Sequence of TPIS_HUMAN
EC Number:4.2.3.3
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
glycerone phosphate = 2-oxopropanal + phosphate
Other sequences found for EC No. 4.2.3.3
General information:
Sequence
0 MAPSRKFFVG GNWKMNGRKQ SLGELIGTLN AAKVPADTEV VCAPPTAYID FARQKLDPKI
60 AVAAQNCYKV TNGAFTGEIS PGMIKDCGAT WVVLGHSERR HVFGESDELI GQKVAHALAE
120 GLGVIACIGE KLDEREAGIT EKVVFEQTKV IADNVKDWSK VVLAYEPVWA IGTGKTATPQ
180 QAQEVHEKLR GWLKSNVSDA VAQSTRIIYG GSVTGATCKE LASQPDVDGF LVGGASLKPE
240 FVDIINAKQ
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
876495
Maquat L.E.,Chilcote R.,Ryan P.M.
Human triosephosphate isomerase cDNA and protein structure. Studies of triosephosphate isomerase deficiency in man.
J. Biol. Chem.
260
3748-3753
1985
876496
Brown J.R.,Daar I.O.,Krug J.R.,Maquat L.E.
Characterization of the functional gene and several processed pseudogenes in the human triosephosphate isomerase gene family.
Mol. Cell. Biol.
5
1694-1706
1985
876497
Ansari-Lari M.A.,Muzny D.M.,Lu J.,Lu F.,Lilley C.E.,Spanos S.,Malley T.,Gibbs R.A.
A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13.
Genome Res.
6
314-326
1996
876498
Ansari-Lari M.A.,Shen Y.,Muzny D.M.,Lee W.,Gibbs R.A.
Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination.
Genome Res.
7
268-280
1997
876499
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
876500
Scherer S.E.,Muzny D.M.,Buhay C.J.,Chen R.,Cree A.,Ding Y.,Dugan-Rocha S.,Gill R.,Gunaratne P.,Harris R.A.,Hawes A.C.,Hernandez J.,Hodgson A.V.,Hume J.,Jackson A.,Khan Z.M.,Kovar-Smith C.,Lewis L.R.,Lozado R.J.,Metzker M.L.,Milosavljevic A.,Miner G.R.,Montgomery K.T.,Morgan M.B.,Nazareth L.V.,Scott G.,Sodergren E.,Song X.-Z.,Steffen D.,Lovering R.C.,Wheeler D.A.,Worley K.C.,Yuan Y.,Zhang Z.,Adams C.Q.,Ansari-Lari M.A.,Ayele M.,Brown M.J.,Chen G.,Chen Z.,Clerc-Blankenburg K.P.,Davis C.,Delgado O.,Dinh H.H.,Draper H.,Gonzalez-Garay M.L.,Havlak P.,Jackson L.R.,Jacob L.S.,Kelly S.H.,Li L.,Li Z.,Liu J.,Liu W.,Lu J.,Maheshwari M.,Nguyen B.-V.,Okwuonu G.O.,Pasternak S.,Perez L.M.,Plopper F.J.H.,Santibanez J.,Shen H.,Tabor P.E.,Verduzco D.,Waldron L.,Wang Q.,Williams G.A.,Zhang J.,Zhou J.,Allen C.C.,Amin A.G.,Anyalebechi V.,Bailey M.,Barbaria J.A.,Bimage K.E.,Bryant N.P.,Burch P.E.,Burkett C.E.,Burrell K.L.,Calderon E.,Cardenas V.,Carter K.,Casias K.,Cavazos I.,Cavazos S.R.,Ceasar H.,Chacko J.,Chan S.N.,Chavez D.,Christopoulos C.,Chu J.,Cockrell R.,Cox C.D.,Dang M.,Dathorne S.R.,David R.,Davis C.M.,Davy-Carroll L.,Deshazo D.R.,Donlin J.E.,D'Souza L.,Eaves K.A.,Egan A.,Emery-Cohen A.J.,Escotto M.,Flagg N.,Forbes L.D.,Gabisi A.M.,Garza M.,Hamilton C.,Henderson N.,Hernandez O.,Hines S.,Hogues M.E.,Huang M.,Idlebird D.G.,Johnson R.,Jolivet A.,Jones S.,Kagan R.,King L.M.,Leal B.,Lebow H.,Lee S.,LeVan J.M.,Lewis L.C.,London P.,Lorensuhewa L.M.,Loulseged H.,Lovett D.A.,Lucier A.,Lucier R.L.,Ma J.,Madu R.C.,Mapua P.,Martindale A.D.,Martinez E.,Massey E.,Mawhiney S.,Meador M.G.,Mendez S.,Mercado C.,Mercado I.C.,Merritt C.E.,Miner Z.L.,Minja E.,Mitchell T.,Mohabbat F.,Mohabbat K.,Montgomery B.,Moore N.,Morris S.,Munidasa M.,Ngo R.N.,Nguyen N.B.,Nickerson E.,Nwaokelemeh O.O.,Nwokenkwo S.,Obregon M.,Oguh M.,Oragunye N.,Oviedo R.J.,Parish B.J.,Parker D.N.,Parrish J.,Parks K.L.,Paul H.A.,Payton B.A.,Perez A.,Perrin W.,Pickens A.,Primus E.L.,Pu L.