Sequence of MCAS_MYCBO
EC Number:2.3.1.111
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
mycocerosate synthase
Q02251
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
2111
224396
Reaction
a long-chain acyl-[mycocerosic acid synthase] + 3 methylmalonyl-CoA + 6 NADPH + 6 H+ = a trimethylated-mycocerosoyl-[mycocerosate synthase] + 3 CoA + 3 CO2 + 6 NADP+ + 3 H2O
Other sequences found for EC No. 2.3.1.111
General information:
Sequence
0 MESRVTPVAV IGMGCRLPGG INSPDKLWES LLRGDDLVTE IPPDRWDADD YYDPEPGVPG
60 RSVSRWGGFL DDVAGFDAEF FGISEREATS IDPQQRLLLE TSWEAIEHAG LDPASLAGSS
120 TAVFTGLTHE DYLVLTTTAG GLASPYVVTG LNNSVASGRI AHTLGLHGPA MTFDTACSSG
180 LMAVHLACRS LHDGEADLAL AGGCAVLLEP HACVAASAQG MLSSTGRCHS FDADADGFVR
240 SEGCAMVLLK RLPDALRDGN RIFAVVRGTA TNQDGRTETL TMPSEDAQVA VYRAALAAAG
300 VQPETVGVVE AHGTGTPIGD PIEYRSLARV YGAGTPCALG SAKSNMGHST ASAGTVGLIK
360 AILSLRHGVV PPLLHFNRLP DELSDVETGL FVPQAVTPWP NGNDHTPKRV AVSSFGMSGT
420 NVHAIVEEAP AEASAPESSP GDAEVGPRLF MLSSTSSDAL RQTARQLATW VEEHQDCVAA
480 SDLAYTLARG RAHRPVRTAV VAANLPELVE GLREVADGDA LYDAAVGHGD RGPVWVFSGQ
540 GSQWAAMGTQ LLASEPVFAA TIAKLEPVIA AESGFSVTEA ITAQQTVTGI DKVQPAVFAV
600 QVALAATMEQ TYGVRPGAVV GHSMGESAAA VVAGALSLED AARVICRRSK LMTRIAGAGA
660 MGSVELPAKQ VNSELMARGI DDVVVSVVAS PQSTVIGGTS DTVRDLIARW EQRDVMAREV
720 AVDVASHSPQ VDPILDDLAA ALADIAPMTP KVPYYSATLF DPREQPVCDG AYWVDNLRNT
780 VQFAAAVQAA MEDGYRVFAE LSPHPLLTHA VEQTGRSLDM SVAALAGMRR EQPLPHGLRG
840 LLTELHRAGA ALDYSALYPA GRLVDAPLPA WTHARLFIDD DGQEQRAQGA CTITVHPLLG
900 SHVRLTEEPE RHVWQGDVGT SVLSWLSDHQ VHNVAALPGA AYCEMALAAA AEVFGEAAEV
960 RDITFEQMLL LDEQTPIDAV ASIDAPGVVN FTVETNRDGE TTRHATAALR AAEDDCPPPG
1020 YDITALLQAH PHAVNGTAMR ESFAERGVTL GAAFGGLTTA HTAEAGAATV LAEVALPASI
1080 RFQQGAYRIH PALLDACFQS VGAGVQAGTA TGGLLLPLGV RSLRAYGPTR NARYCYTRLT
1140 KAFNDGTRGG EADLDVLDEH GTVLLAVRGL RMGTGTSERD ERDRLVSERL LTLGWQQRAL
1200 PEVGDGEAGS WLLIDTSNAV DTPDMLASTL TDALKSHGPQ GTECASLSWS VQDTPPNDQA
1260 GLEKLGSQLR GRDGVVIVYG PRVGDPDEHS LLAGREQVRH LVRITRELAE FEGELPRLFV
1320 VTRQAQIVKP HDSGERANLE QAGLRGLLRV ISSEHPMLRT TLIDVDEHTD VERVAQQLLS
1380 GSEEDETAWR NGDWYVARLT PSPLGHEERR TAVLDPDHDG MRVQVRRPGD LQTLEFVASD
1440 RVPPGPGQIE VAVSMSSINF ADVLIAFGRF PIIDDREPQL GMDFVGVVTA VGEGVTGHQV
1500 GDRVGGFSEG GCWRTFLTCD ANLAVTLPPG LTDEQAITAA TAHATAWYGL NDLAQIKAGD
1560 KVLIHSATGG VGQAAISIAR AKGAEIFATA GNPAKRAMLR DMGVEHVYDS RSVEFAEQIR
1620 RDTDGYGVDI VLNSLTGAAQ RAGLELLAFG GRFVEIGKAD VYGNTRLGLF PFRRGLTFYY
1680 LDLALMSVTQ PDRVRELLAT VFKLTADGVL TAPQCTHYPL AEAADAIRAM SNAEHTGKLV
1740 LDVPRSGRRS VAVTPEQAPL YRRDGSYIIT GGLGGLGLFF ASKLAAAGCG RIVLTARSQP
1800 NPKARQTIEG LRAAGADIVV ECGNIAEPDT ADRLVSAATA TGLPLRGVLH SAAVVEDATL
1860 TNITDELIDR DWSPKVFGSW NLHRATLGQP LDWFCLFSSG AALLGSPGQG AYAAANSWVD
1920 VFAHWRRAQG LPVSAIAWGA WGEVGRATFL AEGGEIMITP EEGAYAFETL VRHDRAYSGY
1980 IPILGAPWLA DLVRRSPWGE MFASTGQRSR GPSKFRMELL SLPQDEWAGR LRRLLVEQAS
2040 VILRRTIDAD RSFIEYGLDS LGMLEMRTHV ETETGIRLTP KVIATNNTAR ALAQYLADTL
2100 AEEQAAAPAA S
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
822823
Mathur M.,Kolattukudy P.E.
Molecular cloning and sequencing of the gene for mycocerosic acid synthase, a novel fatty acid elongating multifunctional enzyme, from Mycobacterium tuberculosis var. bovis Bacillus Calmette-Guerin.
J. Biol. Chem.
267
19388-19395
1992
822824
Garnier T.,Eiglmeier K.,Camus J.-C.,Medina N.,Mansoor H.,Pryor M.,Duthoy S.,Grondin S.,Lacroix C.,Monsempe C.,Simon S.,Harris B.,Atkin R.,Doggett J.,Mayes R.,Keating L.,Wheeler P.R.,Parkhill J.,Barrell B.G.,Cole S.T.,Gordon S.V.,Hewinson R.G.
The complete genome sequence of Mycobacterium bovis.
Proc. Natl. Acad. Sci. U.S.A.
100
7877-7882
2003
822825
Malone K.M.,Farrell D.,Stuber T.P.,Schubert O.T.,Aebersold R.,Robbe-Austerman S.,Gordon S.V.
Updated reference genome sequence and annotation of Mycobacterium bovis AF2122/97.
Genome Announc.
5
0-0
2017
822826
Rainwater D.L.,Kolattukudy P.E.
Fatty acid biosynthesis in Mycobacterium tuberculosis var. bovis Bacillus Calmette-Guerin. Purification and characterization of a novel fatty acid synthase, mycocerosic acid synthase, which elongates n-fatty acyl-CoA with methylmalonyl-CoA.
J. Biol. Chem.
260
616-623
1985
