Sequence of HN_NDVB1
EC Number:3.2.1.18
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
exo-alpha-sialidase
Q91UL0
Newcastle disease virus (strain Chicken/United States/B1/48)
577
63227
Reaction
colominic acid + H2O = sialic acid + lactose
Other sequences found for EC No. 3.2.1.18
General information:
Sequence
0 MDRAVSQVAL ENDEREAKNT WRLIFRIAIL FLTVVTLAIS VASLLYSMGA STPSDLVGIP
60 TRISRAEEKI TSTLGSNQDV VDRIYKQVAL ESPLALLNTE TTIMNAITSL SYQINGAANN
120 SGWGAPIHDP DYIGGIGKEL IVDDASDVTS FYPSAFQEHL NFIPAPTTGS GCTRIPSFDM
180 SATHYCYTHN VILSGCRDHS HSYQYLALGV LRTSATGRVF FSTLRSINLD DTQNRKSCSV
240 SATPLGCDML CSKATETEEE DYNSAVPTRM VHGRLGFDGQ YHEKDLDVTT LFGDWVANYP
300 GVGGGSFIDS RVWFSVYGGL KPNSPSDTVQ EGKYVIYKRY NDTCPDEQDY QIRMAKSSYK
360 PGRFGGKRIQ QAILSIKVST SLGEDPVLTV PPNTVTLMGA EGRILTVGTS HFLYQRGSSY
420 FSPALLYPMT VSNKTATLHS PYTFNAFTRP GSIPCQASAR CPNSCVTGVY TDPYPLIFYR
480 NHTLRGVFGT MLDGEQARLN PASAVFDSTS RSRITRVSSS SIKAAYTTST CFKVVKTNKT
540 YCLSIAEISN TLFGEFRIVP LLVEILKDDG VREARSG
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
809656
McGinnes L.W.,Gravel K.,Morrison T.G.
Newcastle disease virus HN protein alters the conformation of the F protein at cell surfaces.
J. Virol.
76
12622-12633
2002
809657
Takimoto T.,Taylor G.L.,Connaris H.C.,Crennell S.J.,Portner A.
Role of the hemagglutinin-neuraminidase protein in the mechanism of paramyxovirus-cell membrane fusion.
J. Virol.
76
13028-13033
2002
809658
Gravel K.A.,Morrison T.G.
Interacting domains of the HN and F proteins of newcastle disease virus.
J. Virol.
77
11040-11049
2003
809659
Zaitsev V.,von Itzstein M.,Groves D.,Kiefel M.,Takimoto T.,Portner A.,Taylor G.
Second sialic acid binding site in Newcastle disease virus hemagglutinin-neuraminidase: implications for fusion.
J. Virol.
78
3733-3741
2004
809660
Khattar S.K.,Yan Y.,Panda A.,Collins P.L.,Samal S.K.
A Y526Q mutation in the Newcastle disease virus HN protein reduces its functional activities and attenuates virus replication and pathogenicity.
J. Virol.
83
7779-7782
2009
809661
Mirza A.M.,Iorio R.M.
A mutation in the stalk of the newcastle disease virus hemagglutinin-neuraminidase (HN) protein prevents triggering of the F protein despite allowing efficient HN-F complex formation.
J. Virol.
87
8813-8815
2013
809662
Pegg C.L.,Hoogland C.,Gorman J.J.
Site-specific glycosylation of the Newcastle disease virus haemagglutinin-neuraminidase.
Glycoconj. J.
34
181-197
2017
809663
Sun J.,Han Z.,Qi T.,Zhao R.,Liu S.
Chicken galectin-1B inhibits Newcastle disease virus adsorption and replication through binding to hemagglutinin-neuraminidase (HN) glycoprotein.
J. Biol. Chem.
292
20141-20161
2017