-L.,Puazo M.,Quiles M.M.,Quiroz J.B.,Rabata D.,Reeves K.,Ruiz S.J.,Shao H.,Sisson I.,Sonaike T.,Sorelle R.P.,Sutton A.E.,Svatek A.F.,Svetz L.A.,Tamerisa K.S.,Taylor T.R.,Teague B.,Thomas N.,Thorn R.D.,Trejos Z.Y.,Trevino B.K.,Ukegbu O.N.,Urban J.B.,Vasquez L.I.,Vera V.A.,Villasana D.M.,Wang L.,Ward-Moore S.,Warren J.T.,Wei X.,White F.,Williamson A.L.,Wleczyk R.,Wooden H.S.,Wooden S.H.,Yen J.,Yoon L.,Yoon V.,Zorrilla S.E.,Nelson D.,Kucherlapati R.,Weinstock G.,Gibbs R.A.
The finished DNA sequence of human chromosome 12.
Nature
440
346-351
2006
876502
Boyer T.G.,Krug J.R.,Maquat L.E.
Transcriptional regulatory sequences of the housekeeping gene for human triosephosphate isomerase.
J. Biol. Chem.
264
5177-5187
1989
876503
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
876505
Lu H.S.,Yuan P.M.,Gracy R.W.
Primary structure of human triosephosphate isomerase.
J. Biol. Chem.
259
11958-11968
1984
876506
Rasmussen R.K.,Ji H.,Eddes J.S.,Moritz R.L.,Reid G.E.,Simpson R.J.,Dorow D.S.
Two-dimensional electrophoretic analysis of human breast carcinoma proteins: mapping of proteins that bind to the SH3 domain of mixed lineage kinase MLK2.
Electrophoresis
18
588-598
1997
876507
Ji H.,Reid G.E.,Moritz R.L.,Eddes J.S.,Burgess A.W.,Simpson R.J.
A two-dimensional gel database of human colon carcinoma proteins.
Electrophoresis
18
605-613
1997
876509
Olsen J.V.,Blagoev B.,Gnad F.,Macek B.,Kumar C.,Mortensen P.,Mann M.
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Cell
127
635-648
2006
876510
Beranova-Giorgianni S.,Zhao Y.,Desiderio D.M.,Giorgianni F.
Phosphoproteomic analysis of the human pituitary.
Pituitary
9
109-120
2006
876511
Yu L.R.,Zhu Z.,Chan K.C.,Issaq H.J.,Dimitrov D.S.,Veenstra T.D.
Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.
J. Proteome Res.
6
4150-4162
2007
876512
Tang L.-Y.,Deng N.,Wang L.-S.,Dai J.,Wang Z.-L.,Jiang X.-S.,Li S.-J.,Li L.,Sheng Q.-H.,Wu D.-Q.,Li L.,Zeng R.
Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction.
Mol. Cell. Proteomics
6
1952-1967
2007
876513
Carrascal M.,Ovelleiro D.,Casas V.,Gay M.,Abian J.
Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.
J. Proteome Res.
7
5167-5176
2008
876514
Dephoure N.,Zhou C.,Villen J.,Beausoleil S.A.,Bakalarski C.E.,Elledge S.J.,Gygi S.P.
A quantitative atlas of mitotic phosphorylation.
Proc. Natl. Acad. Sci. U.S.A.
105
10762-10767
2008
876515
Gauci S.,Helbig A.O.,Slijper M.,Krijgsveld J.,Heck A.J.,Mohammed S.
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Anal. Chem.
81
4493-4501
2009
876516
Mayya V.,Lundgren D.H.,Hwang S.-I.,Rezaul K.,Wu L.,Eng J.K.,Rodionov V.,Han D.K.
