Sequence of LOVC_ASPTN

lovastatin nonaketide synthase

Q0C8M1

363

39442

820129

Alberts A.W.,Chen J.,Kuron G.,Hunt V.,Huff J.,Hoffman C.,Rothrock J.,Lopez M.,Joshua H.,Harris E.,Patchett A.,Monaghan R.,Currie S.,Stapley E.,Albers-Schonberg G.,Hensens O.,Hirshfield J.,Hoogsteen K.,Liesch J.,Springer J.

Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.

Proc. Natl. Acad. Sci. U.S.A.

77

3957-3961

1980

820130

Kennedy J.,Auclair K.,Kendrew S.G.,Park C.,Vederas J.C.,Hutchinson C.R.

Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis.

Science

284

1368-1372

1999

820131

Hendrickson L.,Davis C.R.,Roach C.,Nguyen D.K.,Aldrich T.,McAda P.C.,Reeves C.D.

Lovastatin biosynthesis in Aspergillus terreus: characterization of blocked mutants, enzyme activities and a multifunctional polyketide synthase gene.

Chem. Biol.

6

429-439

1999

820132

Sorensen J.L.,Auclair K.,Kennedy J.,Hutchinson C.R.,Vederas J.C.

Transformations of cyclic nonaketides by Aspergillus terreus mutants blocked for lovastatin biosynthesis at the lovA and lovC genes.

Org. Biomol. Chem.

1

50-59

2003

820133

Xie X.,Watanabe K.,Wojcicki W.A.,Wang C.C.,Tang Y.

Biosynthesis of lovastatin analogs with a broadly specific acyltransferase.

Chem. Biol.

13

1161-1169

2006

820134

Xie X.,Pashkov I.,Gao X.,Guerrero J.L.,Yeates T.O.,Tang Y.

Rational improvement of simvastatin synthase solubility in Escherichia coli leads to higher whole-cell biocatalytic activity.

Biotechnol. Bioeng.

102

20-28

2009

820135

Gao X.,Xie X.,Pashkov I.,Sawaya M.R.,Laidman J.,Zhang W.,Cacho R.,Yeates T.O.,Tang Y.

Directed evolution and structural characterization of a simvastatin synthase.

Chem. Biol.

16

1064-1074

2009

820136

Xie X.,Meehan M.J.,Xu W.,Dorrestein P.C.,Tang Y.

Acyltransferase mediated polyketide release from a fungal megasynthase.

J. Am. Chem. Soc.

131

8388-8389

2009

820137

Ma S.M.,Li J.W.,Choi J.W.,Zhou H.,Lee K.K.,Moorthie V.A.,Xie X.,Kealey J.T.,Da Silva N.A.,Vederas J.C.,Tang Y.

Complete reconstitution of a highly reducing iterative polyketide synthase.

Science

326

589-592

2009

820138

Meehan M.J.,Xie X.,Zhao X.,Xu W.,Tang Y.,Dorrestein P.C.

FT-ICR-MS characterization of intermediates in the biosynthesis of the alpha-methylbutyrate side chain of lovastatin by the 277 kDa polyketide synthase LovF.

Biochemistry

50

287-299

2011

820139

Barriuso J.,Nguyen D.T.,Li J.W.,Roberts J.N.,MacNevin G.,Chaytor J.L.,Marcus S.L.,Vederas J.C.,Ro D.K.

Double oxidation of the cyclic nonaketide dihydromonacolin L to monacolin J by a single cytochrome P450 monooxygenase, LovA.

J. Am. Chem. Soc.

133

8078-8081

2011

820140

Ames B.D.,Nguyen C.,Bruegger J.,Smith P.,Xu W.,Ma S.,Wong E.,Wong S.,Xie X.,Li J.W.,Vederas J.C.,Tang Y.,Tsai S.C.

Crystal structure and biochemical studies of the trans-acting polyketide enoyl reductase LovC from lovastatin biosynthesis.

Proc. Natl. Acad. Sci. U.S.A.

109

11144-11149

2012

820141

Xu W.,Chooi Y.H.,Choi J.W.,Li S.,Vederas J.C.,Da Silva N.A.,Tang Y.

LovG: the thioesterase required for dihydromonacolin L release and lovastatin nonaketide synthase turnover in lovastatin biosynthesis.

Angew. Chem. Int. Ed. Engl.

52

6472-6475

2013

820142

Jimenez-Oses G.,Osuna S.,Gao X.,Sawaya M.R.,Gilson L.,Collier S.J.,Huisman G.W.,Yeates T.O.,Tang Y.,Houk K.N.

The role of distant mutations and allosteric regulation on LovD active site dynamics.

Nat. Chem. Biol.

10

431-436

2014

820143

Chen M.C.,Tsai Y.C.,Tseng J.H.,Liou J.J.,Horng S.,Wen H.C.,Fan Y.C.,Zhong W.B.,Hsu S.P.

Simvastatin inhibits cell proliferation and migration in human anaplastic thyroid cancer.

Int. J. Mol. Sci.

18

0-0

2017

820144

Zhong W.B.,Tsai Y.C.,Chin L.H.,Tseng J.H.,Tang L.W.,Horng S.,Fan Y.C.,Hsu S.P.

A synergistic anti-cancer effect of troglitazone and lovastatin in a human anaplastic thyroid cancer cell line and in a mouse xenograft model.

Int. J. Mol. Sci.

19

0-0

2018