C.D.,Tupy J.L.,Whitfield E.J.,Bayraktaroglu L.,Berman B.P.,Bettencourt B.R.,Celniker S.E.,de Grey A.D.N.J.,Drysdale R.A.,Harris N.L.,Richter J.,Russo S.,Schroeder A.J.,Shu S.Q.,Stapleton M.,Yamada C.,Ashburner M.,Gelbart W.M.,Rubin G.M.,Lewis S.E.
Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.
Genome Biol.
3
0-0
2002
895561
Stapleton M.,Carlson J.W.,Brokstein P.,Yu C.,Champe M.,George R.A.,Guarin H.,Kronmiller B.,Pacleb J.M.,Park S.,Wan K.H.,Rubin G.M.,Celniker S.E.
A Drosophila full-length cDNA resource.
Genome Biol.
3
0-0
2002
895563
Retzios A.D.,Thatcher D.R.
Chemical basis of the electrophoretic variation observed at the alcohol dehydrogenase locus of Drosophila melanogaster.
Biochimie
61
701-704
1979
895564
Thatcher D.R.
The complete amino acid sequence of three alcohol dehydrogenase alleloenzymes (AdhN-11, AdhS and AdhUF) from the fruitfly Drosophila melanogaster.
Biochem. J.
187
875-883
1980
895566
Chia W.,Savakis C.,Karp R.,Pelham H.,Ashburner M.
Mutation of the Adh gene of Drosophila melanogaster containing an internal tandem duplication.
J. Mol. Biol.
186
679-688
1985
895567
Benyajati C.,Wang N.,Reddy A.,Weinberg E.,Sofer W.
Alcohol dehydrogenase in Drosophila: isolation and characterization of messenger RNA and cDNA clone.
Nucleic Acids Res.
8
5649-5667
1980
895568
Chambers G.K.,Laver W.G.,Campbell S.,Gibson J.B.
Structural analysis of an electrophoretically cryptic alcohol dehydrogenase variant from an Australian population of Drosophila melanogaster.
Proc. Natl. Acad. Sci. U.S.A.
78
3103-3107
1981
895569
Chen Z.,Lu L.,Shirley M.,Lee W.R.,Chang S.H.
Site-directed mutagenesis of glycine-14 and two 'critical' cysteinyl residues in Drosophila alcohol dehydrogenase.
Biochemistry
29
1112-1118
1990
895570
Albalat R.,Gonzalez-Duarte R.,Atrian S.
Protein engineering of Drosophila alcohol dehydrogenase. The hydroxyl group of Tyr152 is involved in the active site of the enzyme.
FEBS Lett.
308
235-239
1992
895571
Chen Z.,Jiang J.C.,Lin Z.-G.,Lee W.R.,Baker M.E.,Chang S.H.
Site-specific mutagenesis of Drosophila alcohol dehydrogenase: evidence for involvement of tyrosine-152 and lysine-156 in catalysis.
Biochemistry
32
3342-3346
1993
895572
Cols N.,Marfany G.,Atrian S.,Gonzalez-Duarte R.
Effect of site-directed mutagenesis on conserved positions of Drosophila alcohol dehydrogenase.
FEBS Lett.
319
90-94
1993
895573
Benach J.,Winberg J.-O.,Svendsen J.-S.,Atrian S.,Gonzalez-Duarte R.,Ladenstein R.
Drosophila alcohol dehydrogenase: acetate-enzyme interactions and novel insights into the effects of electrostatics on catalysis.
J. Mol. Biol.
345
579-598
2005