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Sci. Signal.
2
0-0
2009
876517
Choudhary C.,Kumar C.,Gnad F.,Nielsen M.L.,Rehman M.,Walther T.C.,Olsen J.V.,Mann M.
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Science
325
834-840
2009
876518
Olsen J.V.,Vermeulen M.,Santamaria A.,Kumar C.,Miller M.L.,Jensen L.J.,Gnad F.,Cox J.,Jensen T.S.,Nigg E.A.,Brunak S.,Mann M.
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
Sci. Signal.
3
0-0
2010
876519
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
876520
Rigbolt K.T.,Prokhorova T.A.,Akimov V.,Henningsen J.,Johansen P.T.,Kratchmarova I.,Kassem M.,Mann M.,Olsen J.V.,Blagoev B.
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
Sci. Signal.
4
0-0
2011
876521
Rosenow A.,Noben J.P.,Jocken J.,Kallendrusch S.,Fischer-Posovszky P.,Mariman E.C.,Renes J.
Resveratrol-induced changes of the human adipocyte secretion profile.
J. Proteome Res.
11
4733-4743
2012
876522
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
J. Proteome Res.
12
260-271
2013
876523
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
876524
Guo A.,Gu H.,Zhou J.,Mulhern D.,Wang Y.,Lee K.A.,Yang V.,Aguiar M.,Kornhauser J.,Jia X.,Ren J.,Beausoleil S.A.,Silva J.C.,Vemulapalli V.,Bedford M.T.,Comb M.J.
Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
Mol. Cell. Proteomics
13
372-387
2014
876525
Impens F.,Radoshevich L.,Cossart P.,Ribet D.
Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.
Proc. Natl. Acad. Sci. U.S.A.
111
12432-12437
2014
876526
Vaca Jacome A.S.,Rabilloud T.,Schaeffer-Reiss C.,Rompais M.,Ayoub D.,Lane L.,Bairoch A.,Van Dorsselaer A.,Carapito C.
N-terminome analysis of the human mitochondrial proteome.
Proteomics
15
2519-2524
2015
876527
Mande S.C.,Mainfroid V.,Kalk K.H.,Goraj K.,Martial J.A.,Hol W.G.J.
Crystal structure of recombinant human triosephosphate isomerase at 2.8-A resolution. Triosephosphate isomerase-related human genetic disorders and comparison with the trypanosomal enzyme.
Protein Sci.
3
810-821
1994
876528
Kinoshita T.,Maruki R.,Warizaya M.,Nakajima H.,Nishimura S.
Structure of a high-resolution crystal form of human triosephosphate isomerase: improvement of crystals using the gel-tube method.
Acta Crystallogr. F
61
346-349
2005
876529
Rodriguez-Almazan C.,Arreola R.,Rodriguez-Larrea D.,Aguirre-Lopez B.,de Gomez-Puyou M.T.,Perez-Montfort R.,Costas M.,Gomez-Puyou A.,Torres-Larios A.
Structural basis of human triosephosphate isomerase deficiency: mutation E104D is related to alterations of a conserved water network at the dimer interface.
J. Biol. Chem.
283
23254-23263
2008
876530
Daar I.O.,Artymiuk P.J.,Phillips D.C.,Maquat L.E.
Human triose-phosphate isomerase deficiency: a single amino acid substitution results in a thermolabile enzyme.
Proc. Natl. Acad. Sci. U.S.A.
83
7903-7907
1986
876532
Perry B.A.,Mohrenweiser H.W.
Human triosephosphate isomerase: substitution of Arg for Gly at position 122 in a thermolabile electromorph variant, TPI-Manchester.
Hum. Genet.
88
634-638
1992
876533
Chang M.-L.,Artymiuk P.J.,Wu X.,Hollan S.,Lammi A.,Maquat L.E.
Human triosephosphate isomerase deficiency resulting from mutation of Phe-240.
Am. J. Hum. Genet.
52
1260-1269
1993
876534
Watanabe M.,Zingg B.C.,Mohrenweiser H.W.
Molecular analysis of a series of alleles in humans with reduced activity at the triosephosphate isomerase locus.
Am. J. Hum. Genet.
58
308-316
1996
876535
Arya R.,Lalloz M.R.A.,Bellingham A.J.,Layton D.M.
Evidence for founder effect of the Glu104Asp substitution and identification of new mutations in triosephosphate isomerase deficiency.
Hum. Mutat.
10
290-294
1997
