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Sequence of IVD_HUMAN

EC Number:1.3.8.1

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
short-chain acyl-CoA dehydrogenase
P26440
Homo sapiens
426
46651
Reaction
a short-chain acyl-CoA + electron-transfer flavoprotein = a short-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein
Other sequences found for EC No. 1.3.8.1

General information:

Sequence
show sequence in fasta format
  0 MAEMATATRL LGWRVASWRL RPPLAGFVSQ RAHSLLPVDD AINGLSEEQR QLRQTMAKFL
 60 QEHLAPKAQE IDRSNEFKNL REFWKQLGNL GVLGITAPVQ YGGSGLGYLE HVLVMEEISR
120 ASGAVGLSYG AHSNLCINQL VRNGNEAQKE KYLPKLISGE YIGALAMSEP NAGSDVVSMK
180 LKAEKKGNHY ILNGNKFWIT NGPDADVLIV YAKTDLAAVP ASRGITAFIV EKGMPGFSTS
240 KKLDKLGMRG SNTCELIFED CKIPAANILG HENKGVYVLM SGLDLERLVL AGGPLGLMQA
300 VLDHTIPYLH VREAFGQKIG HFQLMQGKMA DMYTRLMACR QYVYNVAKAC DEGHCTAKDC
360 AGVILYSAEC ATQVALDGIQ CFGGNGYIND FPMGRFLRDA KLYEIGAGTS EVRRLVIGRA
420 FNADFH
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
814659
Matsubara Y.,Ito M.,Glassberg R.,Satyabhama S.,Ikeda Y.,Tanaka K.
Nucleotide sequence of messenger RNA encoding human isovaleryl-coenzyme A dehydrogenase and its expression in isovaleric acidemia fibroblasts.
J. Clin. Invest.
85
1058-1064
1990
814660
Vockley J.,Rogan P.K.,Anderson B.D.,Willard J.,Seelan R.S.,Smith D.I.,Liu W.
Exon skipping in IVD RNA processing in isovaleric acidemia caused by point mutations in the coding region of the IVD gene.
Am. J. Hum. Genet.
66
356-367
2000
814661
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
814662
Zody M.C.,Garber M.,Sharpe T.,Young S.K.,Rowen L.,O'Neill K.,Whittaker C.A.,Kamal M.,Chang J.L.,Cuomo C.A.,Dewar K.,FitzGerald M.G.,Kodira C.D.,Madan A.,Qin S.,Yang X.,Abbasi N.,Abouelleil A.,Arachchi H.M.,Baradarani L.,Birditt B.,Bloom S.,Bloom T.,Borowsky M.L.,Burke J.,Butler J.,Cook A.,DeArellano K.,DeCaprio D.,Dorris L. III,Dors M.,Eichler E.E.,Engels R.,Fahey J.,Fleetwood P.,Friedman C.,Gearin G.,Hall J.L.,Hensley G.,Johnson E.,Jones C.,Kamat A.,Kaur A.,Locke D.P.,Madan A.,Munson G.,Jaffe D.B.,Lui A.,Macdonald P.,Mauceli E.,Naylor J.W.,Nesbitt R.,Nicol R.,O'Leary S.B.,Ratcliffe A.,Rounsley S.,She X.,Sneddon K.M.B.,Stewart S.,Sougnez C.,Stone S.M.,Topham K.,Vincent D.,Wang S.,Zimmer A.R.,Birren B.W.,Hood L.,Lander E.S.,Nusbaum C.
Analysis of the DNA sequence and duplication history of human chromosome 15.
Nature
440
671-675
2006
814664
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
814666
Parimoo B.,Tanaka K.
Structural organization of the human isovaleryl-CoA dehydrogenase gene.
Genomics
15
582-590
1993
814667
Vockley J.,Nagao M.,Parimoo B.,Tanaka K.
The variant human isovaleryl-CoA dehydrogenase gene responsible for type II isovaleric acidemia determines an RNA splicing error, leading to the deletion of the entire second coding exon and the production of a truncated precursor protein that interacts poorly with mitochondrial import receptors.
J. Biol. Chem.
267
2494-2501
1992
814668
Gevaert K.,Goethals M.,Martens L.,Van Damme J.,Staes A.,Thomas G.R.,Vandekerckhove J.
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
Nat. Biotechnol.
21
566-569
2003
814669
Mohsen A.W.,Vockley J.
Identification of the active site catalytic residue in human isovaleryl-CoA dehydrogenase.
Biochemistry
34
10146-10152
1995
814670
Choudhary C.,Kumar C.,Gnad F.,Nielsen M.L.,Rehman M.,Walther T.C.,Olsen J.V.,Mann M.
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Science
325
834-840
2009
814671
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
814672
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
814673
Vaca Jacome A.S.,Rabilloud T.,Schaeffer-Reiss C.,Rompais M.,Ayoub D.,Lane L.,Bairoch A.,Van Dorsselaer A.,Carapito C.
N-terminome analysis of the human mitochondrial proteome.
Proteomics
15
2519-2524
2015
814674
Tiffany K.A.,Roberts D.L.,Wang M.,Paschke R.,Mohsen A.W.,Vockley J.,Kim J.-J.P.
Structure of human isovaleryl-CoA dehydrogenase at 2.6-A resolution: structural basis for substrate specificity.
Biochemistry
36
8455-8464
1997
814675
Vockley J.,Parimoo B.,Tanaka K.
Molecular characterization of four different classes of mutations in the isovaleryl-CoA dehydrogenase gene responsible for isovaleric acidemia.
Am. J. Hum. Genet.
49
147-157
1991
814676
Mohsen A.-W.A.,Anderson B.D.,Volchenboum S.L.,Battaile K.P.,Tiffany K.A.,Roberts D.L.,Kim J.-J.P.,Vockley J.
Characterization of molecular defects in isovaleryl-CoA dehydrogenase in patients with isovaleric acidemia.
Biochemistry
37
10325-10335
1998
814677
Vatanavicharn N.,Liammongkolkul S.,Sakamoto O.,Sathienkijkanchai A.,Wasant P.
Phenotypic and mutation spectrums of Thai patients with isovaleric acidemia.
Pediatr. Int.
53
990-994
2011
814678
Dercksen M.,Duran M.,Ijlst L.,Mienie L.J.,Reinecke C.J.,Ruiter J.P.,Waterham H.R.,Wanders R.J.
Clinical variability of isovaleric acidemia in a genetically homogeneous population.
J. Inherit. Metab. Dis.
35
1021-1029
2012
814679
Bei F.,Sun J.H.,Yu Y.G.,Jia J.,Zheng Z.J.,Fu Q.H.,Cai W.
Two novel isovaleryl-CoA dehydrogenase gene mutations in a Chinese infant.
Gene
524
396-400
2013
814680
Zaki O.K.,Priya Doss C.G.,Ali S.A.,Murad G.G.,Elashi S.A.,Ebnou M.S.A.,Kumar D T.,Khalifa O.,Gamal R.,El Abd H.S.A.,Nasr B.N.,Zayed H.
Genotype-phenotype correlation in patients with isovaleric acidaemia: comparative structural modelling and computational analysis of novel variants.
Hum. Mol. Genet.
26
3105-3115
2017